Immuno-Grade FFA2 Antibodies
FFA2 is predominantly expressed in adipose, inflammatory cells and the GI-tract. Elevation of FFA2 expression was observed in adipose of mice fed a high-fat diet compared that of mice on a low-fat diet suggesting a role in adipogenesis. FFA2 may be involved in the regulation of GI gastrointestinal motility and secretion since the receptor co-localizes with PYY in mucosal epithelium and mast cells. Expression of FFA2 has also been described in mouse pancreas with increased expression in islets from db/db and ob/ob mice. FFA2 is mainly coupled to Gαq. Acetate and propionate are the most potent ligands for the receptor with pentanoate less active.