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CXC Chemokine Receptor 2 Antibodies

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Agonist-induced Threonine347 phosphorylation of the CXC Chemokine Receptor 2
pT347-CXCR2 (phospho-CXC Chemokine Receptor 2...
Threonine347 (T347) is a major phosphorylation site of the CXCR2 receptor. The pT347-CXCR2 antibody detects phosphorylation in response to high- and low-efficacy agonists but not after PKC activation. T347 phosphorylation is a key...
$ 375.00 *
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Agonist-induced Serine351/Serine352 phosphorylation of the CXC Chemokine Receptor 2
pS351/pS352-CXCR2 (phospho-CXC Chemokine...
Serine351/Serine352 (S351/S352) is a major phosphorylation site of the CXCR2 receptor. The pS351/pS352-CXCR2 antibody detects phosphorylation in response to high- and low-efficacy agonists but not after PKC activation. S351/S352...
$ 375.00 *
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NEW
Agonist-induced Serine353/Threonine356 phosphorylation of the CXC Chemokine Receptor 2
pS353/pT356-CXCR2 (phospho-CXC Chemokine...
Serine353/Threonine356 (S353/T356) is a major phosphorylation site of the CXCR2 receptor. The pS353/pT356-CXCR2 antibody detects phosphorylation in response to high- and low-efficacy agonists but not after PKC activation. S353/T356...
$ 375.00 *
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Validation of the CXCR2 Receptor in transfected HEK293 cells
CXCR2 (non-phospho), CXCR2 Chemokine Receptor...
The non-phospho-CXCR2 receptor antibody is directed against the distal end of the carboxyl-terminal tail of human CXCR2. It can be used to detect total CXCR2 receptors in Western blots independent of phosphorylation.
$ 375.00 *
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C-X-C chemokine receptor 2 (CXCR2), encoded by CXCR2, is a class A G protein-coupled receptor activated by the endogenous ELR-positive chemokines CXCL1, CXCL2, CXCL3, CXCL5, CXCL6, CXCL7, and CXCL8. It couples predominantly to Gi/o and activates pathways that regulate calcium mobilization, cell adhesion, and chemotaxis. CXCR2 is highly expressed on neutrophils and has also been detected in vascular endothelial cells and subsets of tumor cells. It helps control neutrophil release from the bone marrow and directs their recruitment to sites of infection or tissue injury. Excessive CXCR2-dependent neutrophil recruitment can contribute to tissue damage in inflammatory diseases, including chronic airway disorders. Agonist stimulation can induce receptor phosphorylation and β-arrestin recruitment, promoting desensitization and internalization. Internalized receptors can recycle to the cell surface, restoring responsiveness to chemokines. Small-molecule antagonists such as danirixin and navarixin have been evaluated in clinical trials for inflammatory airway diseases. No CXCR2-selective antagonist is currently approved for therapeutic use. CXCR2 receptor desensitization, β-arrestin recruitment and internalization are regulated by phosphorylation of carboxyl-terminal threonine347 (pT347-CXCR2), serine351/serine352 (pS351/pS352-CXCR2) and serine353/threonine355 (pS353/pT356-CXCR2). This nomenclature refers to the human CXCR2 but is highly conserved in mice and rats. For more information on CXCR2 pharmacology please refer to the IUPHAR database. For further reading refer to:

Bachelerie F, Ben-Baruch A, Burkhardt AM, Combadiere C, Farber JM, Graham GJ, Horuk R, Sparre-Ulrich AH, Locati M, Luster AD, Mantovani A, Matsushima K, Murphy PM, Nibbs R, Nomiyama H, Power CA, Proudfoot AE, Rosenkilde MM, Rot A, Sozzani S, Thelen M, Yoshie O, Zlotnik A. International Union of Basic and Clinical Pharmacology. LXXXIX. Update on the extended family of chemokine receptors and introducing a new nomenclature for atypical chemokine receptors. Pharmacol Rev. 2013 Nov 11;66(1):1-79. doi: 10.1124/pr.113.007724. Print 2014. Review. Erratum in: Pharmacol Rev. 2014 Apr;66(2):467. PubMed PMID: 24218476; PubMed Central PMCID: PMC3880466.

C-X-C chemokine receptor 2 (CXCR2), encoded by CXCR2 , is a class A G protein-coupled receptor activated by the endogenous ELR-positive chemokines CXCL1, CXCL2, CXCL3, CXCL5, CXCL6, CXCL7,... read more »
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CXC Chemokine Receptor 2 Antibodies

C-X-C chemokine receptor 2 (CXCR2), encoded by CXCR2, is a class A G protein-coupled receptor activated by the endogenous ELR-positive chemokines CXCL1, CXCL2, CXCL3, CXCL5, CXCL6, CXCL7, and CXCL8. It couples predominantly to Gi/o and activates pathways that regulate calcium mobilization, cell adhesion, and chemotaxis. CXCR2 is highly expressed on neutrophils and has also been detected in vascular endothelial cells and subsets of tumor cells. It helps control neutrophil release from the bone marrow and directs their recruitment to sites of infection or tissue injury. Excessive CXCR2-dependent neutrophil recruitment can contribute to tissue damage in inflammatory diseases, including chronic airway disorders. Agonist stimulation can induce receptor phosphorylation and β-arrestin recruitment, promoting desensitization and internalization. Internalized receptors can recycle to the cell surface, restoring responsiveness to chemokines. Small-molecule antagonists such as danirixin and navarixin have been evaluated in clinical trials for inflammatory airway diseases. No CXCR2-selective antagonist is currently approved for therapeutic use. CXCR2 receptor desensitization, β-arrestin recruitment and internalization are regulated by phosphorylation of carboxyl-terminal threonine347 (pT347-CXCR2), serine351/serine352 (pS351/pS352-CXCR2) and serine353/threonine355 (pS353/pT356-CXCR2). This nomenclature refers to the human CXCR2 but is highly conserved in mice and rats. For more information on CXCR2 pharmacology please refer to the IUPHAR database. For further reading refer to:

Bachelerie F, Ben-Baruch A, Burkhardt AM, Combadiere C, Farber JM, Graham GJ, Horuk R, Sparre-Ulrich AH, Locati M, Luster AD, Mantovani A, Matsushima K, Murphy PM, Nibbs R, Nomiyama H, Power CA, Proudfoot AE, Rosenkilde MM, Rot A, Sozzani S, Thelen M, Yoshie O, Zlotnik A. International Union of Basic and Clinical Pharmacology. LXXXIX. Update on the extended family of chemokine receptors and introducing a new nomenclature for atypical chemokine receptors. Pharmacol Rev. 2013 Nov 11;66(1):1-79. doi: 10.1124/pr.113.007724. Print 2014. Review. Erratum in: Pharmacol Rev. 2014 Apr;66(2):467. PubMed PMID: 24218476; PubMed Central PMCID: PMC3880466.

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