Tachykinin 2/Neurokinin B (NK2) Receptor Antibodies

Tachykinin 2 (NK2) receptor is a member of the tachykinin receptor family, which preferentially binds its ligand neurokinin A (NKA, previously known as substance K). NK2 receptor is characterized by the ability to bind tachykinin neuropeptides resulting in rapid movement or “spasmodic contractions” of various tissue types. It is a seven transmembrane receptor that associates with the G-proteins Gs and Gq/G11. NK2 receptor is widely expressed in the smooth muscle of the gastrointestinal, respiratory, and urinary tracts and to a much lesser extent in some discrete regions of the CNS. NK2 receptors mediate smooth muscle contraction and relaxation, vasodilation, and activation of the immune system. Additionally, NK2 receptor plays notable roles in visceral pain sensitivity and modulating intestinal motility. NK2 receptor desensitization, β-arrestin recruitment and internalization are regulated by phosphorylation of carboxyl-terminal threonine339/threonine341 (pT339/pS341-NK2), serine345/threonine346 (pS345/pT346-NK2) and threonine353/threonine356 (pT353/pT356-NK2). This nomenclature refers to the human NK2 receptor. This phosphorylation motif is similar in mice and rats. For more information on NK2 pharmacology please refer to the IUPHAR database. For further reading refer to:

Barrett J, Canning B, Coulson J, Dombrowsky E, Douglas SD, Fong TM, Heyward CY, Leeman SE, Remeshwar P. Tachykinin receptors (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database. IUPHAR/BPS Guide to Pharmacology CITE. 2019; 2019(4).