Adrenoceptor Antibodies

Adrenoceptors are 7TM receptors which mediate the central and peripheral actions of the neurotransmitter, noradrenaline (norepinephrine), and the hormone and neurotransmitter, adrenaline (epinephrine). Adrenoceptors are found in nearly all peripheral tissues and on many neuronal populations within the central nervous system. Both noradrenaline and adrenaline play important roles in the control of blood pressure, myocardial contractile rate and force, airway reactivity, and a variety of metabolic and central nervous system functions.

Agonists and antagonists interacting with adrenoceptors have proved useful in the treatment of a variety of diseases, including hypertension, angina pectoris, congestive heart failure, asthma, depression, benign prostatic hypertrophy, and glaucoma.

Initially, α and β types were subdivided into α1, α2, β1 and β2 subtypes. Based on both pharmacological and molecular evidence, it is now clear that a more useful classification scheme is based on three major types - α1, α2 and β - each of which is further divided into at least three subtypes.

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Agonist-induced Serine355/Serine356 phosphorylation of the β2 Adrenoceptor

pS355/pS356-β2 (phospho-β2-Adrenoceptor Antibody)

Serine355/Serine356 (S355/S356) is a major phosphorylation site of the β2 adrenoceptor. The pS355/pS356-β2 antibody detects phosphorylation in response to high- and low-efficacy agonists but not after PKC activation. S355/S356...

$ 375.00 *

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NEW

Agonist-induced Threonine360/Serine364 phosphorylation of the β2 Adrenoceptor

pT360/pS364-β2 (phospho-β2-Adrenoceptor Antibody)

Threonine360/Serine364 (T360/S364) is a major phosphorylation site of the β2 adrenoceptor. The pT360/pS364-β2 antibody detects phosphorylation in response to high- and low-efficacy agonists but not after PKC activation. T360/S364...

$ 375.00 *

Details

NEW

Agonist-induced Serine355 phosphorylation of the β2-Adrenoceptor

pS355-β2 (phospho-β2-Adrenoceptor Antibody)

Serine355 (S355) is a major phosphorylation site of the β2 adrenoceptor. The pS355-β2 antibody detects phosphorylation in response to high- and low-efficacy agonists but not after PKC activation. S355 phosphorylation is primarily...

$ 375.00 *

Details

NEW

Agonist-induced Serine356 phosphorylation of the β2-Adrenoceptor

pS356-β2 (phospho-β2-Adrenoceptor Antibody)

Serine356 (S356) is a major phosphorylation site of the β2 adrenoceptor. The pS356-β2 antibody detects phosphorylation in response to high- and low-efficacy agonists but not after PKC activation. S356 phosphorylation is primarily...

$ 375.00 *

Details

NEW

Agonist-induced Serine364 phosphorylation of the β2-Adrenoceptor

pS364-β2 (phospho-β2-Adrenoceptor Antibody)

Serine364 (S364) is a major phosphorylation site of the β2 adrenoceptor. The pS364-β2 antibody detects phosphorylation in response to high- and low-efficacy agonists but not after PKC activation. S364 phosphorylation is primarily...

$ 375.00 *

Details

NEW

Validation of the β2-Adrenoceptor in transfected HEK293 cells

β2 (non-phospho), β2-Adrenoceptor Antibody

The non-phospho- β2 antibody is directed against the third intracellular loop of human β2 . It can be used to detect total β2 receptors in Western blots independent of phosphorylation. The non-phospho- β2 antibody can also be used to...

$ 375.00 *

Details

NEW

Agonist-induced Threonine404 phosphorylation of the β1-Adrenoceptor

pT404-β1 (phospho-β1-Adrenoceptor Antibody)

Threonine404 (T404) is a major phosphorylation site of the β1 adrenoceptor. The pT404-β1 antibody detects phosphorylation in response to high- and low-efficacy agonists but not after PKC activation. T404 phosphorylation is primarily...

$ 375.00 *

Details

NEW

Agonist-induced Serine412 phosphorylation of the β1-Adrenoceptor

pS412-β1 (phospho-β1-Adrenoceptor Antibody)

Serine412 (S412) is a major phosphorylation site of the β1 adrenoceptor. The pS412-β1 antibody detects phosphorylation in response to high- and low-efficacy agonists but not after PKC activation. S412 phosphorylation is primarily...

$ 375.00 *

Details

NEW

Validation of the β1-Adrenoceptor in transfected HEK293 cells

β1 (non-phospho), β1-Adrenoceptor Antibody

The non-phospho- β1 antibody is directed against the carboxyl-terminal tail of human β1 . It can be used to detect total β1 receptors in Western blots independent of phosphorylation. The non-phospho- β1 antibody can also be used to...

