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Free Fatty Acid Receptor 2 Antibodies

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Immunohistochemical Identification of Threonine306/Threonine310 phosphorylation of the FFA Receptor 2 in mouse neuroendocrine cells and peyer's patches.
pT306/pT310-FFA2 (IHC-grade phospho-FFA2 Antibody)
Threonine306/Threonine310 (T306/T310) is major phosphorylation site of the FFA 2 Receptor (FFA2). The pT306/pT310-FFA2 antibody detects phosphorylation in response to agonists. T306/T310 phosphorylation is likely to be involved in...
$ 500.00 *
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NEW
Agonist-induced Threonine306/Threonine310 phosphorylation of the FFA2 Receptor
pT306/pT310-FFA2 (phospho-FFA2 Antibody)
Threonine306/Threonine310 (T306/T310) is major phosphorylation site of the FFA 2 Receptor (FFA2). The pT306/pT310-FFA2 antibody detects phosphorylation in response to agonists. T306/T310 phosphorylation is likely to be involved in...
$ 375.00 *
Details
NEW
Constitutive Serine296/Serine297 phosphorylation of the FFA Receptor 2
pS296/pS297-FFA2 (phospho-FFA2 Antibody)
Serine296/Serine297 (S296/S297) is major phosphorylation site of the FFA Receptor 2 (FFA2). The pS296/pS297-FFA2 antibody detects constitutive phosphorylation of FFA2.
$ 375.00 *
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NEW
Immunohistochemical Identification of Serine296/Serine297 phosphorylation of the FFA Receptor 2 in mouse white adipose tissue and peyer's patches.
pS296/pS297-FFA2 (IHC-grade phospho-FFA2 Antibody)
Serine296/Serine297 (S296/S297) is major phosphorylation site of the FFA Receptor 2 (FFA2). The pS296/pS297-FFA2 antibody detects constitutive phosphorylation of FFA2.
$ 500.00 *
Details
NEW
Validation of the FFA2 in transfected HEK293 cells
FFA2 (non-phospho-FFA2 Antibody)
The non-phospho-FFA2 receptor antibody is directed against the distal part of the carboxyl-terminal tail of human FFA2. It can be used to detect total FFA2 receptors in Western blots independent of phosphorylation. The non-phospho-FFA2...
$ 375.00 *
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Citations
KO-Validated
Immunohistochemical identification of FFA2 Receptor in pancreas
FFA2 (IHC-grade), FFA2 Receptor Antibody
The FFA2 receptor antibody is directed against the distal part of the carboxyl-terminal tail of human FFA2. It can be used to detect total FFA2 receptors in Western blots independent of phosphorylation. The FFA2 antibody can also be used...
$ 375.00 *
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Free fatty acid receptor 2 (FFA2, formerly GPR43), encoded by FFAR2, is a class A G protein-coupled receptor activated by short-chain fatty acids, particularly acetate and propionate. These ligands are produced in large amounts by gut bacteria during fermentation of dietary fiber. FFA2 couples to both Gi/o and Gq/11, allowing it to inhibit adenylyl cyclase or mobilize intracellular calcium, depending on the cellular context. The receptor is expressed on neutrophils and other immune cells, as well as in intestinal enteroendocrine cells and adipose tissue. FFA2 activation can promote neutrophil chemotaxis and contribute to glucagon-like peptide-1 (GLP-1) secretion from intestinal L cells. Agonist stimulation can induce β-arrestin recruitment and receptor internalization, while allosteric ligands such as AZ1729 can preferentially enhance Gi/o signaling in some experimental systems. The oral small-molecule antagonist GLPG0974 was evaluated in a phase 2 proof-of-concept study in ulcerative colitis. No FFA2-selective drug is currently approved for therapeutic use. FFA2 receptor desensitization, β-arrestin recruitment and internalization are regulated by phosphorylation of carboxyl-terminal serine296/serine297 (pS296/pS297-FFA2) and threonine306/threonine310 (pT306/pT310-FFA2). This nomenclature refers to the human FFA2 receptor. For more information on FFA2 pharmacology please refer to the IUPHAR database. For further reading refer to:

Stoddart LA, Smith NJ, Milligan G. International Union of Pharmacology. LXXI. Free fatty acid receptors FFA1, -2, and -3: pharmacology and pathophysiological functions. Pharmacol Rev. 2008 Dec;60(4):405-17. doi: 10.1124/pr.108.00802. Epub 2008 Dec 1. PMID: 19047536.

