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Somatostatin Receptor Antibodies

Somatostatin receptors are activated by somatotropin-release inhibiting factor (SRIF) that exerts potent inhibitory actions on hormone secretion and neuronal excitability. The somatostatin receptor family consists of five members designated somatostatin receptors 1-5 (SST1-SST5). SST2 is the pharmacological target for octreotide (Sandostatin) which is the first line medical treatment for growth hormone (GH)-producing adenomas (acromegaly) and gastrointestinal neuroendocrine tumors (NET). SST5 is the primary pharmacological target for pasireotide (Signifor) which is the first line medical treatment for adrenocorticotropic hormone (ACTH)-producing adenomas (Cushing’s disease). In addition, SST2 is a prototypical GPCR for the development of peptide-based radiopharmaceuticals for diagnostic and therapeutic interventions of human tumors.

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OD signals in pS341/pS343-SST2 Phosphorylation Assay
pS341/pS343-SST2 Phosphorylation Assay Kit
The pS341/pS343-SST2 Phosphorylation Assay Kit allows determination of SST2 Phosphorylation in 96-well plates without the need for Western blot analysis.
$ 300.00 $ 600.00 *
50
NEW
OD signals in pT356/pT359-SST2 Phosphorylation Assay
pT356/pT359-SST2 Phosphorylation Assay Kit
The pT356/pT359-SST2 Phosphorylation Assay Kit allows determination of SST2 Phosphorylation in 96-well plates without the need for Western blot analysis.
$ 300.00 $ 600.00 *

For more information on somatostatin receptor pharmacology please refer to IUPHAR database. For further reading refer to:

Günther T, Tulipano G, Dournaud P, Bousquet C, Csaba Z, Kreienkamp HJ, Lupp A, Korbonits M, Castaño JP, Wester HJ, Culler M, Melmed S, Schulz S. International Union of Basic and Clinical Pharmacology. CV. Somatostatin Receptors: Structure, Function, Ligands, and New Nomenclature. Pharmacol Rev. 2018 Oct;70(4):763-835. doi: 10.1124/pr.117.015388. Review. PubMed PMID: 30232095; PubMed Central PMCID: PMC6148080.

For more information on somatostatin receptor pharmacology please refer to IUPHAR database. For further reading refer to: Günther T, Tulipano G, Dournaud P, Bousquet C, Csaba Z, Kreienkamp... read more »
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Somatostatin Receptor Antibodies

For more information on somatostatin receptor pharmacology please refer to IUPHAR database. For further reading refer to:

Günther T, Tulipano G, Dournaud P, Bousquet C, Csaba Z, Kreienkamp HJ, Lupp A, Korbonits M, Castaño JP, Wester HJ, Culler M, Melmed S, Schulz S. International Union of Basic and Clinical Pharmacology. CV. Somatostatin Receptors: Structure, Function, Ligands, and New Nomenclature. Pharmacol Rev. 2018 Oct;70(4):763-835. doi: 10.1124/pr.117.015388. Review. PubMed PMID: 30232095; PubMed Central PMCID: PMC6148080.

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