$ 375.00 *

Details

NEW

Agonist-induced Serine261/Serine262 phosphorylation of the β2-Adrenoceptor

pS261pS262-β2 (phospho-β2-Adrenoceptor Antibody)

Serine261/Serine262 (S261/S262) is a major phosphorylation site of the β2 adrenoceptor. The pS261/pS262-β2 antibody detects phosphorylation in response to high- and low-efficacy agonists but not after PKC activation. S261/S262...

$ 375.00 *

Details

SAMPLE PACK

β2-Adrenoceptor Sample Pack (phospho- and...

β2-Adrenoceptor Antibody Sample Pack consisting of three phospho- and one non-phospho-β2-Adrenoceptor Antibodies 4 x 20 µL trial size each. Specifically, this sample pack contains the following antibodies pS355/pS356-β2 (7TM0029A),...

$ 300.00 *

Details

NEW

Agonist-induced Threonine360 phosphorylation of the β2-Adrenoceptor

pT360-β2 (phospho-β2-Adrenoceptor Antibody)

Threonine360 (T360) is a major phosphorylation site of the β2 adrenoceptor. The pT360-β2 antibody detects phosphorylation in response to high- and low-efficacy agonists but not after PKC activation. T360 phosphorylation is primarily...

$ 350.00 *

Details

For more information on adrenoceptor pharmacology please refer to the IUPHAR database. For further reading refer to:

Bylund DB, Eikenberg DC, Hieble JP, Langer SZ, Lefkowitz RJ, Minneman KP, Molinoff PB, Ruffolo RR Jr, Trendelenburg U. International Union of Pharmacology nomenclature of adrenoceptors. Pharmacol Rev. 1994 Jun;46(2):121-36. PMID: 7938162.

Hieble JP, Bylund DB, Clarke DE, Eikenburg DC, Langer SZ, Lefkowitz RJ, Minneman KP, Ruffolo RR Jr. International Union of Pharmacology. X. Recommendation for nomenclature of alpha 1-adrenoceptors: consensus update. Pharmacol Rev. 1995 Jun;47(2):267-70. PMID: 7568329.

Baker JG, Hill SJ, Summers RJ. Evolution of β-blockers: from anti-anginal drugs to ligand-directed signalling. Trends Pharmacol Sci. 2011 Apr;32(4):227-34. doi: 10.1016/j.tips.2011.02.010. Epub 2011 Mar 21. PMID: 21429598; PMCID: PMC3081074.

Kobilka BK. Structural insights into adrenergic receptor function and pharmacology. Trends Pharmacol Sci. 2011 Apr;32(4):213-8. doi: 10.1016/j.tips.2011.02.005. Epub 2011 Mar 15. PMID: 21414670; PMCID: PMC3090711.

Langer SZ. α2-Adrenoceptors in the treatment of major neuropsychiatric disorders. Trends Pharmacol Sci. 2015 Apr;36(4):196-202. doi: 10.1016/j.tips.2015.02.006. Epub 2015 Mar 13. PMID: 25771972.

Benkel T, Zimmermann M, Zeiner J, Bravo S, Merten N, Lim VJY, Matthees ESF, Drube J, Miess-Tanneberg E, Malan D, Szpakowska M, Monteleone S, Grimes J, Koszegi Z, Lanoiselée Y, O'Brien S, Pavlaki N, Dobberstein N, Inoue A, Nikolaev V, Calebiro D, Chevigné A, Sasse P, Schulz S, Hoffmann C, Kolb P, Waldhoer M, Simon K, Gomeza J, Kostenis E. How Carvedilol activates β2-adrenoceptors. Nat Commun. 2022 Nov 19;13(1):7109. doi: 10.1038/s41467-022-34765-w. PMID: 36402762; PMCID: PMC9675828.

For more information on adrenoceptor pharmacology please refer to the IUPHAR database. For further reading refer to: Bylund DB, Eikenberg DC, Hieble JP, Langer SZ, Lefkowitz RJ, Minneman KP,... read more »

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Adrenoceptor Antibodies

For more information on adrenoceptor pharmacology please refer to the IUPHAR database. For further reading refer to:

Langer SZ. α2-Adrenoceptors in the treatment of major neuropsychiatric disorders. Trends Pharmacol Sci. 2015 Apr;36(4):196-202. doi: 10.1016/j.tips.2015.02.006. Epub 2015 Mar 13. PMID: 25771972.