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TRH Receptor Phosphorylation Assays

Thyrotropin-releasing hormone (TRH) receptors are activated by the endogenous tripeptide TRH, pyroGlu-His-Proamide, that is synthesized in the hypothalamus and released into the hypothalamic-pituitary portal circulation to act on the pituitary. TRH is produced in many other tissues, especially within the nervous system, where it appears to act as a neurotransmitter/neuromodulator. TRH and TRH analogues fail to distinguish TRH1 and TRH2 receptors. TRH1 was cloned from a mouse pituitary tumor cDNA library in 1990. The second subtype of the TRH receptor (TRH2) was identified later in rat and mouse and several other species but has not been found in humans.

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OD signals in pS360-TRH1 Phosphorylation Assay
pS360-TRH1 Phosphorylation Assay Kit
The pS360-TRH1 Phosphorylation Assay Kit allows determination of TRH1 Phosphorylation in 96-well plates without the need for Western blot analysis.
$ 600.00 *
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OD signals in pS364/pT365-TRH1 Phosphorylation Assay
pS364/pT365-TRH1 Phosphorylation Assay Kit
The pS364/pT365-TRH1 Phosphorylation Assay Kit allows determination of TRH1 Phosphorylation in 96-well plates without the need for Western blot analysis.
$ 600.00 *
Details

For more information on TRH1 pharmacology please refer to the IUPHAR database. For further reading refer to:

Davenport AP, Gershengorn M, Hills R. Thyrotropin-releasing hormone receptors (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database. IUPHAR/BPS Guide to Pharmacology CITE. 2019; 2019(4). Available from: https://doi.org/10.2218/gtopdb/F63/2019.4.

Alexander SP, Christopoulos A, Davenport AP, Kelly E, Mathie A, Peters JA, Veale EL et al. (2021) THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: G protein-coupled receptors. Br J Pharmacol. 176 Suppl 1:S27-S156.

For more information on TRH1 pharmacology please refer to the IUPHAR database. For further reading refer to: Davenport AP, Gershengorn M, Hills R. Thyrotropin-releasing hormone receptors... read more »
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TRH Receptor Phosphorylation Assays

For more information on TRH1 pharmacology please refer to the IUPHAR database. For further reading refer to:

Davenport AP, Gershengorn M, Hills R. Thyrotropin-releasing hormone receptors (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database. IUPHAR/BPS Guide to Pharmacology CITE. 2019; 2019(4). Available from: https://doi.org/10.2218/gtopdb/F63/2019.4.

Alexander SP, Christopoulos A, Davenport AP, Kelly E, Mathie A, Peters JA, Veale EL et al. (2021) THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: G protein-coupled receptors. Br J Pharmacol. 176 Suppl 1:S27-S156.

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