CXC Chemokine Receptor 6 Antibodies

C-X-C chemokine receptor 6 (CXCR6, formerly CXCR6/Bonzo or STRL33) is a class A G protein-coupled receptor whose only known endogenous ligand is CXCL16. CXCL16 is synthesized as a transmembrane protein that can support adhesion of CXCR6-expressing cells. Proteolytic shedding, mediated principally by ADAM10, releases soluble CXCL16, which acts as a chemoattractant. CXCR6 is expressed on subsets of activated and memory T cells, including tissue-resident CD8⁺ T cells, as well as on natural killer T cells and some natural killer cells. The CXCL16–CXCR6 axis helps position and retain lymphocytes in tissues such as the liver, lung, and skin and can support antitumor T-cell responses. Inflammatory cytokines can increase CXCL16 expression, thereby regulating the availability of the ligand in inflamed tissues. Soluble CXCL16 can induce CXCR6 internalization, followed by recycling of the receptor to the cell surface. Selective small-molecule antagonists such as ML339 have been developed as preclinical research tools. No selective CXCR6 agonist or antagonist has been reported to enter clinical trials or receive approval for therapeutic use. CXCR6 desensitization, β-arrestin recruitment and internalization are regulated by phosphorylation of carboxyl-terminal serine320/serine321 (pS320/pS321-CXCR6), serine325/threonine327 (pS325/pT327-CXCR6) and serine329/serine331 (pS329/pS331-CXCR6) residues. This nomenclature refers to the human CXCR6. This phosphorylation motif is highly conserved across species and is also present in mice and rats. For more information on CXCR6 pharmacology please refer to the IUPHAR database. For further reading refer to:

Bachelerie F, Ben-Baruch A, Burkhardt AM, Combadiere C, Farber JM, Graham GJ, Horuk R, Sparre-Ulrich AH, Locati M, Luster AD, Mantovani A, Matsushima K, Murphy PM, Nibbs R, Nomiyama H, Power CA, Proudfoot AE, Rosenkilde MM, Rot A, Sozzani S, Thelen M, Yoshie O, Zlotnik A. International Union of Basic and Clinical Pharmacology. LXXXIX. Update on the extended family of chemokine receptors and introducing a new nomenclature for atypical chemokine receptors. Pharmacol Rev. 2013 Nov 11;66(1):1-79. doi: 10.1124/pr.113.007724. Print 2014. Review. Erratum in: Pharmacol Rev. 2014 Apr;66(2):467. PubMed PMID: 24218476; PubMed Central PMCID: PMC3880466.