Riddy DM, Delerive P, Summers RJ, Sexton PM, Langmead CJ. G Protein-Coupled Receptors Targeting Insulin Resistance, Obesity, and Type 2 Diabetes Mellitus. Pharmacol Rev. 2018 Jan;70(1):39-67. doi: 10.1124/pr.117.014373. PMID: 29233848.

Barki N, Jenkins L, Marsango S, Dedeo D, Bolognini D, Dwomoh L, Abdelmalik AM, Nilsen M, Stoffels M, Nagel F, Schulz S, Tobin AB, Milligan G. Phosphorylation bar-coding of free fatty acid receptor 2 is generated in a tissue-specific manner. Elife. 2023 Dec 12;12:RP91861. doi: 10.7554/eLife.91861. PMID: 38085667; PMCID: PMC10715726.

Ruhnke N, Beyer AL, Kaemmerer D, Sänger J, Schulz S, Lupp A. Expression of free fatty acid receptor 2 in normal and neoplastic tissues. Exp Mol Pathol. 2024 Jun;137:104902. doi: 10.1016/j.yexmp.2024.104902. Epub 2024 May 23. PMID: 38788249.

Free fatty acid receptor 2 (FFA2, formerly GPR43), encoded by FFAR2 , is a class A G protein-coupled receptor activated by short-chain fatty acids, particularly acetate and propionate. These... read more »
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Free Fatty Acid Receptor 2 Antibodies

Free fatty acid receptor 2 (FFA2, formerly GPR43), encoded by FFAR2, is a class A G protein-coupled receptor activated by short-chain fatty acids, particularly acetate and propionate. These ligands are produced in large amounts by gut bacteria during fermentation of dietary fiber. FFA2 couples to both Gi/o and Gq/11, allowing it to inhibit adenylyl cyclase or mobilize intracellular calcium, depending on the cellular context. The receptor is expressed on neutrophils and other immune cells, as well as in intestinal enteroendocrine cells and adipose tissue. FFA2 activation can promote neutrophil chemotaxis and contribute to glucagon-like peptide-1 (GLP-1) secretion from intestinal L cells. Agonist stimulation can induce β-arrestin recruitment and receptor internalization, while allosteric ligands such as AZ1729 can preferentially enhance Gi/o signaling in some experimental systems. The oral small-molecule antagonist GLPG0974 was evaluated in a phase 2 proof-of-concept study in ulcerative colitis. No FFA2-selective drug is currently approved for therapeutic use. FFA2 receptor desensitization, β-arrestin recruitment and internalization are regulated by phosphorylation of carboxyl-terminal serine296/serine297 (pS296/pS297-FFA2) and threonine306/threonine310 (pT306/pT310-FFA2). This nomenclature refers to the human FFA2 receptor. For more information on FFA2 pharmacology please refer to the IUPHAR database. For further reading refer to:

Stoddart LA, Smith NJ, Milligan G. International Union of Pharmacology. LXXI. Free fatty acid receptors FFA1, -2, and -3: pharmacology and pathophysiological functions. Pharmacol Rev. 2008 Dec;60(4):405-17. doi: 10.1124/pr.108.00802. Epub 2008 Dec 1. PMID: 19047536.

Riddy DM, Delerive P, Summers RJ, Sexton PM, Langmead CJ. G Protein-Coupled Receptors Targeting Insulin Resistance, Obesity, and Type 2 Diabetes Mellitus. Pharmacol Rev. 2018 Jan;70(1):39-67. doi: 10.1124/pr.117.014373. PMID: 29233848.

Barki N, Jenkins L, Marsango S, Dedeo D, Bolognini D, Dwomoh L, Abdelmalik AM, Nilsen M, Stoffels M, Nagel F, Schulz S, Tobin AB, Milligan G. Phosphorylation bar-coding of free fatty acid receptor 2 is generated in a tissue-specific manner. Elife. 2023 Dec 12;12:RP91861. doi: 10.7554/eLife.91861. PMID: 38085667; PMCID: PMC10715726.

Ruhnke N, Beyer AL, Kaemmerer D, Sänger J, Schulz S, Lupp A. Expression of free fatty acid receptor 2 in normal and neoplastic tissues. Exp Mol Pathol. 2024 Jun;137:104902. doi: 10.1016/j.yexmp.2024.104902. Epub 2024 May 23. PMID: 38788249.

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