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Orexin Receptor Antibodies

The orexins (orexin-A and orexin-B, also known as hypocretin-1 and hypocretin-2) are neuropeptides derived from a single precursor expressed in the posterior lateral and medial hypothalamus. These peptides were discovered independently. The name orexin (after orexis, Greek for appetite) was derived from experiments showing increased food intake after intracerebral administration of the peptides in rodents. The name hypocretin reflects their hypothalamic expression and sequence similarity to the incretin peptide family. While their effect on appetite is still controversial, and may be the result of increased arousal, orexins have a prominent role in promoting wakefulness and stabilizing vigilance state as demonstrated by pharmacological or genetic modulation of the orexin receptor signalling. Mutations in the OX2 receptor are responsible for canine narcolepsy, and orexin neuron loss is associated with the human disorder. Targeted mutagenesis of the gene encoding the orexin ligands, or genetically induced postnatal destruction of orexin-producing neurons in rodents results in a salient narcoleptic phenotype. Small molecule orexin receptor antagonists have been shown to increase sleep across species, including man. Suvorexant was the first orexin receptor antagonist approved for the treatment of insomnia.

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Agonist-induced Threonine408/Threonine409 phosphorylation of Orexin Receptor 2
pT408/pT409-OX2 (phospho-Orexin Receptor 2...
Threonine408/Threonine409 (T408/T409) is a major phosphorylation site of the Orexin receptor 2 (OX2). The pT408/pT409-OX2 antibody detects phosphorylation in response to high-efficacy agonists. T408/T409 phosphorylation is a key...
$ 350.00
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Agonist-induced Threonine401/Serine403 phosphorylation of Orexin Receptor 2
pT401/pS403-OX2 (phospho-Orexin Receptor 2...
Threonine401/Serine403 (T401/S403) is a major phosphorylation site of the Orexin receptor 2 (OX2). The pT401/pS403-OX2 antibody detects phosphorylation in response to high-efficacy agonists. T401/S403 phosphorylation is a key regulator...
$ 350.00
NEW
Agonist-induced Serine399/Serine401 phosphorylation of Orexin Receptor 1
pS399/pS401-OX1 (phospho-Orexin Receptor 1...
Serine399/Serine401 (S399/S401) is a major phosphorylation site of the Orexin receptor 1 (OX1). The pS399/pS401-OX1 antibody detects phosphorylation in response to high-efficacy agonists. S399/S401 phosphorylation is a key regulator of...
$ 350.00
NEW
Agonist-induced Serine385 phosphorylation of Orexin Receptor 1
pS385-OX1 (phospho-Orexin Receptor 1 Antibody)
Serine385 (S385) is a major phosphorylation site of the Orexin receptor 1 (OX1). The pS385-OX1 antibody detects phosphorylation in response to high-efficacy agonists. S385 phosphorylation is a key regulator of OX1 desensitization,...
$ 350.00
NEW
Agonist-induced Serine393/Serine394 phosphorylation of Orexin Receptor 1
pS393/pS394-OX1 (phospho-Orexin Receptor 1...
Serine393/Serine394 (S393/S394) is a major phosphorylation site of the Orexin receptor 1 (OX1). The pS393/pS394-OX1 antibody detects phosphorylation in response to high-efficacy agonists. S393/S394 phosphorylation is a key regulator of...
$ 350.00

For more information on chemokine receptor pharmacology please refer to the IUPHAR database. For further reading refer to:

Scammell TE, Winrow CJ. Orexin receptors: pharmacology and therapeutic opportunities. Annu Rev Pharmacol Toxicol. 2011;51:243-66. doi: 10.1146/annurev-pharmtox-010510-100528. PMID: 21034217

Coleman P, de Lecea L, Gotter A, Hagan J, Hoyer D, Kilduff T, Kukkonen JP, Porter R, Renger J, Siegel JM, Sutcliffe G, Upton N, Winrow CJ. Orexin receptors (version 2019.3) in the IUPHAR/BPS Guide to Pharmacology Database. IUPHAR/BPS Guide to Pharmacology CITE. 2019; 2019(3). Available from: https://doi.org/10.2218/gtopdb/F51/2021.3.

For more information on chemokine receptor pharmacology please refer to the  IUPHAR  database. For further reading refer to: Scammell TE, Winrow CJ. Orexin receptors: pharmacology... read more »
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Orexin Receptor Antibodies

For more information on chemokine receptor pharmacology please refer to the IUPHAR database. For further reading refer to:

Scammell TE, Winrow CJ. Orexin receptors: pharmacology and therapeutic opportunities. Annu Rev Pharmacol Toxicol. 2011;51:243-66. doi: 10.1146/annurev-pharmtox-010510-100528. PMID: 21034217

Coleman P, de Lecea L, Gotter A, Hagan J, Hoyer D, Kilduff T, Kukkonen JP, Porter R, Renger J, Siegel JM, Sutcliffe G, Upton N, Winrow CJ. Orexin receptors (version 2019.3) in the IUPHAR/BPS Guide to Pharmacology Database. IUPHAR/BPS Guide to Pharmacology CITE. 2019; 2019(3). Available from: https://doi.org/10.2218/gtopdb/F51/2021.3.

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