Premium Phosphosite-Specific 7TM Antibodies
Novel Tools for Your GPCR Research
Select Your Country of Delivery below

Prostanoid Receptor Phosphorylation Assays

Prostanoid receptors are activated by the endogenous ligands prostaglandins PGD2, PGE1, PGE2 , PGF2α, PGH2, prostacyclin (PGI2) and thromboxane A2. Cyclo-oxygenase (COX) converts arachidonic acid to prostaglandin H2 (PGH2), from which further prostanoids, PGD2, PGE2, PGF2α, PGI2 (prostacyclin) and thromboxane A2 (TXA2) are enzymatically derived. Based on the agonist potencies of the latter prostanoids (and the limited use of receptor antagonists), five prostanoid receptors were recognized and correspondingly named DP, EP, FP, IP and TP receptors. Additionally, EP receptors have been subdivided into four groups, termed EP1, EP2, EP3 and EP4. cDNA cloning identified a family of eight G-protein coupled receptors (GPCRs) that correspond to these pharmacologically-defined receptors. cDNA cloning also revealed the presence of an additional GPCR called CRTH2 that mediates some PGD2 actions. Therefore, the DP receptor now has two subtypes, DP1 and DP2 (CRTH2).

Close filters
No results were found for the filter!
NEW
pT372/pS373-EP3 Phosphorylation Assay Kit
pT372/pS373-EP3 Phosphorylation Assay Kit
The pS351/pS353-S1P1 Phosphorylation Assay Kit allows determination of S1P1 Phosphorylation in 96-well plates without the need for Western blot analysis.
$ 600.00 *

For more information on prostanoid receptor pharmacology please refer to the IUPHAR database. For further reading refer to:

Coleman RA, Smith WL, Narumiya S. International Union of Pharmacology classification of prostanoid receptors: properties, distribution, and structure of the receptors and their subtypes. Pharmacol Rev. 1994 Jun;46(2):205-29. PMID: 7938166.

Woodward DF, Jones RL, Narumiya S. International Union of Basic and Clinical Pharmacology. LXXXIII: classification of prostanoid receptors, updating 15 years of progress. Pharmacol Rev. 2011 Sep;63(3):471-538. doi: 10.1124/pr.110.003517. PMID: 21752876.

For more information on prostanoid receptor pharmacology please refer to the  IUPHAR  database. For further reading refer to: Coleman RA, Smith WL, Narumiya S. International Union of... read more »
Close window
Prostanoid Receptor Phosphorylation Assays

For more information on prostanoid receptor pharmacology please refer to the IUPHAR database. For further reading refer to:

Coleman RA, Smith WL, Narumiya S. International Union of Pharmacology classification of prostanoid receptors: properties, distribution, and structure of the receptors and their subtypes. Pharmacol Rev. 1994 Jun;46(2):205-29. PMID: 7938166.

Woodward DF, Jones RL, Narumiya S. International Union of Basic and Clinical Pharmacology. LXXXIII: classification of prostanoid receptors, updating 15 years of progress. Pharmacol Rev. 2011 Sep;63(3):471-538. doi: 10.1124/pr.110.003517. PMID: 21752876.

Recently viewed