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Orphan Receptor Antibodies

The sequencing of the human genome has allowed NC-IUPHAR to catalog all of the human gene sequences potentially encoding GPCRs, excluding sensory receptors. In addition to established transmitter systems, the classification in the Guide to PHARMACOLOGY also includes ‘orphan’ GPCRs where the endogenous ligand(s) is not known. Considerable progress has been made in screening artificially expressed receptors to identify the cognate endogenous ligand.

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Agonist-induced Serine343 phosphorylation of GPR183
pS343-GPR183 (phospho-GPR183 Antibody)
Serine343 (S343) is major phosphorylation site of human GPR183 receptor. The pS343-GPR183 antibody detects phosphorylation in response to agonists. S343 phosphorylation is likely to be involved in efficient ligand sequestration by GPR183.
$ 350.00 *
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Agonist-induced Threoine347/Serine349 phosphorylation of GPR183
pT347/pT349-GPR183 (phospho-GPR183 Antibody)
Threonine347/threonine349 (T347/T349) is major phosphorylation site of human GPR183 receptor. The pT347/pT349-GPR183 antibody detects phosphorylation in response to agonists. T347/T349 phosphorylation is likely to be involved in...
$ 350.00 *
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Agonist-induced Serine355 phosphorylation of GPR183
pS355-GPR183 (phospho-GPR183 Antibody)
Serine355 (S355) is major phosphorylation site of human GPR183 receptor. The pS355-GPR183 antibody detects phosphorylation in response to agonists. S355 phosphorylation is likely to be involved in efficient ligand sequestration by GPR183.
$ 350.00 *
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Agonist-induced Threoine339/Serine341 phosphorylation of GPR132
pT339/pS341-GPR132 (phospho-GPR132 Antibody)
Threonine339/Serine341 (T339/S341) is major phosphorylation site of human GPR132 receptor. The pT339/pS341-GPR132 antibody detects phosphorylation in response to agonists. T339/S341 phosphorylation is likely to be involved in efficient...
$ 350.00 *
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Agonist-induced Threonine344/Serine349 phosphorylation of GPR132
pT344/pS349-GPR132 (phospho-GPR132 Antibody)
Threonine344/Serine349 (T344/S349) is major phosphorylation site of human GPR132 receptor. The pT344/pS349-GPR132 antibody detects phosphorylation in response to agonists. T344/S349 phosphorylation is likely to be involved in efficient...
$ 350.00 *
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Agonist-induced Threonine358/Serine360 phosphorylation of GPR132
pT358/pS360-GPR132 (phospho-GPR132 Antibody)
Threonine358/Serine360 (T358/S360) is major phosphorylation site of human GPR132 receptor. The pT358/pS360-GPR132 antibody detects phosphorylation in response to agonists. T358/S360 phosphorylation is likely to be involved in efficient...
$ 350.00 *
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Agonist-induced Serine327/Serine328 phosphorylation of the MRGPRX2 Mas-related Receptor
pS327/pS328-MRGPRX2 (phospho-MRGPRX2...
Serine327/Serine328 (S327/S329) is a major phosphorylation site of the MRGPRX2 Mas-related receptor. The pS327/pS328-MRGPRX2 antibody detects phosphorylation in response to high- and low-efficacy agonists and after PKC activation....
$ 350.00 *
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Agonist-induced Serine313 phosphorylation of the MRGPRX2 Mas-related Receptor
pS313-MRGPRX2 (phospho-MRGPRX2 Mas-related...
Serine313 (S313) is a major phosphorylation site of the MRGPRX2 Mas-related receptor. The pS313-MRGPRX2 antibody detects phosphorylation in response to high- and low-efficacy agonists and after PKC activation. S313 phosphorylation is a...
$ 350.00 *
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Agonist-induced Threonine263/Threonine264 phosphorylation of GPR84
pT263/pT264-GPR84 (phospho-GPR84 Antibody)
Threonine263/Threonine264 (T263/T264) is major phosphorylation site of human GPR84 receptor. The pT263/pT264-GPR84 antibody detects phosphorylation in response to agonists. T263/T264 phosphorylation is likely to be involved in efficient...
$ 350.00 *
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Agonist-induced Serine221/Serine224 phosphorylation of GPR84
pS221/pS224-GPR84 (phospho-GPR84 Antibody)
Serine221/Serine224 (S221/S224) is major phosphorylation site of human GPR84 receptor. The pS221/pS224-GPR84 antibody detects phosphorylation in response to agonists. S221/S224 phosphorylation is likely to be involved in efficient ligand...
$ 350.00 *
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pS351/pT356-GPR17 (phospho-GPR17 Antibody)
pS351/pT356-GPR17 (phospho-GPR17 Antibody)
Serine351/Threonine356 (S351/T356) is a major phosphorylation site of the human GPR17 receptor. The pS351/pT356-GPR17 antibody detects phosphorylation in response to high-efficacy agonists. S351/T356 phosphorylation is a key regulator of...
$ 350.00 *
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Validation of the G Protein-coupled Receptor 17 in transfected HEK293 cells
GPR17 (non-phospho), G Protein-coupled Receptor...
The non-phospho-GPR17 receptor antibody is directed against the distal part of the carboxyl-terminal tail of human GPR17. It can be used to detect total GPR17 receptors in Western blots independent of phosphorylation. The...
$ 350.00 *
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Detection of non-phosphorylated human GPR35 Receptor
GPR35 (non-phospho), G Protein-coupled Receptor...
The non-phospho-GPR35 receptor antibody is directed against the distal part of the carboxyl-terminal tail of human GPR35. It can be used to detect total GPR35 receptors in Western blots independent of phosphorylation. The...
$ 350.00 *
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Agonist-induced Serine298/Serine301 phosphorylation of mouse GPR35 Receptor
pS298/pS301-mGPR35 (phospho-mouse GPR35 Antibody)
Serine298/Serine301 (S298/S301) is a major phosphorylation site of the mouse GPR35 receptor. The pS298/pS301-mGPR35 antibody detects phosphorylation in response to high-efficacy agonists. S298/S301 phosphorylation is a key regulator of...
$ 350.00 *
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Agonist-induced Serine300/Serine303 phosphorylation of GPR35 Receptor
pS300/pS303-hGPR35 (phospho-human GPR35 Antibody)
Serine300/Serine303 (S300/S303) is a major phosphorylation site of the human GPR35 receptor. The pS300/pS303-hGPR35 antibody detects phosphorylation in response to high-efficacy agonists. S300/S303 phosphorylation is a key regulator of...
$ 350.00 *
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Validation of the G protein-coupled Receptor 84 in transfected HEK293 cells
GPR84 (non-phospho), G Protein-Coupled Receptor...
The GPR84 antibody is directed against the distal end of the carboxyl-terminal tail of human GRP84. It can be used to detect total GPR84 receptors in Western blots independent of phosphorylation. The GPR84 antibody can also be used to...
$ 350.00 *
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For more information on orphan receptor pharmacology please refer to the IUPHAR database. For further reading refer to:

