D3 Dopamine Receptor Antibodies
The dopamine D3 receptor belongs to the D2-like subfamily of dopamine receptors. It inhibits cAMP production by coupling to inhibitory G proteins. Anti-psychotic drugs display closely similar or slightly lower antagonist affinity at D3 compared to D2 receptors. D3 desensitization, ß-arrestin recruitment and signaling are regulated by phosphorylation of third intracellular loop Serine257/threonine262. This nomenclature refers to the human D3. Phosphosite-specific antibodies can provide precise information about partial, full and biased agonism of D3 ligands. For more information on D3 receptor pharmacology please refer to the IUPHAR database. For further reading refer to:
Beaulieu JM, Gainetdinov RR. The physiology, signaling, and pharmacology of dopamine receptors. Pharmacol Rev. 2011 Mar;63(1):182-217. doi:10.1124/pr.110.002642. Epub 2011 Feb 8. Review. PubMed PMID: 21303898.
Beaulieu JM, Espinoza S, Gainetdinov RR. Dopamine receptors - IUPHAR Review 13. Br J Pharmacol. 2015 Jan;172(1):1-23. Review. PubMed PMID: 25671228; PubMed Central PMCID: PMC4280963.