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EP4 Receptor Antibodies

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Agonist-induced Serine374/Serine377 phosphorylation of the EP4 Prostanoid Receptor
pS374/pS377-EP4 (phospho-EP4 Prostanoid...
Serine374/Serine377 (S374/S377) is major phosphorylation site of the EP4 Prostanoid Receptor (EP4). The pS374/pS377-EP4 antibody detects phosphorylation in response to agonists. S374/S377 phosphorylation is likely to be involved in...
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Agonist-induce Serine364/Serine366 phosphorylation of the EP4 Prostanoid Receptor
pS364/pS366-EP4 (phospho-EP4 Prostanoid...
Serine364/Serine366 (S364/S366) is major phosphorylation site of the EP4 Prostanoid Receptor (EP4). The pS364/pS366-EP4 antibody detects phosphorylation in response to agonists. S364/S366 phosphorylation is likely to be involved in...
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pT369/pS370-EP4 (phospho-EP4 Prostanoid Receptor Antibody)
pT369/pS370-EP4 (phospho-EP4 Prostanoid...
Threonine369/Serine370 (T369/S370) is major phosphorylation site of the EP4 Prostanoid Receptor (EP4). The pT369/pS370-EP4 antibody detects phosphorylation in response to agonists. T369/S370 phosphorylation is likely to be involved in...
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EP4 receptors preferentially couple through Gs protein to stimulate adenylate cyclase. The functional selectivity of natural and synthetic EP4 receptor agonists has been assessed in terms of cAMP production and β-arrestin recruitment. Currently there is interest in selective EP4 receptor antagonists as anti-inflammatory agents.EP4 receptors are regulated by phosphorylation of carboxyl-terminal serine364/serine366 (pS364/pS366-EP4), threonine369/serine370 (pT369/pS370-EP4) and serine374/serine377 (pS374/pS377-EP4). This nomenclature refers to the human EP4 receptor. This phosphorylation motif is conserved across species but corresponds to pS392/pS394-EP4, pT397/pS398-EP4 and pS402/pS405-EP4 in mice and pS367/pS369-EP4, pT371/pS372-EP4 and pS377/pS380-EP4 in rats. For more information on prostanoid receptor pharmacology please refer to the IUPHAR database. For further reading refer to:

Coleman RA, Smith WL, Narumiya S. International Union of Pharmacology classification of prostanoid receptors: properties, distribution, and structure of the receptors and their subtypes. Pharmacol Rev. 1994 Jun;46(2):205-29. PMID: 7938166.

Woodward DF, Jones RL, Narumiya S. International Union of Basic and Clinical Pharmacology. LXXXIII: classification of prostanoid receptors, updating 15 years of progress. Pharmacol Rev. 2011 Sep;63(3):471-538. doi: 10.1124/pr.110.003517. PMID: 21752876.

EP4 receptors preferentially couple through Gs protein to stimulate adenylate cyclase. The functional selectivity of natural and synthetic EP4 receptor agonists has been assessed in terms of... read more »
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EP4 Receptor Antibodies

EP4 receptors preferentially couple through Gs protein to stimulate adenylate cyclase. The functional selectivity of natural and synthetic EP4 receptor agonists has been assessed in terms of cAMP production and β-arrestin recruitment. Currently there is interest in selective EP4 receptor antagonists as anti-inflammatory agents.EP4 receptors are regulated by phosphorylation of carboxyl-terminal serine364/serine366 (pS364/pS366-EP4), threonine369/serine370 (pT369/pS370-EP4) and serine374/serine377 (pS374/pS377-EP4). This nomenclature refers to the human EP4 receptor. This phosphorylation motif is conserved across species but corresponds to pS392/pS394-EP4, pT397/pS398-EP4 and pS402/pS405-EP4 in mice and pS367/pS369-EP4, pT371/pS372-EP4 and pS377/pS380-EP4 in rats. For more information on prostanoid receptor pharmacology please refer to the IUPHAR database. For further reading refer to:

Coleman RA, Smith WL, Narumiya S. International Union of Pharmacology classification of prostanoid receptors: properties, distribution, and structure of the receptors and their subtypes. Pharmacol Rev. 1994 Jun;46(2):205-29. PMID: 7938166.

Woodward DF, Jones RL, Narumiya S. International Union of Basic and Clinical Pharmacology. LXXXIII: classification of prostanoid receptors, updating 15 years of progress. Pharmacol Rev. 2011 Sep;63(3):471-538. doi: 10.1124/pr.110.003517. PMID: 21752876.

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