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Nociceptin/Orphanin FQ Receptor Antibodies

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KO-Validated
Validation of the Nociceptin/Orphanin FQ Receptor in transfected HEK293 cells.
NOP (non-phospho), Nociceptin/Orphanin FQ...
The non-phospho-NFQ receptor (NOP) antibody is directed against the distal end of the carboxyl-terminal tail of mouse, rat and human NOP. It can be used to detect total NOP receptors in Western blots independent of phosphorylation. The...
$ 375.00 *
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Agonist-induced Serine346 phosphorylation of the Nociceptin/Orphanin FQ Receptor.
pS346-NOP (phospho-Nociceptin/Orphanin FQ...
Serine346 (S346) is a major phosphorylation site of the nociceptin/orphanin FQ peptide receptor (NFQ receptor, NOP). The pS346-NOP antibody detects phosphorylation in response to agonists as well as after PKC activation. S346...
$ 375.00 *
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Agonist-induced Serine351 phosphorylation of the Nociceptin/Orphanin FQ Receptor.
pS351-NOP (phospho-Nociceptin/Orphanin FQ...
Serine351 (S351) is a major phosphorylation site of the nociceptin/orphanin FQ peptide receptor (NFQ receptor, NOP). The pS351-NOP antibody detects phosphorylation in response to agonists as well as after PKC activation. S351...
$ 375.00 *
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Citations
Agonist-induced Threonine362/Serine363 phosphorylation of the Nociceptin/Orphanin FQ Receptor.
pT362/pS363-NOP (phospho-Nociceptin/Orphanin FQ...
Threonine362/Serine363 (T362/S363) is a major phosphorylation site of the nociceptin/orphanin FQ peptide receptor (NFQ receptor, NOP). The pT362/pS363-NOP antibody detects phosphorylation in response to agonists but not after PKC...
$ 375.00 *
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NOPgDAKoGzAvFpzY

The nociceptin/orphanin FQ receptor (NFQ receptor, NOP) is the fourth discovered member of the opioid receptor family. Bifunctional agonists that target NOP and MOP such as cebranopadol or AT-121 are under active investigation as novel analgesics with fewer side effects. NOP desensitization, trafficking and signaling are regulated by phosphorylation of carboxyl-terminal serine346 (pS346-NOP), serine351 (pS351-NOP) and threonine362/serine363 (pT362/pS363-NOP) residues. Agonist-induced NOP phosphorylation is predominantly mediated by GRK2 and GRK3. S346 and S351 are also substrates for PKC-mediated phosphorylation. The nomenclature refers to the human NOP. This phosphorylation motif is also present in mice and rats. For more information on NFQ receptor pharmacology please refer to the IUPHAR database. For further reading refer to:

Mann A, Moulédous L, Froment C, O'Neill PR, Dasgupta P, Günther T, Brunori G, Kieffer BL, Toll L, Bruchas MR, Zaveri NT, Schulz S. Agonist-selective NOP receptor phosphorylation correlates in vitro and in vivo and reveals differential post-activation signaling by chemically diverse agonists. Sci Signal. 2019 Mar 26;12(574). pii: eaau8072. doi: 10.1126/scisignal.aau8072. PubMed PMID: 30914485; PubMed Central PMCID: PMC6934085.

Dasgupta P, Mann A, Polgar WE, Reinscheid RK, Zaveri NT, Schulz S. Attenuated G protein signaling and minimal receptor phosphorylation as a biochemical signature of low side-effect opioid analgesics. Sci Rep. 2022 May 3;12(1):7154. doi: 10.1038/s41598-022-11189-6. PMID: 35504962; PMCID: PMC9065038.

Toll L, Bruchas MR, Calo' G, Cox BM, Zaveri NT. Nociceptin/Orphanin FQ Receptor Structure, Signaling, Ligands, Functions, and Interactions with Opioid Systems. Pharmacol Rev. 2016 Apr;68(2):419-57. doi: 10.1124/pr.114.009209. Epub 2016 Mar 8. Review. PubMed PMID: 26956246; PubMed Central PMCID: PMC4813427.

The nociceptin/orphanin FQ receptor (NFQ receptor, NOP) is the fourth discovered member of the opioid receptor family. Bifunctional agonists that target NOP and MOP such as cebranopadol or... read more »
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Nociceptin/Orphanin FQ Receptor Antibodies

NOPgDAKoGzAvFpzY

The nociceptin/orphanin FQ receptor (NFQ receptor, NOP) is the fourth discovered member of the opioid receptor family. Bifunctional agonists that target NOP and MOP such as cebranopadol or AT-121 are under active investigation as novel analgesics with fewer side effects. NOP desensitization, trafficking and signaling are regulated by phosphorylation of carboxyl-terminal serine346 (pS346-NOP), serine351 (pS351-NOP) and threonine362/serine363 (pT362/pS363-NOP) residues. Agonist-induced NOP phosphorylation is predominantly mediated by GRK2 and GRK3. S346 and S351 are also substrates for PKC-mediated phosphorylation. The nomenclature refers to the human NOP. This phosphorylation motif is also present in mice and rats. For more information on NFQ receptor pharmacology please refer to the IUPHAR database. For further reading refer to:

Mann A, Moulédous L, Froment C, O'Neill PR, Dasgupta P, Günther T, Brunori G, Kieffer BL, Toll L, Bruchas MR, Zaveri NT, Schulz S. Agonist-selective NOP receptor phosphorylation correlates in vitro and in vivo and reveals differential post-activation signaling by chemically diverse agonists. Sci Signal. 2019 Mar 26;12(574). pii: eaau8072. doi: 10.1126/scisignal.aau8072. PubMed PMID: 30914485; PubMed Central PMCID: PMC6934085.

Dasgupta P, Mann A, Polgar WE, Reinscheid RK, Zaveri NT, Schulz S. Attenuated G protein signaling and minimal receptor phosphorylation as a biochemical signature of low side-effect opioid analgesics. Sci Rep. 2022 May 3;12(1):7154. doi: 10.1038/s41598-022-11189-6. PMID: 35504962; PMCID: PMC9065038.

Toll L, Bruchas MR, Calo' G, Cox BM, Zaveri NT. Nociceptin/Orphanin FQ Receptor Structure, Signaling, Ligands, Functions, and Interactions with Opioid Systems. Pharmacol Rev. 2016 Apr;68(2):419-57. doi: 10.1124/pr.114.009209. Epub 2016 Mar 8. Review. PubMed PMID: 26956246; PubMed Central PMCID: PMC4813427.

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