A2A Adenosine Receptor Antibodies
A2A receptor on immune cells (e.g. T cells, NK cells, dendritic cells and macrophages) mediate the immunosuppressive effects of adenosine, an action that produces a powerful tolerogenic/immunosuppressed state. As a result, A2A has been suggested as an immune checkpoint that produces a negative feedback loop in the tumor microenvironment. The A2A receptor primarily couples to Gs proteins ti stimulate adenylyl cyclase. The A2A receptor is constitutively phosphorylated at serine329 (pS329-A2A). Agonist activation enhances S329 phosphorylation. For more information on A2A receptor pharmacology please refer to the IUPHAR database. For further reading refer to:
Fredholm BB, Abbracchio MP, Burnstock G, Daly JW, Harden TK, Jacobson KA, Leff P, Williams M. Nomenclature and classification of purinoceptors. Pharmacol Rev. 1994 Jun;46(2):143-56. PMID: 7938164; PMCID: PMC4976594.
Fredholm BB, Frenguelli BG, Hills R, IJzerman AP, Jacobson KA, Klotz KN, Linden J, Müller CE, Schwabe U, Stiles GL. Adenosine receptors in GtoPdb v.2021.2. IUPHAR/BPS Guide to Pharmacology CITE. 2021; 2021(2).