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Immuno-Grade S1P1 Receptor Antibodies

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Immunohistochemical identification of S1P1 Receptor in human spleen
S1P1 (IHC-grade), Sphingosine 1-Phosphate...
The non-phospho-S1P1 receptor antibody is directed against the distal end of the carboxyl-terminal tail of human S1P1. It also detects S1P1 in cultured cells and tissue sections by immunohistochemistry. It can be used to detect total...
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The S1P1 receptor is expressed throughout all mammalian organ systems. S1P1 receptor activation down-regulates allergic inflammation. In human cord blood mast cells, S1P1 is required for migration but not for degranulation or cytokine and chemokine release. S1P1 expression is elevated by allergen challenge in allergic rhinitis patients, but not in corticosteroid treated patients. Functionally, S1P1 receptors are able to couple to the pertusiss toxin-sensitive Gi/o-proteins. Signaling is required for normal chemotaxis toward sphingosine 1-phosphate. S1P1 is required for normal embryonic heart development and normal cardiac morphogenesis. It also plays an important role in the regulation of sprouting angiogenesis and vascular maturation. S1P1 receptor desensitization, β-arrestin recruitment and internalization are regulated by phosphorylation of carboxyl-terminal serine351/threonine353/serine355 (pS351/pT353-S1P1) and (pS353/pT355-S1P1) and serine358/serine359 (pS358/pS359-S1P1). This nomenclature refers to the human S1P1 receptor. This phosphorylation motif is highly conserved across species and is identical mice, rats and humans. For more information on S1P1 pharmacology please refer to the IUPHAR database. For further reading refer to:

Chun J, Hla T, Lynch KR, Spiegel S, Moolenaar WH. International Union of Basic and Clinical Pharmacology. LXXVIII. Lysophospholipid receptor nomenclature. Pharmacol Rev. 2010 Dec;62(4):579-87. doi: 10.1124/pr.110.003111. PMID: 21079037; PMCID: PMC2993255.

Kihara Y, Maceyka M, Spiegel S, Chun J. Lysophospholipid receptor nomenclature review: IUPHAR Review 8. Br J Pharmacol. 2014 Aug;171(15):3575-94. doi: 10.1111/bph.12678. Epub 2014 Jul 12. PMID: 24602016; PMCID: PMC4128058.

Blaho V, Chun J, Herr D, Jones D, Jonnalagadda D, Kihara Y. Lysophospholipid (S1P) receptors in GtoPdb v.2023.1. IUPHAR/BPS Guide to Pharmacology CITE. 2023; 2023(1).

The S1P1 receptor is expressed throughout all mammalian organ systems. S1P1 receptor activation down-regulates allergic inflammation. In human cord blood mast cells, S1P1 is required for migration... read more »
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Immuno-Grade S1P1 Receptor Antibodies

The S1P1 receptor is expressed throughout all mammalian organ systems. S1P1 receptor activation down-regulates allergic inflammation. In human cord blood mast cells, S1P1 is required for migration but not for degranulation or cytokine and chemokine release. S1P1 expression is elevated by allergen challenge in allergic rhinitis patients, but not in corticosteroid treated patients. Functionally, S1P1 receptors are able to couple to the pertusiss toxin-sensitive Gi/o-proteins. Signaling is required for normal chemotaxis toward sphingosine 1-phosphate. S1P1 is required for normal embryonic heart development and normal cardiac morphogenesis. It also plays an important role in the regulation of sprouting angiogenesis and vascular maturation. S1P1 receptor desensitization, β-arrestin recruitment and internalization are regulated by phosphorylation of carboxyl-terminal serine351/threonine353/serine355 (pS351/pT353-S1P1) and (pS353/pT355-S1P1) and serine358/serine359 (pS358/pS359-S1P1). This nomenclature refers to the human S1P1 receptor. This phosphorylation motif is highly conserved across species and is identical mice, rats and humans. For more information on S1P1 pharmacology please refer to the IUPHAR database. For further reading refer to:

Chun J, Hla T, Lynch KR, Spiegel S, Moolenaar WH. International Union of Basic and Clinical Pharmacology. LXXVIII. Lysophospholipid receptor nomenclature. Pharmacol Rev. 2010 Dec;62(4):579-87. doi: 10.1124/pr.110.003111. PMID: 21079037; PMCID: PMC2993255.

Kihara Y, Maceyka M, Spiegel S, Chun J. Lysophospholipid receptor nomenclature review: IUPHAR Review 8. Br J Pharmacol. 2014 Aug;171(15):3575-94. doi: 10.1111/bph.12678. Epub 2014 Jul 12. PMID: 24602016; PMCID: PMC4128058.

Blaho V, Chun J, Herr D, Jones D, Jonnalagadda D, Kihara Y. Lysophospholipid (S1P) receptors in GtoPdb v.2023.1. IUPHAR/BPS Guide to Pharmacology CITE. 2023; 2023(1).

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