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Vasopressin/Oxytocin Receptor Antibodies

Vasopressin and oxytocin receptors are activated by the endogenous cyclic nonapeptides vasopressin (AVP) and oxytocin (OT). These peptides are derived from precursors which also produce neurophysins. Vasopressin and oxytocin differ at only 2 amino acids (positions 3 and 8). Four receptors exist in mammals, three for AVP and a unique receptor for OT, although AVP possesses a nanomolar affinity for all subtypes. AVP is also named the antidiuretic hormone (ADH) due to its effect on the regulation of water body balance whereas oxytocin is defined as the "quick birth" hormone because of its highly potent uterotonic activity. AVP has multiple physiological functions, including body water regulation, control of blood pressure, platelet aggregation, release of coagulation factors, cell proliferation, and effects on body temperature, insulin release, corticotropin release, memory and social behaviour. All these actions are mediated through activation of three specific membrane-bound receptors present at the surface of the target cells. On the basis of pharmacological and functional studies, these receptors have been classified as V1A, V1B and V2 subtypes. The neurohypophysial peptide oxytocin facilitates reproduction in all vertebrates at several levels via activation of the OT receptor.

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pS373/pS374-V1B (phospho-Vasopressin Receptor 1B Antibody)
pS373/pS374-V1B (phospho-Vasopressin Receptor...
Serine373/Serine374 (S373/S374) is major phosphorylation site of the Vasopressin Receptor 1B (V1B). The pS373/pS374-V1B antibody detects phosphorylation in response to agonists. S373/S374 phosphorylation is likely to be involved in...
$ 350.00
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Agonist-induced Threonine377/Threonine378 phosphorylation of the Vasopressin Receptor 1B
pT377/pT378-V1B (phospho-Vasopressin Receptor...
Threonine377/Threonine378 (T377/T378) is major phosphorylation site of the Vasopressin Receptor 1B (V1B). The pT377/pT378-V1B antibody detects phosphorylation in response to agonists. T377/T378 phosphorylation is likely to be involved in...
$ 350.00
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Agonist-induced Serine397/Threonine398 phosphorylation of the Vasopressin Receptor 1A
pS397/pT398-V1A (phospho-Vasopressin Receptor...
Serine397/Threonine398 (S397/T398) is major phosphorylation site of the Vasopressin Receptor 1A (V1A). The pS397/pT398-V1A antibody detects phosphorylation in response to agonists. S397/T398 phosphorylation is likely to be involved in...
$ 350.00
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Agonist-induced Threonine386/Serine389 phosphorylation of the Vasopressin Receptor 1A
pT386/pS389-V1A (phospho-Vasopressin Receptor...
Threonine386/Serine389 (T368/S389) is major phosphorylation site of the Vasopressin Receptor 1A (V1A). The pT386/pS389-V1A antibody detects phosphorylation in response to agonists. T386/S389 phosphorylation is likely to be involved in...
$ 350.00
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Agonist-induced Threonine378/Serine380 phosphorylation of the Vasopressin Receptor 1A
pT378/pS380-V1A (phospho-Vasopressin Receptor...
Threonine378/Serine380 (T378/S380) is major phosphorylation site of the Vasopressin Receptor 1A (V1A). The pT378/pS380-V1A antibody detects phosphorylation in response to agonists. T378/S380 phosphorylation is likely to be involved in...
$ 350.00
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Agonist-induced Serine350 phosphorylation of the Vasopressin Receptor 2
pS350-V2 (phospho-Vasopressin Receptor 2 Antibody)
Serine350 (S350) is major phosphorylation site of the Vasopresssin Receptor 2 (V2). The pS350-V2 antibody detects phosphorylation in response to agonists. S350 phosphorylation is likely to be involved in efficient ligand sequestration by...
$ 350.00
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Agonist-induced Threonine359/Threonine360 phosphorylation of the Vasopressin Receptor 2.
pT359/pT360-V2 (phospho-Vasopressin Receptor 2...
Threonine359/Threonine360 (T359/T360) is major phosphorylation site of the Vasopressin Receptor 2 (V2). The pT359/pT360-V2 antibody detects phosphorylation in response to agonists. T359/T360 phosphorylation is likely to be involved in...
$ 350.00
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Agonist-induced Serine362/Serine363/Serine364 phosphorylation of the Vasopressin Receptor 2
pS362/pS363/pS364-V2 (phospho-Vasopressin...
Serine362/Serine363/Serine364 (S362/S363/S364) is major phosphorylation site of the Vasopresssin Receptor 2 (V2). The pS362/pS363/pS364-V2 antibody detects phosphorylation in response to agonists. S362/S363/S364 phosphorylation is likely...
$ 350.00

For more information on vasopressin/oxytocin receptor pharmacology please refer to the IUPHAR database. For further reading refer to:

Carter CS, Kenkel WM, MacLean EL, Wilson SR, Perkeybile AM, Yee JR, Ferris CF, Nazarloo HP, Porges SW, Davis JM, Connelly JJ, Kingsbury MA. Is Oxytocin
"Nature's Medicine"? Pharmacol Rev. 2020 Oct;72(4):829-861. doi: 10.1124/pr.120.019398. PMID: 32912963; PMCID: PMC7495339.

Bichet D, Bouvier M, Chini B, Gimpl G, Guillon G, Kimura T, Knepper M, Lolait S, Manning M, Mouillac B, O'Carroll AM, Serradeil-Le Gal C, Soloff M, Verbalis JG, Wheatley M, Zingg HH. Vasopressin and oxytocin receptors (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database. IUPHAR/BPS Guide to Pharmacology CITE. 2019; 2019(4).

For more information on vasopressin/oxytocin receptor pharmacology please refer to the  IUPHAR  database. For further reading refer to: Carter CS, Kenkel WM, MacLean EL, Wilson SR,... read more »
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Vasopressin/Oxytocin Receptor Antibodies

For more information on vasopressin/oxytocin receptor pharmacology please refer to the IUPHAR database. For further reading refer to:

Carter CS, Kenkel WM, MacLean EL, Wilson SR, Perkeybile AM, Yee JR, Ferris CF, Nazarloo HP, Porges SW, Davis JM, Connelly JJ, Kingsbury MA. Is Oxytocin
"Nature's Medicine"? Pharmacol Rev. 2020 Oct;72(4):829-861. doi: 10.1124/pr.120.019398. PMID: 32912963; PMCID: PMC7495339.

Bichet D, Bouvier M, Chini B, Gimpl G, Guillon G, Kimura T, Knepper M, Lolait S, Manning M, Mouillac B, O'Carroll AM, Serradeil-Le Gal C, Soloff M, Verbalis JG, Wheatley M, Zingg HH. Vasopressin and oxytocin receptors (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database. IUPHAR/BPS Guide to Pharmacology CITE. 2019; 2019(4).

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