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Free Fatty Acid Receptor 3 Antibodies

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Agonist-induced Serine305/Serine306 phosphorylation of the FFA Receptor 3
pS305/pS306-FFA3 (phospho-FFA3 Antibody)
Serine305/Serine306 (S305/S306) is major phosphorylation site of the FFA Receptor 3 (FFA3). The pS305/pS306-FFA3 antibody detects phosphorylation in response to agonists. S305/S306 phosphorylation is likely to be involved in efficient...
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Agonist-induced Threonine328/Serine329 phosphorylation of the FFA Receptor 3
pT328/pS329-FFA3 (phospho-FFA3 Antibody)
Threonine328/Serine329 (T328/S329) is major phosphorylation site of the FFA Receptor 3 (FFA3). The pT328/pS329-FFA3 antibody detects phosphorylation in response to agonists. T328/S329 phosphorylation is likely to be involved in efficient...
$ 375.00 *
Details

The expression of FFA3 in adipose is supported by expression of the receptor in differentiated human and mouse adipocytes, whilst little expression was observed in pre-adipocytes or brown fat. Moreover, expression of the receptor in various other cell-types including dendritic cells, lymphocytes, peripheral blood mononuclear cells and artery and arteriolar endothelial cells raises further questions as to the role of the receptor in immune cell function. FFA3 differs from FFA2 most notably in its rank order potency of preferred ligands and G protein-coupling. Propionate is the most potent ligand for FFA3 followed by butyrate and pentanoate respectively. Activation of FFA3 by propionate via a pertussis-toxin sensitive Gαi-coupled pathway, was reported to elevate leptin production from mouse adipocytes and primary adipocyte tissue cultures. FFA3 receptor desensitization, β-arrestin recruitment and internalization are regulated by phosphorylation of carboxyl-terminal serine305/serine306 (pS305/pS306-FFA3) and threonine328/serine329 (pT328/pS329-FFA3). This nomenclature refers to the human FFA3 receptor. For more information on FFA3 pharmacology please refer to the IUPHAR database. For further reading refer to:

Stoddart LA, Smith NJ, Milligan G. International Union of Pharmacology. LXXI. Free fatty acid receptors FFA1, -2, and -3: pharmacology and pathophysiological functions. Pharmacol Rev. 2008 Dec;60(4):405-17. doi: 10.1124/pr.108.00802. Epub 2008 Dec 1. PMID: 19047536.

Riddy DM, Delerive P, Summers RJ, Sexton PM, Langmead CJ. G Protein-Coupled Receptors Targeting Insulin Resistance, Obesity, and Type 2 Diabetes Mellitus. Pharmacol Rev. 2018 Jan;70(1):39-67. doi: 10.1124/pr.117.014373. PMID: 29233848.

The expression of FFA3 in adipose is supported by expression of the receptor in differentiated human and mouse adipocytes, whilst little expression was observed in pre-adipocytes or brown fat.... read more »
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Free Fatty Acid Receptor 3 Antibodies

The expression of FFA3 in adipose is supported by expression of the receptor in differentiated human and mouse adipocytes, whilst little expression was observed in pre-adipocytes or brown fat. Moreover, expression of the receptor in various other cell-types including dendritic cells, lymphocytes, peripheral blood mononuclear cells and artery and arteriolar endothelial cells raises further questions as to the role of the receptor in immune cell function. FFA3 differs from FFA2 most notably in its rank order potency of preferred ligands and G protein-coupling. Propionate is the most potent ligand for FFA3 followed by butyrate and pentanoate respectively. Activation of FFA3 by propionate via a pertussis-toxin sensitive Gαi-coupled pathway, was reported to elevate leptin production from mouse adipocytes and primary adipocyte tissue cultures. FFA3 receptor desensitization, β-arrestin recruitment and internalization are regulated by phosphorylation of carboxyl-terminal serine305/serine306 (pS305/pS306-FFA3) and threonine328/serine329 (pT328/pS329-FFA3). This nomenclature refers to the human FFA3 receptor. For more information on FFA3 pharmacology please refer to the IUPHAR database. For further reading refer to:

Stoddart LA, Smith NJ, Milligan G. International Union of Pharmacology. LXXI. Free fatty acid receptors FFA1, -2, and -3: pharmacology and pathophysiological functions. Pharmacol Rev. 2008 Dec;60(4):405-17. doi: 10.1124/pr.108.00802. Epub 2008 Dec 1. PMID: 19047536.

Riddy DM, Delerive P, Summers RJ, Sexton PM, Langmead CJ. G Protein-Coupled Receptors Targeting Insulin Resistance, Obesity, and Type 2 Diabetes Mellitus. Pharmacol Rev. 2018 Jan;70(1):39-67. doi: 10.1124/pr.117.014373. PMID: 29233848.

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