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NEW
pS326/pS328-AT1 (phospho-Angiotensin Receptor 1... Serine326/Serine328 (S326/S328) is major phosphorylation site of the Angiotensin Receptor 1 (AT1). The pS326/pS328-AT1 antibody detects phosphorylation in response to agonists. S326/S328 phosphorylation is likely to be involved in...
$ 375.00 *
NEW
pS348/pT349-AT1 (phospho-Angiotensin Receptor 1... Serine348/Threonine349 (S348/T349) is major phosphorylation site of the Angiotensin Receptor 1 (AT1). The pS348/pT349-AT1 antibody detects phosphorylation in response to agonists. S348/T349 phosphorylation is likely to be involved in...
$ 375.00 *
NEW
pS338/pS342-AT1 (phospho-Angiotensin Receptor 1... Serine338/Serine342 (S338/S342) is major phosphorylation site of the Angiotensin Receptor 1 (AT1). The pS338/pS342-AT1 antibody detects phosphorylation in response to agonists. S338/S342 phosphorylation is likely to be involved in...
$ 375.00 *
NEW
pS331/pT332-AT1 (phospho-Angiotensin Receptor 1... Serine331/Threonine332 (S331/T332) is major phosphorylation site of the Angiotensin Receptor 1 (AT1). The pS331/pT332-AT1 antibody detects phosphorylation in response to agonists. S331/T332 phosphorylation is likely to be involved in...
$ 375.00 *
SAMPLE PACK
AT1 Sample Pack (phospho- and... AT1 Sample Pack consisting of all four available phospho- and non-phospho-AT1 Antibodies 7 x 20 µL trial size each.
$ 300.00 *
NEW
pS346/pS347-AT1 (phospho-Angiotensin Receptor 1... Serine346/Serine347 (S346/S347) is major phosphorylation site of the Angiotensin Receptor 1 (AT1). The pS346/pS347-AT1 antibody detects phosphorylation in response to agonists. S346/S347 phosphorylation is likely to be involved in...
$ 375.00 *
NEW
pS335/pT336-AT1 (phospho-Angiotensin Receptor 1... Serine335/Threonine336 (S335/T336) is major phosphorylation site of the Angiotensin Receptor 1 (AT1). The pS335/pT336-AT1 antibody detects phosphorylation in response to agonists. S335/T336 phosphorylation is likely to be involved in...
$ 375.00 *
NEW
AT1 (GP-non-phospho) Angiotensin Receptor 1... The non-phospho-AT1 receptor antibody is directed against the distal part of the carboxyl-terminal tail of human Angiotensin Receptor 1 (AT1). It can be used to detect total AT1 receptors in Western blots independent of phosphorylation....
$ 375.00 *
NEW
AT1 (non-phospho-Angiotensin Receptor 1 Antibody) The non-phospho-AT1 receptor antibody is directed against the distal part of the carboxyl-terminal tail of human Angiotensin Receptor 1 (AT1). It can be used to detect total AT1 receptors in Western blots independent of phosphorylation....
$ 375.00 *
The angiotensin II type 1 receptor (AT₁R), encoded by AGTR1, is a class A G protein-coupled receptor activated by the endogenous peptide angiotensin II. It is expressed in vascular smooth muscle, the kidneys, the adrenal cortex, and the heart. AT₁R signals predominantly through Gq/11, activating phospholipase C and increasing intracellular calcium. This pathway contributes to vasoconstriction and aldosterone secretion, while renal AT₁R signaling promotes sodium retention. Sustained AT₁R activation can promote inflammation, fibrosis, and cardiovascular remodeling. Agonist-induced phosphorylation by GRK2/3 and GRK5/6 promotes β-arrestin recruitment, which contributes to receptor desensitization and internalization. The synthetic peptide TRV027 preferentially recruits β-arrestin over activating G proteins and has been evaluated in clinical trials, including in acute heart failure. Selective AT₁R antagonists such as losartan, valsartan, and candesartan are used clinically to treat hypertension and, depending on the drug, heart failure or diabetic kidney disease. Intravenous angiotensin II is approved as a vasopressor for adults with septic or other distributive shock. AT1 receptor desensitization, β-arrestin recruitment and internalization are regulated by phosphorylation of carboxyl-terminal serine326/serine328 (pS326/pS328-AT1), serine331/threonine332 (pS331/pT332-AT1), serine335/threonine336 (pS335/pT336-AT1), serine338/serine342 (pS338/pS342-AT1), serine346/serine347 (pS346/pS347-AT1), and serine348/serine349 (pS348/pS349-AT1. This nomenclature refers to the human AT1 receptor. For more information on AT1 pharmacology please refer to the Recently viewed