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Free Fatty Acid Receptor 4 Antibodies

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Agonist-induced Threonine347 phosphorylation of the FFA Receptor 4
pT347-FFA4 (phospho-FFA4 Antibody)
Threonine347 (T347) is major phosphorylation site of the FFA Receptor 4 (FFA4). The pT347-FFA4 antibody detects phosphorylation in response to agonists. T347 phosphorylation is likely to be involved in efficient ligand sequestration by...
$ 375.00 *
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Agonist-induced Threonine349/Serine350 phosphorylation of the FFA Receptor 4
pT349/pS350-FFA4 (phospho-FFA4 Antibody)
Threonine349/Serine350 (T349/S350) is major phosphorylation site of the FFA Receptor 4 (FFA4). The pT349/pS350-FFA4 antibody detects phosphorylation in response to agonists. T349/S350 phosphorylation is likely to be involved in efficient...
$ 375.00 *
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Detection of non-phosphorylated human FFA4 Receptor
FFA4 (non-phospho-FFA4 Antibody)
The non-phospho-FFA4 receptor antibody is directed against the distal part of the carboxyl-terminal tail of human FFA4. It can be used to detect total FFA4 receptors in Western blots independent of phosphorylation. The non-phospho-FFA4...
$ 375.00 *
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Immunohistochemical identification of FFA4 Receptor in human spleen
FFA4 (IHC-grade), FFA4 Receptor Antibody
The FFA4 receptor antibody is directed against the distal part of the carboxyl-terminal tail of human FFA4. It can be used to detect total FFA4 receptors in Western blots independent of phosphorylation. The FFA4 antibody can also be used...
$ 375.00 *
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FFA4

Free fatty acid receptor 4 (FFA4, formerly GPR120), encoded by FFAR4, is a class A G protein-coupled receptor activated by medium- and long-chain fatty acids, including the omega-3 fatty acids eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA). The short human splice isoform, FFA4-S, couples predominantly to Gq/11 and mobilizes intracellular calcium. The long isoform, FFA4-L, contains a 16-amino-acid insertion in the third intracellular loop and preferentially signals through β-arrestins in recombinant systems. FFA4 is expressed in intestinal enteroendocrine cells, adipocytes, and macrophages. Experimental studies link its activation to gut hormone secretion, glucose homeostasis, and modulation of inflammatory responses. Agonist-induced phosphorylation of the receptor’s C-terminal tail regulates β-arrestin recruitment and receptor trafficking. The synthetic agonist TUG-891 is a widely used research tool with greater selectivity for human FFA4 over FFA1 than for the corresponding mouse receptors. No FFA4-selective drug is currently approved for therapeutic use. FFA4 receptor desensitization, β-arrestin recruitment and internalization are regulated by phosphorylation of carboxyl-terminal threonine347 (pT347-FFA4) and threonine349/serine350 (pT349/pS350-FFA4). This nomenclature refers to the human FFA4 receptor. For more information on FFA4 pharmacology please refer to the IUPHAR database. For further reading refer to:

Stoddart LA, Smith NJ, Milligan G. International Union of Pharmacology. LXXI. Free fatty acid receptors FFA1, -2, and -3: pharmacology and pathophysiological functions. Pharmacol Rev. 2008 Dec;60(4):405-17. doi: 10.1124/pr.108.00802. Epub 2008 Dec 1. PMID: 19047536.

Riddy DM, Delerive P, Summers RJ, Sexton PM, Langmead CJ. G Protein-Coupled Receptors Targeting Insulin Resistance, Obesity, and Type 2 Diabetes Mellitus. Pharmacol Rev. 2018 Jan;70(1):39-67. doi: 10.1124/pr.117.014373. PMID: 29233848.

Free fatty acid receptor 4 (FFA4, formerly GPR120), encoded by FFAR4 , is a class A G protein-coupled receptor activated by medium- and long-chain fatty acids, including the omega-3 fatty... read more »
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Free Fatty Acid Receptor 4 Antibodies

FFA4

Free fatty acid receptor 4 (FFA4, formerly GPR120), encoded by FFAR4, is a class A G protein-coupled receptor activated by medium- and long-chain fatty acids, including the omega-3 fatty acids eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA). The short human splice isoform, FFA4-S, couples predominantly to Gq/11 and mobilizes intracellular calcium. The long isoform, FFA4-L, contains a 16-amino-acid insertion in the third intracellular loop and preferentially signals through β-arrestins in recombinant systems. FFA4 is expressed in intestinal enteroendocrine cells, adipocytes, and macrophages. Experimental studies link its activation to gut hormone secretion, glucose homeostasis, and modulation of inflammatory responses. Agonist-induced phosphorylation of the receptor’s C-terminal tail regulates β-arrestin recruitment and receptor trafficking. The synthetic agonist TUG-891 is a widely used research tool with greater selectivity for human FFA4 over FFA1 than for the corresponding mouse receptors. No FFA4-selective drug is currently approved for therapeutic use. FFA4 receptor desensitization, β-arrestin recruitment and internalization are regulated by phosphorylation of carboxyl-terminal threonine347 (pT347-FFA4) and threonine349/serine350 (pT349/pS350-FFA4). This nomenclature refers to the human FFA4 receptor. For more information on FFA4 pharmacology please refer to the IUPHAR database. For further reading refer to:

Stoddart LA, Smith NJ, Milligan G. International Union of Pharmacology. LXXI. Free fatty acid receptors FFA1, -2, and -3: pharmacology and pathophysiological functions. Pharmacol Rev. 2008 Dec;60(4):405-17. doi: 10.1124/pr.108.00802. Epub 2008 Dec 1. PMID: 19047536.

Riddy DM, Delerive P, Summers RJ, Sexton PM, Langmead CJ. G Protein-Coupled Receptors Targeting Insulin Resistance, Obesity, and Type 2 Diabetes Mellitus. Pharmacol Rev. 2018 Jan;70(1):39-67. doi: 10.1124/pr.117.014373. PMID: 29233848.

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