Davenport AP, Alexander SP, Sharman JL, Pawson AJ, Benson HE, Monaghan AE, Liew WC, Mpamhanga CP, Bonner TI, Neubig RR, Pin JP, Spedding M, Harmar AJ. International Union of Basic and Clinical Pharmacology. LXXXVIII. G protein-coupled receptor list: recommendations for new pairings with cognate ligands. Pharmacol Rev. 2013 May 17;65(3):967-86. doi: 10.1124/pr.112.007179. PMID: 23686350; PMCID: PMC3698937.

For more information on orphan receptor pharmacology please refer to the  IUPHAR  database. For further reading refer to: Davenport AP, Alexander SP, Sharman JL, Pawson AJ, Benson HE,... read more »
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Orphan Receptor Antibodies

For more information on orphan receptor pharmacology please refer to the IUPHAR database. For further reading refer to:

Davenport AP, Alexander SP, Sharman JL, Pawson AJ, Benson HE, Monaghan AE, Liew WC, Mpamhanga CP, Bonner TI, Neubig RR, Pin JP, Spedding M, Harmar AJ. International Union of Basic and Clinical Pharmacology. LXXXVIII. G protein-coupled receptor list: recommendations for new pairings with cognate ligands. Pharmacol Rev. 2013 May 17;65(3):967-86. doi: 10.1124/pr.112.007179. PMID: 23686350; PMCID: PMC3698937.

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