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Sphingosine 1-Phosphate Receptor Antibodies

Sphingosine 1-phosphate (S1P) receptors are activated by the endogenous lipid sphingosine 1-phosphate. The receptors are designated as S1P1 through S1P5 receptors. S1P receptors, particularly S1P1, are expressed throughout all mammalian organ systems. Ligand delivery occurs via two known carriers: albumin and HDL-bound apolipoprotein M. Fingolimod (FTY720) binds as a phosphorylated metabolite to four of the five S1P receptors, and was the first oral therapy for multiple sclerosis (MS). Second-generation S1PR modulators siponimod, ozanimod, and ponesimod that target S1P1 and S1P5 are also FDA approved for the treatment of various MS forms. In 2021, ozanimod became the first S1P receptor modulator to be FDA approved for the treatment of ulcerative colitis. The mechanisms of action of fingolimod and other S1P receptor-modulating drugs now in development include binding S1P receptors in multiple organ systems, e.g., immune and nervous systems, although the precise nature of their receptor interactions requires further clarification.

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Agonist-induced Serine351/Serine353 phosphorylation of the Sphingosine 1-Phosphate Receptor 1
pS351/pS353-S1P1 (phospho-Sphingosine...
Serine351/Serine353 (S351/S353) is major phosphorylation site of the Sphingosine 1-Phosphate Receptor 1 (S1P1). The pS351/pS353-S1P1 antibody detects phosphorylation in response to agonists. S351/S353 phosphorylation is likely to be...
$ 350.00 *
NEW
Agonist-induced Serine353/Serine355 phosphorylation of the Sphingosine 1-Phosphate Receptor 1
pS353/pS355-S1P1 (phospho-Sphingosine...
Serine353/Serine355 (S353/S355) is major phosphorylation site of the Sphingosine 1-Phosphate Receptor 1 (S1P1). The pS353/pS355-S1P1 antibody detects phosphorylation in response to agonists. S353/S355 phosphorylation is likely to be...
$ 350.00 *
NEW
Agonist-induced Serine358/Serine359 phosphorylation of the Sphingosine 1-Phosphate Receptor 1
pS358/pS359-S1P1 (phospho-Sphingosine...
Serine358/Serine359 (S358/S359) is major phosphorylation site of the Sphingosine 1-Phosphate Receptor 1 (S1P1). The pS358/pS359-S1P1 antibody detects phosphorylation in response to agonists. S358/S359 phosphorylation is likely to be...
$ 350.00 *
NEW
Agonist-induced Serine330/Serine331 phosphorylation of the Sphingosine 1-Phosphate Receptor 2
pS330/pS331-S1P2 (phospho-Sphingosine...
Serine330/Serine331 (S330/S331) is major phosphorylation site of the Sphingosine 1-Phosphate Receptor 2 (S1P2). The pS330/pS331-S1P2 antibody detects phosphorylation in response to agonists. S330/S331 phosphorylation is likely to be...
$ 350.00 *
NEW
pT342/pS343/pT345-S1P2 (phospho-Sphingosine 1-Phosphate Receptor 2 Antibody)
pT342/pS343/pT345-S1P2 (phospho-Sphingosine...
Threonine342Serine343/Threonine345 (T342/S343/T345) is major phosphorylation site of the Sphingosine 1-Phosphate Receptor 2 (S1P2). The pT342/pS343/pT345-S1P2 antibody detects phosphorylation in response to agonists. T342/S343/T345...
$ 350.00 *
NEW
Agonist-induced Serine335/Serine337 phosphorylation of the Sphingosine 1-Phosphate Receptor 3
pS335/pS337-S1P3 (phospho-Sphingosine...
Serine335/Serine337 (S335/S337) is major phosphorylation site of the Sphingosine 1-Phosphate Receptor 3 (S1P3). The pS335/pS337-S1P3 antibody detects phosphorylation in response to agonists. S335/S337 phosphorylation is likely to be...
$ 350.00 *
NEW
Agonist-induced Serine364/Serine366/Serine368 phosphorylation of the Sphingosine 1-Phosphate Receptor 4
pS364/pS366/pS368-S1P4 (phospho-Sphingosine...
Serine364/Serine366/Serine368 (S364/S366/S368) is major phosphorylation site of the Sphingosine 1-Phosphate Receptor 4 (S1P4). The pS364/pS366/pS368-S1P4 antibody detects phosphorylation in response to agonists. S364/S366/S368...
$ 350.00 *
NEW
Agonist-induced Serine345 phosphorylation of the Sphingosine 1-Phosphate Receptor 5
pS345-S1P5 (phospho-Sphingosine 1-Phosphate...
Serine345 (S345) is major phosphorylation site of the Sphingosine 1-Phosphate Receptor 5 (S1P5). The pS345-S1P5 antibody detects phosphorylation in response to agonists. S345 phosphorylation is likely to be involved in efficient ligand...
$ 350.00 *
NEW
Agonist-induced Serine359/Serine361/Serine363 phosphorylation of the Sphingosine 1-Phosphate Receptor 5
pS359/pS361/pS363-S1P5 (phospho-Sphingosine...
Serine359/Serine361/Serine363 (S359/S361/S363) is major phosphorylation site of the Sphingosine 1-Phosphate Receptor 5 (S1P5). The pS359/pS361/pS363-S1P5 antibody detects phosphorylation in response to agonists. S359/S361/S363...
$ 350.00 *
NEW
Agonist-induced Serine366/Serine367 phosphorylation of the Sphingosine 1-Phosphate Receptor 5
pS366/pS367-S1P5 (phospho-Sphingosine...
Serine366/Ser367 (S366/S367) is major phosphorylation site of the Sphingosine 1-Phosphate Receptor 5 (S1P5). The pS366/pS367-S1P5 antibody detects phosphorylation in response to agonists. S366/S367 phosphorylation is likely to be...
$ 350.00 *
NEW
Validation of the Sphingosine 1-Phosphate Receptor 3 in transfected HEK293 cells.
S1P3 (non-phospho), Sphingosine 1-Phosphate...
The non-phospho-sphingosin 1-phosphate receptor 3 antibody is directed against the distal end of the carboxyl-terminal tail of human S1P3.
$ 350.00 *

