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Free Fatty Acid Receptor 3 Antibodies

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Agonist-induced Serine305/Serine306 phosphorylation of the FFA Receptor 3
pS305/pS306-FFA3 (phospho-FFA3 Antibody)
Serine305/Serine306 (S305/S306) is major phosphorylation site of the FFA Receptor 3 (FFA3). The pS305/pS306-FFA3 antibody detects phosphorylation in response to agonists. S305/S306 phosphorylation is likely to be involved in efficient...
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Agonist-induced Threonine328/Serine329 phosphorylation of the FFA Receptor 3
pT328/pS329-FFA3 (phospho-FFA3 Antibody)
Threonine328/Serine329 (T328/S329) is major phosphorylation site of the FFA Receptor 3 (FFA3). The pT328/pS329-FFA3 antibody detects phosphorylation in response to agonists. T328/S329 phosphorylation is likely to be involved in efficient...
$ 375.00 *
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Validation of the FFA3 in transfected HEK293 cells.
FFA3 (non-phospho-FFA3 Antibody)
The non-phospho-FFA3 receptor antibody is directed against the distal part of the carboxyl-terminal tail of human FFA3. It can be used to detect total FFA3 receptors in Western blots independent of phosphorylation. The non-phospho-FFA3...
$ 375.00 *
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Validation of the mouse FFA3 in transfected HEK293 cells.
mFFA3 (non-phospho-Mouse FFA3 Antibody)
The non-phospho-FFA3 receptor antibody is directed against the distal part of the carboxyl-terminal tail of mouse FFA3. It can be used to detect total FFA3 receptors in Western blots independent of phosphorylation. The non-phospho-FFA3...
$ 375.00 *
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Free fatty acid receptor 3 (FFA3, formerly GPR41), encoded by FFAR3, is a class A G protein-coupled receptor activated by short-chain fatty acids. Propionate and butyrate are generally more potent agonists than acetate, and all three are produced during microbial fermentation in the gut. FFA3 couples predominantly to Gi/o, inhibiting adenylyl cyclase and reducing intracellular cAMP. Its expression has been reported in intestinal enteroendocrine cells and peripheral neurons, including enteric and sympathetic neurons. Experimental studies link FFA3 activation to changes in intestinal hormone release, motility, and secretion. In rodents, FFA3 signaling in sympathetic ganglia has also been implicated in the regulation of energy expenditure. The mechanisms governing FFA3 phosphorylation, desensitization, and trafficking in native cells remain incompletely characterized. The synthetic agonist AR420626 is used to study FFA3 function in preclinical models. No FFA3-selective drug has been reported to enter clinical trials or receive approval for therapeutic use. FFA3 receptor desensitization, β-arrestin recruitment and internalization are regulated by phosphorylation of carboxyl-terminal serine305/serine306 (pS305/pS306-FFA3) and threonine328/serine329 (pT328/pS329-FFA3). This nomenclature refers to the human FFA3 receptor. For more information on FFA3 pharmacology please refer to the IUPHAR database. For further reading refer to:

Stoddart LA, Smith NJ, Milligan G. International Union of Pharmacology. LXXI. Free fatty acid receptors FFA1, -2, and -3: pharmacology and pathophysiological functions. Pharmacol Rev. 2008 Dec;60(4):405-17. doi: 10.1124/pr.108.00802. Epub 2008 Dec 1. PMID: 19047536.

Riddy DM, Delerive P, Summers RJ, Sexton PM, Langmead CJ. G Protein-Coupled Receptors Targeting Insulin Resistance, Obesity, and Type 2 Diabetes Mellitus. Pharmacol Rev. 2018 Jan;70(1):39-67. doi: 10.1124/pr.117.014373. PMID: 29233848.

Free fatty acid receptor 3 (FFA3, formerly GPR41), encoded by FFAR3 , is a class A G protein-coupled receptor activated by short-chain fatty acids. Propionate and butyrate are generally more... read more »
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Free Fatty Acid Receptor 3 Antibodies

Free fatty acid receptor 3 (FFA3, formerly GPR41), encoded by FFAR3, is a class A G protein-coupled receptor activated by short-chain fatty acids. Propionate and butyrate are generally more potent agonists than acetate, and all three are produced during microbial fermentation in the gut. FFA3 couples predominantly to Gi/o, inhibiting adenylyl cyclase and reducing intracellular cAMP. Its expression has been reported in intestinal enteroendocrine cells and peripheral neurons, including enteric and sympathetic neurons. Experimental studies link FFA3 activation to changes in intestinal hormone release, motility, and secretion. In rodents, FFA3 signaling in sympathetic ganglia has also been implicated in the regulation of energy expenditure. The mechanisms governing FFA3 phosphorylation, desensitization, and trafficking in native cells remain incompletely characterized. The synthetic agonist AR420626 is used to study FFA3 function in preclinical models. No FFA3-selective drug has been reported to enter clinical trials or receive approval for therapeutic use. FFA3 receptor desensitization, β-arrestin recruitment and internalization are regulated by phosphorylation of carboxyl-terminal serine305/serine306 (pS305/pS306-FFA3) and threonine328/serine329 (pT328/pS329-FFA3). This nomenclature refers to the human FFA3 receptor. For more information on FFA3 pharmacology please refer to the IUPHAR database. For further reading refer to:

Stoddart LA, Smith NJ, Milligan G. International Union of Pharmacology. LXXI. Free fatty acid receptors FFA1, -2, and -3: pharmacology and pathophysiological functions. Pharmacol Rev. 2008 Dec;60(4):405-17. doi: 10.1124/pr.108.00802. Epub 2008 Dec 1. PMID: 19047536.

Riddy DM, Delerive P, Summers RJ, Sexton PM, Langmead CJ. G Protein-Coupled Receptors Targeting Insulin Resistance, Obesity, and Type 2 Diabetes Mellitus. Pharmacol Rev. 2018 Jan;70(1):39-67. doi: 10.1124/pr.117.014373. PMID: 29233848.

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