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Vasopressin/Oxytocin Receptor Antibodies

Vasopressin and oxytocin receptors are activated by the endogenous cyclic nonapeptides vasopressin (AVP) and oxytocin (OT). These peptides are derived from precursors which also produce neurophysins. Vasopressin and oxytocin differ at only 2 amino acids (positions 3 and 8). Four receptors exist in mammals, three for AVP and a unique receptor for OT, although AVP possesses a nanomolar affinity for all subtypes. AVP is also named the antidiuretic hormone (ADH) due to its effect on the regulation of water body balance whereas oxytocin is defined as the "quick birth" hormone because of its highly potent uterotonic activity. AVP has multiple physiological functions, including body water regulation, control of blood pressure, platelet aggregation, release of coagulation factors, cell proliferation, and effects on body temperature, insulin release, corticotropin release, memory and social behaviour. All these actions are mediated through activation of three specific membrane-bound receptors present at the surface of the target cells. On the basis of pharmacological and functional studies, these receptors have been classified as V1A, V1B and V2 subtypes. The neurohypophysial peptide oxytocin facilitates reproduction in all vertebrates at several levels via activation of the OT receptor.

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OD signals in pS362/pS363/pS364-V2 Phosphorylation Assay
pS362/pS363/pS364-V2 Phosphorylation Assay Kit
The pS362/pS363/pS364-V2 Phosphorylation Assay Kit allows determination of V2 Phosphorylation in 96-well plates without the need for Western blot analysis.
$ 300.00 $ 600.00 *
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NEW
OD signals in pT359/pT360-V2 Phosphorylation Assay
pT359/pT360-V2 Phosphorylation Assay Kit
The pT359/pT360-V2 Phosphorylation Assay Kit allows determination of V2 Phosphorylation in 96-well plates without the need for Western blot analysis.
$ 300.00 $ 600.00 *

For more information on vasopressin/oxytocin receptor pharmacology please refer to the IUPHAR database. For further reading refer to:

Carter CS, Kenkel WM, MacLean EL, Wilson SR, Perkeybile AM, Yee JR, Ferris CF, Nazarloo HP, Porges SW, Davis JM, Connelly JJ, Kingsbury MA. Is Oxytocin
"Nature's Medicine"? Pharmacol Rev. 2020 Oct;72(4):829-861. doi: 10.1124/pr.120.019398. PMID: 32912963; PMCID: PMC7495339.

Bichet D, Bouvier M, Chini B, Gimpl G, Guillon G, Kimura T, Knepper M, Lolait S, Manning M, Mouillac B, O'Carroll AM, Serradeil-Le Gal C, Soloff M, Verbalis JG, Wheatley M, Zingg HH. Vasopressin and oxytocin receptors (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database. IUPHAR/BPS Guide to Pharmacology CITE. 2019; 2019(4).

For more information on vasopressin/oxytocin receptor pharmacology please refer to the  IUPHAR  database. For further reading refer to: Carter CS, Kenkel WM, MacLean EL, Wilson SR,... read more »
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Vasopressin/Oxytocin Receptor Antibodies

For more information on vasopressin/oxytocin receptor pharmacology please refer to the IUPHAR database. For further reading refer to:

Carter CS, Kenkel WM, MacLean EL, Wilson SR, Perkeybile AM, Yee JR, Ferris CF, Nazarloo HP, Porges SW, Davis JM, Connelly JJ, Kingsbury MA. Is Oxytocin
"Nature's Medicine"? Pharmacol Rev. 2020 Oct;72(4):829-861. doi: 10.1124/pr.120.019398. PMID: 32912963; PMCID: PMC7495339.

Bichet D, Bouvier M, Chini B, Gimpl G, Guillon G, Kimura T, Knepper M, Lolait S, Manning M, Mouillac B, O'Carroll AM, Serradeil-Le Gal C, Soloff M, Verbalis JG, Wheatley M, Zingg HH. Vasopressin and oxytocin receptors (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database. IUPHAR/BPS Guide to Pharmacology CITE. 2019; 2019(4).

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