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D1 Dopamine Receptor Antibodies

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OD signals in pT354-D1 Phosphorylation Assay
pT354-D1 Phosphorylation Assay Kit
The pT354-D1 Phosphorylation Assay Kit allows determination of D1 Phosphorylation in 96-well plates without the need for Western blot analysis.
$ 300.00 $ 600.00 *
50
NEW
OD signals in pS372/pS373-D1 Phosphorylation Assay
pS372/pS373-D1 Phosphorylation Assay Kit
The pS372/pS373-D1 Phosphorylation Assay Kit allows determination of D1 Phosphorylation in 96-well plates without the need for Western blot analysis.
$ 300.00 $ 600.00 *

 

 

D1aHGRSWzWKW1E1

The dopamine D1 receptor belongs to the D1-like subfamily of dopamine receptors. It stimulates cAMP production by coupling to stimulatory G proteins. The classical view of dopamine receptor signaling implies that the D1 receptor stimulates the cAMP/PKA/DARPP-32 pathway. Moreover, D1 receptor-mediated PKA activation also results in the activation of the extracellular signal-regulated kinases 1/2 (Erk1/2) by two mechanisms: src-Shp2-dependent Erk1/2 phosphorylation and DARPP-32-mediated inhibition of protein phosphatase-1. It is believed that upregulation of these mechanisms, leading to aberrant Erk1/2 activation, are involved in the development of L-DOPA-induced dyskinesias in animal models of Parkinson’s disease. D1 desensitization, trafficking and signaling are regulated by phosphorylation of carboxyl-terminal threonine354 (pT354-D1), serine372/serine373 (pS372/pS373-D1). This nomenclature refers to the human D1. This phosphorylation motif is also present in mice and rats. For more information on D1 receptor pharmacology please refer to the IUPHAR database. For further reading refer to:

Undieh AS. Pharmacology of signaling induced by dopamine D(1)-like receptor activation. Pharmacol Ther. 2010 Oct;128(1):37-60. doi: 10.1016/j.pharmthera.2010.05.003. Epub 2010 Jun 12. PMID: 20547182; PMCID: PMC2939266.

Beaulieu JM, Gainetdinov RR. The physiology, signaling, and pharmacology of dopamine receptors. Pharmacol Rev. 2011 Mar;63(1):182-217. doi: 10.1124/pr.110.002642. Epub 2011 Feb 8. PMID: 21303898.

Beaulieu JM, Espinoza S, Gainetdinov RR. Dopamine receptors - IUPHAR Review 13. Br J Pharmacol. 2015 Jan;172(1):1-23. doi: 10.1111/bph.12906. PMID: 25671228; PMCID: PMC4280963.

    The dopamine D1 receptor belongs to the D1-like subfamily of dopamine receptors. It stimulates cAMP production by coupling to stimulatory G proteins. The classical view of... read more »
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D1 Dopamine Receptor Antibodies

 

 

D1aHGRSWzWKW1E1

The dopamine D1 receptor belongs to the D1-like subfamily of dopamine receptors. It stimulates cAMP production by coupling to stimulatory G proteins. The classical view of dopamine receptor signaling implies that the D1 receptor stimulates the cAMP/PKA/DARPP-32 pathway. Moreover, D1 receptor-mediated PKA activation also results in the activation of the extracellular signal-regulated kinases 1/2 (Erk1/2) by two mechanisms: src-Shp2-dependent Erk1/2 phosphorylation and DARPP-32-mediated inhibition of protein phosphatase-1. It is believed that upregulation of these mechanisms, leading to aberrant Erk1/2 activation, are involved in the development of L-DOPA-induced dyskinesias in animal models of Parkinson’s disease. D1 desensitization, trafficking and signaling are regulated by phosphorylation of carboxyl-terminal threonine354 (pT354-D1), serine372/serine373 (pS372/pS373-D1). This nomenclature refers to the human D1. This phosphorylation motif is also present in mice and rats. For more information on D1 receptor pharmacology please refer to the IUPHAR database. For further reading refer to:

Undieh AS. Pharmacology of signaling induced by dopamine D(1)-like receptor activation. Pharmacol Ther. 2010 Oct;128(1):37-60. doi: 10.1016/j.pharmthera.2010.05.003. Epub 2010 Jun 12. PMID: 20547182; PMCID: PMC2939266.

Beaulieu JM, Gainetdinov RR. The physiology, signaling, and pharmacology of dopamine receptors. Pharmacol Rev. 2011 Mar;63(1):182-217. doi: 10.1124/pr.110.002642. Epub 2011 Feb 8. PMID: 21303898.

Beaulieu JM, Espinoza S, Gainetdinov RR. Dopamine receptors - IUPHAR Review 13. Br J Pharmacol. 2015 Jan;172(1):1-23. doi: 10.1111/bph.12906. PMID: 25671228; PMCID: PMC4280963.

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