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Parathyroid Hormone Receptor 1 Antibodies

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Agonist-induced Threonine503/Serine504 phosphorylation of the Parathyroid Hormone Receptor 1
pT503/pS504-PTH1 (phospho-Parathyroid Hormone...
Threonine503/Serine504 (T503/S504) is major phosphorylation site of the Parathyroid Hormone Receptor 1 (PTH1). The pT503/pS504-PTH1 antibody detects phosphorylation in response to agonists. T503/S504 phosphorylation is likely to be...
$ 350.00
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Agonist-induced Serine493/Serine495 phosphorylation of the Parathyroid Hormone Receptor 1
pS493/pS495-PTH1 (phospho-Parathyroid Hormone...
Serine493/Serine495 (S493/S495) is major phosphorylation site of the Parathyroid Hormone Receptor 1 (PTH1). The pS493/pS495-PTH1 antibody detects phosphorylation in response to agonists. S493/S495 phosphorylation is likely to be involved...
$ 350.00
Citations
Validation of the Parathyroid Hormone Receptor 1 in transfected HEK293 cells
PTH1 (non-phospho-Parathyroid Hormone Receptor...
The PTH1 antibody is directed against the distal end of the carboxyl-terminal tail of human Parathyroid Hormone Receptor 1. It can be used to detect total PTH1 receptors in Western blots independent of phosphorylation. The PTH1 antibody...
$ 350.00

Most effects of PTH are mediated by PTH1 receptor, which is a member of Family B GPCRs. PTH1 receptor expression is particularly high in skeletal tissues and kidney but it has a nearly ubiquitous tissue distribution. PTH1 receptor signaling via Gs or Gq is regulated in a cell- and ligand-specific manner by β-arrestins and the PDZ protein NHERF1. PTH1 activity is regulated by phosphorylation of carboxyl-terminal serine493/serine495 (pS493/pS495-PTH1) and threonine503/serine504 (pT503/pS504-PTH1). This nomenclature refers to the human PTH1 receptor. This phosphorylation motif is highly conserved and is identical in mice, rats and humans. For more information on PTH1 pharmacology please refer to the IUPHAR database. For further reading refer to:

Gardella TJ, Vilardaga JP. International Union of Basic and Clinical Pharmacology. XCIII. The parathyroid hormone receptors--family B G protein-coupled receptors. Pharmacol Rev. 2015;67(2):310-37. doi: 10.1124/pr.114.009464. PMID: 25713287; PMCID: PMC4394688.

Most effects of PTH are mediated by PTH1 receptor, which is a member of Family B GPCRs. PTH1 receptor expression is particularly high in skeletal tissues and kidney but it has a nearly... read more »
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Parathyroid Hormone Receptor 1 Antibodies

Most effects of PTH are mediated by PTH1 receptor, which is a member of Family B GPCRs. PTH1 receptor expression is particularly high in skeletal tissues and kidney but it has a nearly ubiquitous tissue distribution. PTH1 receptor signaling via Gs or Gq is regulated in a cell- and ligand-specific manner by β-arrestins and the PDZ protein NHERF1. PTH1 activity is regulated by phosphorylation of carboxyl-terminal serine493/serine495 (pS493/pS495-PTH1) and threonine503/serine504 (pT503/pS504-PTH1). This nomenclature refers to the human PTH1 receptor. This phosphorylation motif is highly conserved and is identical in mice, rats and humans. For more information on PTH1 pharmacology please refer to the IUPHAR database. For further reading refer to:

Gardella TJ, Vilardaga JP. International Union of Basic and Clinical Pharmacology. XCIII. The parathyroid hormone receptors--family B G protein-coupled receptors. Pharmacol Rev. 2015;67(2):310-37. doi: 10.1124/pr.114.009464. PMID: 25713287; PMCID: PMC4394688.

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