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Chemerin Receptor 1 Phosphorylation Assays

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pS345/pS346-CMKLR1 Phosphorylation Assay Kit
pS345/pS346-CMKLR1 Phosphorylation Assay Kit
The pS345/pS346-CMKLR1 Phosphorylation Assay Kit allows determination of CMKLR1 Phosphorylation in 96-well plates without the need for Western blot analysis.
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Chemerin1 receptor (CMKLR1) was the first member of the chemerin family. It is activated by the chemoattractant protein and adipokine, chemerin. Chemerin1 receptor also responds to the lipid-derived, anti-inflammatory ligand resolvin E1 (RvE1). The Chemerin1 receptor is regulated by phosphorylation of carboxyl-terminal serine345/serine346 (pS345/pS346-CMKLR1), serine352/threonine354 (pS352/pT352-CMKLR1) and serine357/serine358 (pS357/pS358-CMKLR1). This nomenclature refers to the human CMKLR1. This phosphorylation motif is highly conserved across species and nearly identical in mice. Rats and humans. For more information on CMKLR1 pharmacology please refer to the IUPHAR database. For further reading refer to:

Kennedy AJ, Davenport AP. International Union of Basic and Clinical Pharmacology CIII: Chemerin Receptors CMKLR1 (Chemerin1) and GPR1 (Chemerin2) Nomenclature, Pharmacology, and Function. Pharmacol Rev. 2018 Jan;70(1):174-196. doi: 10.1124/pr.116.013177. Epub 2017 Dec 26. PMID: 29279348

Davenport AP, Monaghan AE. Chemerin receptors (version 2019.3) in the IUPHAR/BPS Guide to Pharmacology Database. IUPHAR/BPS Guide to Pharmacology CITE. 2019; 2019(3). Available from: https://doi.org/10.2218/gtopdb/F338/2021.3.

  Chemerin1 receptor (CMKLR1) was the first member of the chemerin family. It is activated by the chemoattractant protein and adipokine, chemerin. Chemerin1 receptor also responds to the... read more »
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Chemerin Receptor 1 Phosphorylation Assays

 

Chemerin1 receptor (CMKLR1) was the first member of the chemerin family. It is activated by the chemoattractant protein and adipokine, chemerin. Chemerin1 receptor also responds to the lipid-derived, anti-inflammatory ligand resolvin E1 (RvE1). The Chemerin1 receptor is regulated by phosphorylation of carboxyl-terminal serine345/serine346 (pS345/pS346-CMKLR1), serine352/threonine354 (pS352/pT352-CMKLR1) and serine357/serine358 (pS357/pS358-CMKLR1). This nomenclature refers to the human CMKLR1. This phosphorylation motif is highly conserved across species and nearly identical in mice. Rats and humans. For more information on CMKLR1 pharmacology please refer to the IUPHAR database. For further reading refer to:

Kennedy AJ, Davenport AP. International Union of Basic and Clinical Pharmacology CIII: Chemerin Receptors CMKLR1 (Chemerin1) and GPR1 (Chemerin2) Nomenclature, Pharmacology, and Function. Pharmacol Rev. 2018 Jan;70(1):174-196. doi: 10.1124/pr.116.013177. Epub 2017 Dec 26. PMID: 29279348

Davenport AP, Monaghan AE. Chemerin receptors (version 2019.3) in the IUPHAR/BPS Guide to Pharmacology Database. IUPHAR/BPS Guide to Pharmacology CITE. 2019; 2019(3). Available from: https://doi.org/10.2218/gtopdb/F338/2021.3.

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