C5a Complement Peptide Receptor 2 Antibodies

Complement C5a receptor 2 (C5aR2), formerly known as C5L2 or GPR77 and encoded by C5AR2, is an atypical member of the class A G protein-coupled receptor family. It binds both the complement anaphylatoxin C5a and its carboxypeptidase-generated metabolite C5a-desArg. C5aR2 shows little or no detectable coupling to conventional heterotrimeric G proteins, but both ligands can enhance its association with β-arrestin 2. The receptor is expressed in myeloid cells, including neutrophils, monocytes, and macrophages, and can be predominantly intracellular in some cell types. C5aR2 can modulate C5aR1-dependent responses such as ERK activation and neutrophil chemotaxis. Its effects on inflammation vary with the cell type and disease model, with both pro- and anti-inflammatory effects reported. The synthetic peptides P32 and P59 are experimental agonists that preferentially recruit β-arrestin 2 through C5aR2. No C5aR2-selective ligand has been reported to enter clinical trials or receive approval for therapeutic use. Efficient ligand uptake by C5a2 critically depends on phosphorylation of carboxyl-terminal serine326/threonine327 (pS326/pT327-C5a2). For more information on C5a2 receptor pharmacology please refer to the IUPHAR database. For further reading refer to:

Klos A, Wende E, Wareham KJ, Monk PN. International Union of Basic and Clinical Pharmacology. [corrected]. LXXXVII. Complement peptide C5a, C4a, and C3a receptors. Pharmacol Rev. 2013 Jan;65(1):500-43. Review. Erratum in: Pharmacol Rev. 2014 Apr;66(2):466. PubMed PMID: 23383423.