EP2 Receptor Antibodies
EP2 receptors preferentially couple through Gs protein to stimulate adenylate cyclase. EP2 receptors may be present on smooth muscle cells with high sensitivity to PGE2. Selective agonists based on the PGE2 structure exist and agonists with a non-prostanoid structure exist for EP2 receptors. Recently selective and potent EP2 receptor antagonists have emerged. EP2 receptors are regulated by phosphorylation of carboxyl-terminal threonine342/threonine344 (pT342/pT344-EP2), threonine344/serine345 (pT344/pS345-EP2) and serine347/threonine348 (pS347/pT348-EP2). This nomenclature refers to the human EP2 receptor. This phosphorylation motif is conserved across species but corresponds to pT344/pS345-EP2 and pS347/pT348-EP2 in mice and to pS345-EP2 and pS347/pT348-EP2 in rats. For more information on prostanoid receptor pharmacology please refer to the IUPHAR database. For further reading refer to:
Coleman RA, Smith WL, Narumiya S. International Union of Pharmacology classification of prostanoid receptors: properties, distribution, and structure of the receptors and their subtypes. Pharmacol Rev. 1994 Jun;46(2):205-29. PMID: 7938166.
Woodward DF, Jones RL, Narumiya S. International Union of Basic and Clinical Pharmacology. LXXXIII: classification of prostanoid receptors, updating 15 years of progress. Pharmacol Rev. 2011 Sep;63(3):471-538. doi: 10.1124/pr.110.003517. PMID: 21752876.