Premium Phosphosite-Specific 7TM Antibodies
Novel Tools for Your GPCR Research
Select Your Country of Delivery below

Sphingosine 1-Phosphate Receptor Phosphorylation Assays

Sphingosine 1-phosphate (S1P) receptors are activated by the endogenous lipid sphingosine 1-phosphate. The receptors are designated as S1P1 through S1P5 receptors. S1P receptors, particularly S1P1, are expressed throughout all mammalian organ systems. Ligand delivery occurs via two known carriers: albumin and HDL-bound apolipoprotein M. Fingolimod (FTY720) binds as a phosphorylated metabolite to four of the five S1P receptors, and was the first oral therapy for multiple sclerosis (MS). Second-generation S1PR modulators siponimod, ozanimod, and ponesimod that target S1P1 and S1P5 are also FDA approved for the treatment of various MS forms. In 2021, ozanimod became the first S1P receptor modulator to be FDA approved for the treatment of ulcerative colitis. The mechanisms of action of fingolimod and other S1P receptor-modulating drugs now in development include binding S1P receptors in multiple organ systems, e.g., immune and nervous systems, although the precise nature of their receptor interactions requires further clarification.

Close filters
No results were found for the filter!
NEW
pS345-S1P5 Phosphorylation Assay Kit
pS345-S1P5 Phosphorylation Assay Kit
The pS345-S1P5 Phosphorylation Assay Kit allows determination of S1P5 Phosphorylation in 96-well plates without the need for Western blot analysis.
$ 600.00 *
NEW
pS351/pS353-S1P1 Phosphorylation Assay Kit
pS351/pS353-S1P1 Phosphorylation Assay Kit
The pS351/pS353-S1P1 Phosphorylation Assay Kit allows determination of S1P1 Phosphorylation in 96-well plates without the need for Western blot analysis.
$ 600.00 *
NEW
pS358/pS359-S1P1 Phosphorylation Assay Kit
pS358/pS359-S1P1 Phosphorylation Assay Kit
The pS358/pS359-S1P1 Phosphorylation Assay Kit allows determination of S1P1 Phosphorylation in 96-well plates without the need for Western blot analysis.
$ 600.00 *

For more information on somatostatin receptor pharmacology please refer to IUPHAR database. For further reading refer to:

Chun J, Hla T, Lynch KR, Spiegel S, Moolenaar WH. International Union of Basic and Clinical Pharmacology. LXXVIII. Lysophospholipid receptor nomenclature. Pharmacol Rev. 2010 Dec;62(4):579-87. doi: 10.1124/pr.110.003111. PMID: 21079037; PMCID: PMC2993255.

Kihara Y, Maceyka M, Spiegel S, Chun J. Lysophospholipid receptor nomenclature review: IUPHAR Review 8. Br J Pharmacol. 2014 Aug;171(15):3575-94. doi: 10.1111/bph.12678. Epub 2014 Jul 12. PMID: 24602016; PMCID: PMC4128058.

Blaho V, Chun J, Herr D, Jones D, Jonnalagadda D, Kihara Y. Lysophospholipid (S1P) receptors in GtoPdb v.2023.1. IUPHAR/BPS Guide to Pharmacology CITE. 2023; 2023(1).

For more information on somatostatin receptor pharmacology please refer to IUPHAR database. For further reading refer to: Chun J, Hla T, Lynch KR, Spiegel S, Moolenaar WH. International Union... read more »
Close window
Sphingosine 1-Phosphate Receptor Phosphorylation Assays

For more information on somatostatin receptor pharmacology please refer to IUPHAR database. For further reading refer to:

Chun J, Hla T, Lynch KR, Spiegel S, Moolenaar WH. International Union of Basic and Clinical Pharmacology. LXXVIII. Lysophospholipid receptor nomenclature. Pharmacol Rev. 2010 Dec;62(4):579-87. doi: 10.1124/pr.110.003111. PMID: 21079037; PMCID: PMC2993255.

Kihara Y, Maceyka M, Spiegel S, Chun J. Lysophospholipid receptor nomenclature review: IUPHAR Review 8. Br J Pharmacol. 2014 Aug;171(15):3575-94. doi: 10.1111/bph.12678. Epub 2014 Jul 12. PMID: 24602016; PMCID: PMC4128058.

Blaho V, Chun J, Herr D, Jones D, Jonnalagadda D, Kihara Y. Lysophospholipid (S1P) receptors in GtoPdb v.2023.1. IUPHAR/BPS Guide to Pharmacology CITE. 2023; 2023(1).

Recently viewed