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Thyrotropin-Releasing Hormone Receptor Antibodies

Thyrotropin-releasing hormone (TRH) receptors are activated by the endogenous tripeptide TRH, pyroGlu-His-Proamide, that is synthesized in the hypothalamus and released into the hypothalamic-pituitary portal circulation to act on the pituitary. TRH is produced in many other tissues, especially within the nervous system, where it appears to act as a neurotransmitter/neuromodulator. TRH and TRH analogues fail to distinguish TRH1 and TRH2 receptors. TRH1 was cloned from a mouse pituitary tumor cDNA library in 1990. The second subtype of the TRH receptor (TRH2) was identified later in rat and mouse and several other species but has not been found in humans.

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Agonist-induced Serine360 phosphorylation of the TRH1-Receptor
pS360-TRH1 (phospho-Thyrotropin-Releasing...
Serine360 (S360) is a major phosphorylation site of the TRH1 receptor. The pS360-TRH1 antibody detects phosphorylation in response to high- and low-efficacy agonists but not after PKC activation. S360 phosphorylation is primarily...
$ 375.00 *
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NEW
Agonist-induced Serine364/Threonine365 phosphorylation of the TRH1-Receptor
pS364/pT365-TRH1 (phospho-Thyrotropin-Releasing...
Serine364/Threonine365 (S364/T365) is a major phosphorylation site of the TRH1 receptor. The pS364/pT365-TRH1 antibody detects phosphorylation in response to high- and low-efficacy agonists but not after PKC activation. S364/T365...
$ 375.00 *
Details
NEW
Agonist-induced Threonine371 phosphorylation of the TRH1-Receptor
pT371-TRH1 (phospho-Thyrotropin-Releasing...
Threonine371 (T371) is a major phosphorylation site of the TRH1 receptor. The pT371-TRH1 antibody detects phosphorylation in response to high- and low-efficacy agonists but not after PKC activation. T371 phosphorylation is primarily...
$ 375.00 *
Details

For more information on TRH receptor pharmacology please refer to the IUPHAR database. For further reading refer to:

Davenport AP, Gershengorn M, Hills R. Thyrotropin-releasing hormone receptors (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database. IUPHAR/BPS Guide to Pharmacology CITE. 2019; 2019(4). Available from: https://doi.org/10.2218/gtopdb/F63/2019.4.

Alexander SP, Christopoulos A, Davenport AP, Kelly E, Mathie A, Peters JA, Veale EL et al. (2021) THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: G protein-coupled receptors. Br J Pharmacol. 176 Suppl 1:S27-S156.

For more information on TRH receptor pharmacology please refer to the IUPHAR database. For further reading refer to: Davenport AP, Gershengorn M, Hills R. Thyrotropin-releasing hormone... read more »
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Thyrotropin-Releasing Hormone Receptor Antibodies

For more information on TRH receptor pharmacology please refer to the IUPHAR database. For further reading refer to:

Davenport AP, Gershengorn M, Hills R. Thyrotropin-releasing hormone receptors (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database. IUPHAR/BPS Guide to Pharmacology CITE. 2019; 2019(4). Available from: https://doi.org/10.2218/gtopdb/F63/2019.4.

Alexander SP, Christopoulos A, Davenport AP, Kelly E, Mathie A, Peters JA, Veale EL et al. (2021) THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: G protein-coupled receptors. Br J Pharmacol. 176 Suppl 1:S27-S156.

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