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A2A Adenosine Receptor Antibodies

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Agonist-induced Serine329 phosphorylation of the A2A Adenosine Receptor
pS329-A2A (phospho-A2A Adenosine Receptor...
Serine329 is a major phosphorylation site of the A2A Adenosine receptor. The pS329-A2A antibody detects phosphorylation in response to high-efficacy agonists but not after PKC activation. S329 phosphorylation is a key regulator of A2A...
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A2A receptor on immune cells (e.g. T cells, NK cells, dendritic cells and macrophages) mediate the immunosuppressive effects of adenosine, an action that produces a powerful tolerogenic/immunosuppressed state. As a result, A2A has been suggested as an immune checkpoint that produces a negative feedback loop in the tumor microenvironment. The A2A receptor primarily couples to Gs proteins ti stimulate adenylyl cyclase. The A2A receptor is constitutively phosphorylated at serine329 (pS329-A2A). Agonist activation enhances S329 phosphorylation. For more information on A2A receptor pharmacology please refer to the IUPHAR database. For further reading refer to:

Fredholm BB, Abbracchio MP, Burnstock G, Daly JW, Harden TK, Jacobson KA, Leff P, Williams M. Nomenclature and classification of purinoceptors. Pharmacol Rev. 1994 Jun;46(2):143-56. PMID: 7938164; PMCID: PMC4976594.

Fredholm BB, Frenguelli BG, Hills R, IJzerman AP, Jacobson KA, Klotz KN, Linden J, Müller CE, Schwabe U, Stiles GL. Adenosine receptors in GtoPdb v.2021.2. IUPHAR/BPS Guide to Pharmacology CITE. 2021; 2021(2).

A2A receptor on immune cells (e.g. T cells, NK cells, dendritic cells and macrophages) mediate the immunosuppressive effects of adenosine, an action that produces a powerful... read more »
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A2A Adenosine Receptor Antibodies

A2A receptor on immune cells (e.g. T cells, NK cells, dendritic cells and macrophages) mediate the immunosuppressive effects of adenosine, an action that produces a powerful tolerogenic/immunosuppressed state. As a result, A2A has been suggested as an immune checkpoint that produces a negative feedback loop in the tumor microenvironment. The A2A receptor primarily couples to Gs proteins ti stimulate adenylyl cyclase. The A2A receptor is constitutively phosphorylated at serine329 (pS329-A2A). Agonist activation enhances S329 phosphorylation. For more information on A2A receptor pharmacology please refer to the IUPHAR database. For further reading refer to:

Fredholm BB, Abbracchio MP, Burnstock G, Daly JW, Harden TK, Jacobson KA, Leff P, Williams M. Nomenclature and classification of purinoceptors. Pharmacol Rev. 1994 Jun;46(2):143-56. PMID: 7938164; PMCID: PMC4976594.

Fredholm BB, Frenguelli BG, Hills R, IJzerman AP, Jacobson KA, Klotz KN, Linden J, Müller CE, Schwabe U, Stiles GL. Adenosine receptors in GtoPdb v.2021.2. IUPHAR/BPS Guide to Pharmacology CITE. 2021; 2021(2).

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