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Endothelin Receptor B Antibodies

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Agonist-induced Serine435/Serine436 phosphorylation of the Endothelin Receptor B
pS435/pS436-ETB (phospho-Endothelin Receptor B...
Serine435/Serine436 (S435/S436) is major phosphorylation site of the Endothelin Receptor B (ETB). The pS435/pS436-ETB antibody detects phosphorylation in response to agonists. S435/S436 phosphorylation is likely to be involved in...
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Validation of the Endothelin Receptor B in transfected HEK293 cells.
ETB (non-phospho-Endothelin Receptor B Antibody)
The non-phospho-ETB receptor antibody is directed against the distal part of the carboxyl-terminal tail of human Endothelin Receptor B (ETB). It can be used to detect total ETB receptors in Western blots independent of phosphorylation....
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ETB receptors couple to Gq and Gi. Coupling to Gs occurs through the second and third intracellular loops of the receptor. In order to couple with Gi through the third intracellular loop, palmitoylation of the C-terminal cysteine residues is important. BQ788 (peptides) and Ro 46-8443 (non-peptide) are selective ETB receptor antagonists. ETB activity is regulated by phosphorylation of carboxyl-terminal serine435/serine436 (pS435/pS436-ETB). This nomenclature refers to the human ETB receptor. This phosphorylation motif is highly conserved and is identical in mice, rats and humans. For more information on ETB pharmacology please refer to the IUPHAR database. For further reading refer to:

Barton M, Yanagisawa M. Endothelin: 30 Years From Discovery to Therapy. Hypertension. 2019 Dec;74(6):1232-1265. doi: 10.1161/HYPERTENSIONAHA.119.12105.Epub 2019 Nov 4. PMID: 31679425.

Davenport AP, Hyndman KA, Dhaun N, Southan C, Kohan DE, Pollock JS, Pollock DM, Webb DJ, Maguire JJ. Endothelin. Pharmacol Rev. 2016 Apr;68(2):357-418. doi: 10.1124/pr.115.011833. PMID: 26956245; PMCID: PMC4815360.

Davenport AP, D'Orléans-Juste P, Godfraind T, Maguire JJ, Ohlstein EH, Ruffolo RR. Endothelin receptors (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database. IUPHAR/BPS Guide to Pharmacology CITE. 2019; 2019(4).

ETB receptors couple to Gq and Gi. Coupling to Gs occurs through the second and third intracellular loops of the receptor. In order to couple with Gi through the third intracellular loop,... read more »
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Endothelin Receptor B Antibodies

ETB receptors couple to Gq and Gi. Coupling to Gs occurs through the second and third intracellular loops of the receptor. In order to couple with Gi through the third intracellular loop, palmitoylation of the C-terminal cysteine residues is important. BQ788 (peptides) and Ro 46-8443 (non-peptide) are selective ETB receptor antagonists. ETB activity is regulated by phosphorylation of carboxyl-terminal serine435/serine436 (pS435/pS436-ETB). This nomenclature refers to the human ETB receptor. This phosphorylation motif is highly conserved and is identical in mice, rats and humans. For more information on ETB pharmacology please refer to the IUPHAR database. For further reading refer to:

Barton M, Yanagisawa M. Endothelin: 30 Years From Discovery to Therapy. Hypertension. 2019 Dec;74(6):1232-1265. doi: 10.1161/HYPERTENSIONAHA.119.12105.Epub 2019 Nov 4. PMID: 31679425.

Davenport AP, Hyndman KA, Dhaun N, Southan C, Kohan DE, Pollock JS, Pollock DM, Webb DJ, Maguire JJ. Endothelin. Pharmacol Rev. 2016 Apr;68(2):357-418. doi: 10.1124/pr.115.011833. PMID: 26956245; PMCID: PMC4815360.

Davenport AP, D'Orléans-Juste P, Godfraind T, Maguire JJ, Ohlstein EH, Ruffolo RR. Endothelin receptors (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database. IUPHAR/BPS Guide to Pharmacology CITE. 2019; 2019(4).

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