5-HT6 Receptor Antibodies

The 5-HT6 receptor is a GPCR that couples via Gs to increase cAMP production. The receptor is structurally differentiated from the other 5-HT receptors with less than 34% amino acid sequence identity. Various selective 5-HT6 receptor antagonists have been described (e.g. SB742457) and selective agonists are becoming available (e.g. EMD386088). A number of non-selective drugs used to treat schizophrenia (e.g. olanzepine, clozapine, zotepine), also display high affinity for the 5-HT6 receptor, although the consequences of this are not clear. Selective 5-HT6 antagonists induce precognitive effects in animal models. 5-HT6 receptors are regulated by phosphorylation of carboxyl-terminal serine350/serine352 (pS350/pS352-5-HT6) and threonine355/serine356 (pT355/pS356-5-HT6) residues. This nomenclature refers to the human 5-HT6. For more information on 5-HT6 pharmacology please refer to the IUPHAR database. For further reading refer to:
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