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5-HT6 Receptor Antibodies

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Agonist-induced Serine350/Serine352 phosphorylation of the 5-Hydroxytryptamine Receptor 6
pS350/pS352-5-HT6 (phospho-5-HT Receptor 6...
Serine350/Serine352 is a major phosphorylation site of the 5-HT Receptor 6 (5-HT6). The pS350/pS352-5-HT6 antibody detects phosphorylation in response to high-efficacy agonists but not after PKC activation. S350/S352 phosphorylation is a...
$ 350.00
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Agonist-induced Threonine3545/Serine356 phosphorylation of the 5-Hydroxytryptamine Receptor 6
pT355/pS356-5-HT6 (phospho-5-HT Receptor 6...
Threonine355/Serine356 is a major phosphorylation site of the 5-HT6 receptor. The pT355/pS356-5-HT6 antibody detects phosphorylation in response to high-efficacy agonists but not after PKC activation. T355/S356 phosphorylation is a key...
$ 350.00
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Validation of the 5-Hydroxytryptamine Receptor 6 in transfected HEK293 cells
5-HT6 (non-phospho-5-HT Receptor 6 Antibody)
The non-phospho-5-HT6 receptor antibody is directed against the distal part of the carboxyl-terminal tail of human 5-Hydroxytryptamine Receptor 6 (5-HT6). It can be used to detect total 5-HT6 receptors in Western blots independent of...
$ 250.00

The 5-HT6 receptor is a GPCR that couples via Gs to increase cAMP production. The receptor is structurally differentiated from the other 5-HT receptors with less than 34% amino acid sequence identity. Various selective 5-HT6 receptor antagonists have been described (e.g. SB742457) and selective agonists are becoming available (e.g. EMD386088). A number of non-selective drugs used to treat schizophrenia (e.g. olanzepine, clozapine, zotepine), also display high affinity for the 5-HT6 receptor, although the consequences of this are not clear. Selective 5-HT6 antagonists induce precognitive effects in animal models. 5-HT6 receptors are regulated by phosphorylation of carboxyl-terminal serine350/serine352 (pS350/pS352-5-HT6) and threonine355/serine356 (pT355/pS356-5-HT6) residues. This nomenclature refers to the human 5-HT6. For more information on 5-HT6 pharmacology please refer to the IUPHAR database. For further reading refer to:

Hoyer D, Clarke DE, Fozard JR, Hartig PR, Martin GR, Mylecharane EJ, Saxena PR, Humphrey PP. International Union of Pharmacology classification of receptors for 5-hydroxytryptamine (Serotonin). Pharmacol Rev. 1994 Jun;46(2):157-203. PMID: 7938165.

Barnes NM, Ahern GP, Becamel C, Bockaert J, Camilleri M, Chaumont-Dubel S, Claeysen S, Cunningham KA, Fone KC, Gershon M, Di Giovanni G, Goodfellow NM, Halberstadt AL, Hartley RM, Hassaine G, Herrick-Davis K, Hovius R, Lacivita E, Lambe EK, Leopoldo M, Levy FO, Lummis SCR, Marin P, Maroteaux L, McCreary AC, Nelson DL, Neumaier JF, Newman-Tancredi A, Nury H, Roberts A, Roth BL, Roumier A, Sanger GJ, Teitler M, Sharp T, Villalón CM, Vogel H, Watts SW, Hoyer D. International Union of Basic and Clinical Pharmacology. CX. Classification of Receptors for 5-hydroxytryptamine; Pharmacology and Function. Pharmacol Rev. 2021 Jan;73(1):310-520. doi: 10.1124/pr.118.015552. PMID: 33370241; PMCID: PMC7770494.

Bockaert J, Claeysen S, Compan V, Dumuis A. 5-HT(4) receptors, a place in the sun: act two. Curr Opin Pharmacol. 2011 Feb;11(1):87-93. doi: 10.1016/j.coph.2011.01.012. Epub 2011 Feb 20. PMID: 21342787.

The 5-HT6 receptor is a GPCR that couples via Gs to increase cAMP production. The receptor is structurally differentiated from the other 5-HT receptors with less than 34% amino acid sequence... read more »
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5-HT6 Receptor Antibodies

The 5-HT6 receptor is a GPCR that couples via Gs to increase cAMP production. The receptor is structurally differentiated from the other 5-HT receptors with less than 34% amino acid sequence identity. Various selective 5-HT6 receptor antagonists have been described (e.g. SB742457) and selective agonists are becoming available (e.g. EMD386088). A number of non-selective drugs used to treat schizophrenia (e.g. olanzepine, clozapine, zotepine), also display high affinity for the 5-HT6 receptor, although the consequences of this are not clear. Selective 5-HT6 antagonists induce precognitive effects in animal models. 5-HT6 receptors are regulated by phosphorylation of carboxyl-terminal serine350/serine352 (pS350/pS352-5-HT6) and threonine355/serine356 (pT355/pS356-5-HT6) residues. This nomenclature refers to the human 5-HT6. For more information on 5-HT6 pharmacology please refer to the IUPHAR database. For further reading refer to:

Hoyer D, Clarke DE, Fozard JR, Hartig PR, Martin GR, Mylecharane EJ, Saxena PR, Humphrey PP. International Union of Pharmacology classification of receptors for 5-hydroxytryptamine (Serotonin). Pharmacol Rev. 1994 Jun;46(2):157-203. PMID: 7938165.

Barnes NM, Ahern GP, Becamel C, Bockaert J, Camilleri M, Chaumont-Dubel S, Claeysen S, Cunningham KA, Fone KC, Gershon M, Di Giovanni G, Goodfellow NM, Halberstadt AL, Hartley RM, Hassaine G, Herrick-Davis K, Hovius R, Lacivita E, Lambe EK, Leopoldo M, Levy FO, Lummis SCR, Marin P, Maroteaux L, McCreary AC, Nelson DL, Neumaier JF, Newman-Tancredi A, Nury H, Roberts A, Roth BL, Roumier A, Sanger GJ, Teitler M, Sharp T, Villalón CM, Vogel H, Watts SW, Hoyer D. International Union of Basic and Clinical Pharmacology. CX. Classification of Receptors for 5-hydroxytryptamine; Pharmacology and Function. Pharmacol Rev. 2021 Jan;73(1):310-520. doi: 10.1124/pr.118.015552. PMID: 33370241; PMCID: PMC7770494.

Bockaert J, Claeysen S, Compan V, Dumuis A. 5-HT(4) receptors, a place in the sun: act two. Curr Opin Pharmacol. 2011 Feb;11(1):87-93. doi: 10.1016/j.coph.2011.01.012. Epub 2011 Feb 20. PMID: 21342787.

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