Immuno-Grade Neurotensin Receptor 2 Antibodies
The neurotensin receptor 2 (NTS2) is the specific receptor for neurotensin (NT). NTS2 can be distinguished from other NT receptors by levocabastine, a histamine H1 antagonist, which totally and selectively inhibits the binding of NT to NTS2. Cerebral administration of NT modulates dopaminergic transmission and leads to hypothermic and naloxone-independent analgesic responses. In the periphery, NT induces hypotension, decreases gastric acid secretion and activates lipid digestion. NTS2 receptors are highly abundant in parietal cells of the gastric mucosa, in neuroendocrine cells of the stomach, small and large intestine, and in cells of the exocrine pancreas.