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β1-Adrenoceptor Antibodies

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Agonist-induced Threonine371 phosphorylation of the TRH1-Receptor
pT371-TRH1 (phospho-Thyrotropin-Releasing...
Threonine371 (T371) is a major phosphorylation site of the TRH1 receptor. The pT371-TRH1 antibody detects phosphorylation in response to high- and low-efficacy agonists but not after PKC activation. T371 phosphorylation is primarily...
$ 350.00
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Agonist-induced Serine364/Threonine365 phosphorylation of the TRH1-Receptor
pS364/pT365-TRH1 (phospho-Thyrotropin-Releasing...
Serine364/Threonine365 (S364/T365) is a major phosphorylation site of the TRH1 receptor. The pS364/pT365-TRH1 antibody detects phosphorylation in response to high- and low-efficacy agonists but not after PKC activation. S364/T365...
$ 350.00
NEW
Agonist-induced Serine360 phosphorylation of the TRH1-Receptor
pS360-TRH1 (phospho-Thyrotropin-Releasing...
Serine360 (S360) is a major phosphorylation site of the TRH1 receptor. The pS360-TRH1 antibody detects phosphorylation in response to high- and low-efficacy agonists but not after PKC activation. S360 phosphorylation is primarily...
$ 350.00
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Validation of the β1-Adrenoceptor in transfected HEK293 cells
β1 (non-phospho), β1-Adrenoceptor Antibody
The non-phospho- β1 antibody is directed against the carboxyl-terminal tail of human β1 . It can be used to detect total β1 receptors in Western blots independent of phosphorylation. The non-phospho- β1 antibody can also be used to...
$ 350.00
NEW
Agonist-induced Threonine404 phosphorylation of the β1-Adrenoceptor
pT404-β1 (phospho-β1-Adrenoceptor Antibody)
Threonine404 (T404) is a major phosphorylation site of the β1 adrenoceptor. The pT404-β1 antibody detects phosphorylation in response to high- and low-efficacy agonists but not after PKC activation. T404 phosphorylation is primarily...
$ 350.00
NEW
Agonist-induced Serine412 phosphorylation of the β1-Adrenoceptor
pS412-β1 (phospho-β1-Adrenoceptor Antibody)
Serine412 (S412) is a major phosphorylation site of the β1 adrenoceptor. The pS412-β1 antibody detects phosphorylation in response to high- and low-efficacy agonists but not after PKC activation. S412 phosphorylation is primarily...
$ 350.00

The β1-adrenoceptor is the dominant receptor in heart and adipose tissue. The β1-adrenoceptor is equally sensitive to noradrenaline and adrenaline. Highly selective β1-antagonists have been developed that have proved useful in the treatment of a variety of diseases, including hypertension, angina pectoris and congestive heart failure.β1-adrenoceptors are regulated by phosphorylation of carboxyl-terminal threonine404 (pT404-ß1) and serine412 (pS412-ß1). This nomenclature refers to the human ß1. In mouse and rat β1-adrenoceptors only serine412 (pS412-ß1) is present. For more information on β1-adrenoceptor pharmacology please refer to the IUPHAR database. For further reading refer to:

Altosaar K, Balaji P, Bond RA, Bylund DB, Cotecchia S, Devost D, Doze VA, Eikenburg DC, Gora S, Goupil E, Graham RM, Hébert T, Hieble JP, Hills R, Kan S, Machkalyan G, Michel MC, Minneman KP, Parra S, Perez D, Sleno R, Summers R, Zylbergold P. Adrenoceptors (version 2019.3) in the IUPHAR/BPS Guide to Pharmacology Database. IUPHAR/BPS Guide to Pharmacology CITE. 2019; 2019(3). Available from: https://doi.org/10.2218/gtopdb/F4/2021.3.

Kobilka BK. Structural insights into adrenergic receptor function and pharmacology. Trends Pharmacol Sci. 2011 Apr;32(4):213-8. doi: 10.1016/j.tips.2011.02.005. Epub 2011 Mar 15. PMID: 21414670; PMCID: PMC3090711.

The β1-adrenoceptor is the dominant receptor in heart and adipose tissue. The β1-adrenoceptor is equally sensitive to noradrenaline and adrenaline. Highly selective β1-antagonists have been... read more »
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β1-Adrenoceptor Antibodies

The β1-adrenoceptor is the dominant receptor in heart and adipose tissue. The β1-adrenoceptor is equally sensitive to noradrenaline and adrenaline. Highly selective β1-antagonists have been developed that have proved useful in the treatment of a variety of diseases, including hypertension, angina pectoris and congestive heart failure.β1-adrenoceptors are regulated by phosphorylation of carboxyl-terminal threonine404 (pT404-ß1) and serine412 (pS412-ß1). This nomenclature refers to the human ß1. In mouse and rat β1-adrenoceptors only serine412 (pS412-ß1) is present. For more information on β1-adrenoceptor pharmacology please refer to the IUPHAR database. For further reading refer to:

Altosaar K, Balaji P, Bond RA, Bylund DB, Cotecchia S, Devost D, Doze VA, Eikenburg DC, Gora S, Goupil E, Graham RM, Hébert T, Hieble JP, Hills R, Kan S, Machkalyan G, Michel MC, Minneman KP, Parra S, Perez D, Sleno R, Summers R, Zylbergold P. Adrenoceptors (version 2019.3) in the IUPHAR/BPS Guide to Pharmacology Database. IUPHAR/BPS Guide to Pharmacology CITE. 2019; 2019(3). Available from: https://doi.org/10.2218/gtopdb/F4/2021.3.

Kobilka BK. Structural insights into adrenergic receptor function and pharmacology. Trends Pharmacol Sci. 2011 Apr;32(4):213-8. doi: 10.1016/j.tips.2011.02.005. Epub 2011 Mar 15. PMID: 21414670; PMCID: PMC3090711.

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