For more information on somatostatin receptor pharmacology please refer to IUPHAR database. For further reading refer to:

Chun J, Hla T, Lynch KR, Spiegel S, Moolenaar WH. International Union of Basic and Clinical Pharmacology. LXXVIII. Lysophospholipid receptor nomenclature. Pharmacol Rev. 2010 Dec;62(4):579-87. doi: 10.1124/pr.110.003111. PMID: 21079037; PMCID: PMC2993255.

Kihara Y, Maceyka M, Spiegel S, Chun J. Lysophospholipid receptor nomenclature review: IUPHAR Review 8. Br J Pharmacol. 2014 Aug;171(15):3575-94. doi: 10.1111/bph.12678. Epub 2014 Jul 12. PMID: 24602016; PMCID: PMC4128058.

Blaho V, Chun J, Herr D, Jones D, Jonnalagadda D, Kihara Y. Lysophospholipid (S1P) receptors in GtoPdb v.2023.1. IUPHAR/BPS Guide to Pharmacology CITE. 2023; 2023(1).

For more information on somatostatin receptor pharmacology please refer to IUPHAR database. For further reading refer to: Chun J, Hla T, Lynch KR, Spiegel S, Moolenaar WH. International Union... read more »
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Sphingosine 1-Phosphate Receptor Antibodies

For more information on somatostatin receptor pharmacology please refer to IUPHAR database. For further reading refer to:

Chun J, Hla T, Lynch KR, Spiegel S, Moolenaar WH. International Union of Basic and Clinical Pharmacology. LXXVIII. Lysophospholipid receptor nomenclature. Pharmacol Rev. 2010 Dec;62(4):579-87. doi: 10.1124/pr.110.003111. PMID: 21079037; PMCID: PMC2993255.

Kihara Y, Maceyka M, Spiegel S, Chun J. Lysophospholipid receptor nomenclature review: IUPHAR Review 8. Br J Pharmacol. 2014 Aug;171(15):3575-94. doi: 10.1111/bph.12678. Epub 2014 Jul 12. PMID: 24602016; PMCID: PMC4128058.

Blaho V, Chun J, Herr D, Jones D, Jonnalagadda D, Kihara Y. Lysophospholipid (S1P) receptors in GtoPdb v.2023.1. IUPHAR/BPS Guide to Pharmacology CITE. 2023; 2023(1).

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