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Bombesin Receptor 3 Antibodies

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Agonist-induced Threonine370 phosphorylation of the Bombesin Receptor 3
pT370-BB3 (phospho-Bombesin Receptor 3 Antibody)
Threonine370 (T370) is major phosphorylation site of the Bombesin Receptor 3 (BB3). The pT370-BB3 antibody detects phosphorylation in response to agonists. T370 phosphorylation is likely to be involved in efficient ligand sequestration...
$ 350.00
NEW
Agonist-induced Threonine363/Threonine364 phosphorylation of the Bombesin Receptor 3
pT363/pT364-BB3 (phospho-Bombesin Receptor 3...
Threonine363/Threonine360 (T363/T364) is major phosphorylation site of the Bombesin Receptor 3 (BB3). The pT363/pT364-BB3 antibody detects phosphorylation in response to agonists. T363/T364 phosphorylation is likely to be involved in...
$ 350.00
NEW
Agonist-induced Threonine360/Serine361 phosphorylation of the Bombesin Receptor 3
pT360/pS361-BB3 (phospho-Bombesin Receptor 3...
Threonine360/Serine361 (T360/S361) is major phosphorylation site of the Bombesin Receptor 3 (BB3). The pT360/pS361-BB3 antibody detects phosphorylation in response to agonists. T360/S361 phosphorylation is likely to be involved in...
$ 350.00

BB3

The natural ligand for the BB3 receptor remains unknown. Nevertheless it has been found that the synthetic bombesin analogs can bind and activate BB3 receptors. Recently a number of BB3 receptor nonpeptide agonists have been described including derivatives of omeprazole. Because the natural ligand of the BB3 receptor is not known most of the information on the possible physiological or pathophysiological role of this receptor has come from BB3 receptor knockout studies. BB3 receptor knockout mice develop mild obesity, associated with hypertension and impairment of glucose metabolism. These changes were associated with increased feeding behaviour, reduced metabolic rate, increased serum leptin and hyperphagia. These results suggested the BB3 receptor could play a role in energy balance, weight control and control of blood glucose levels. BB3 receptor desensitization, β-arrestin recruitment and internalization are regulated by phosphorylation of carboxyl-terminal threonine360/serine361 (pT360/pS361-BB3),  threonine363/threonine364 (pT363/pT364-BB3) and threonine370 (pT370-BB3). This nomenclature refers to the human BB3 receptor. For more information on BB3 pharmacology please refer to the IUPHAR database. For further reading refer to:

Jensen RT, Battey JF, Spindel ER, Benya RV. International Union of Pharmacology. LXVIII. Mammalian bombesin receptors: nomenclature, distribution, pharmacology, signaling, and functions in normal and disease states. Pharmacol Rev. 2008 Mar;60(1):1-42. doi: 10.1124/pr.107.07108. Epub 2007 Nov 30. PMID: 18055507; PMCID: PMC2517428.

The natural ligand for the BB3 receptor remains unknown. Nevertheless it has been found that the synthetic bombesin analogs can bind and activate BB3 receptors. Recently a number of BB3... read more »
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Bombesin Receptor 3 Antibodies

BB3

The natural ligand for the BB3 receptor remains unknown. Nevertheless it has been found that the synthetic bombesin analogs can bind and activate BB3 receptors. Recently a number of BB3 receptor nonpeptide agonists have been described including derivatives of omeprazole. Because the natural ligand of the BB3 receptor is not known most of the information on the possible physiological or pathophysiological role of this receptor has come from BB3 receptor knockout studies. BB3 receptor knockout mice develop mild obesity, associated with hypertension and impairment of glucose metabolism. These changes were associated with increased feeding behaviour, reduced metabolic rate, increased serum leptin and hyperphagia. These results suggested the BB3 receptor could play a role in energy balance, weight control and control of blood glucose levels. BB3 receptor desensitization, β-arrestin recruitment and internalization are regulated by phosphorylation of carboxyl-terminal threonine360/serine361 (pT360/pS361-BB3),  threonine363/threonine364 (pT363/pT364-BB3) and threonine370 (pT370-BB3). This nomenclature refers to the human BB3 receptor. For more information on BB3 pharmacology please refer to the IUPHAR database. For further reading refer to:

Jensen RT, Battey JF, Spindel ER, Benya RV. International Union of Pharmacology. LXVIII. Mammalian bombesin receptors: nomenclature, distribution, pharmacology, signaling, and functions in normal and disease states. Pharmacol Rev. 2008 Mar;60(1):1-42. doi: 10.1124/pr.107.07108. Epub 2007 Nov 30. PMID: 18055507; PMCID: PMC2517428.

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