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GPR84 Receptor Antibodies

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Immunohistochemical identification of G Protein-coupled Receptor 84 in lymph node
GPR84 (IHC-grade), G Protein-Coupled Receptor...
The GPR84 antibody is directed against the distal end of the carboxyl-terminal tail of human GRP84. It can be used to detect total GPR84 receptors in Western blots independent of phosphorylation. The GPR84 antibody can also be used to...
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Agonist-induced Serine221/Serine224 phosphorylation of GPR84
pS221/pS224-GPR84 (phospho-GPR84 Antibody)
Serine221/Serine224 (S221/S224) is major phosphorylation site of human GPR84 receptor. The pS221/pS224-GPR84 antibody detects phosphorylation in response to agonists. S221/S224 phosphorylation is likely to be involved in efficient ligand...
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Agonist-induced Threonine263/Threonine264 phosphorylation of GPR84
pT263/pT264-GPR84 (phospho-GPR84 Antibody)
Threonine263/Threonine264 (T263/T264) is major phosphorylation site of human GPR84 receptor. The pT263/pT264-GPR84 antibody detects phosphorylation in response to agonists. T263/T264 phosphorylation is likely to be involved in efficient...
$ 375.00 *
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Validation of the G protein-coupled Receptor 84 in transfected HEK293 cells
GPR84 (non-phospho), G Protein-Coupled Receptor...
The GPR84 antibody is directed against the distal end of the carboxyl-terminal tail of human GRP84. It can be used to detect total GPR84 receptors in Western blots independent of phosphorylation. The GPR84 antibody can also be used to...
$ 375.00 *
Details

G protein-coupled receptor 84 (GPR84), encoded by GPR84, is a class A receptor that couples predominantly to Gi/o and inhibits adenylyl cyclase. Medium-chain fatty acids such as decanoic and undecanoic acid activate GPR84 in experimental systems, although their role as physiological agonists remains uncertain. GPR84 is expressed mainly in myeloid cells, including neutrophils, monocytes, macrophages, and microglia. Inflammatory stimuli such as bacterial lipopolysaccharide can markedly increase its expression in macrophages. In preclinical models, GPR84 activation can promote myeloid cell migration and amplify inflammatory responses. Agonists differ in their ability to recruit β-arrestins and induce receptor internalization, and the synthetic agonist 6-OAU is widely used to study these responses. The oral antagonist GLPG1205 was evaluated in phase 2 trials for ulcerative colitis and idiopathic pulmonary fibrosis, where it did not meet the primary efficacy endpoints. No GPR84-selective drug is currently approved for therapeutic use. GPR84 desensitization, β-arrestin recruitment and internalization are regulated by phosphorylation of 3rd intracellular loop threonine263/threonine264 (pT263/pT264-GPR84). This nomenclature refers to the human GPR84 receptor. For more information on GPR84 pharmacology please refer to the IUPHAR database. For further reading refer to:

Stoddart LA, Smith NJ, Milligan G. International Union of Pharmacology. LXXI. Free fatty acid receptors FFA1, -2, and -3: pharmacology and pathophysiological functions. Pharmacol Rev. 2008 Dec;60(4):405-17. doi: 10.1124/pr.108.00802. Epub 2008 Dec 1. PMID: 19047536.

Riddy DM, Delerive P, Summers RJ, Sexton PM, Langmead CJ. G Protein-Coupled Receptors Targeting Insulin Resistance, Obesity, and Type 2 Diabetes Mellitus. Pharmacol Rev. 2018 Jan;70(1):39-67. doi: 10.1124/pr.117.014373. PMID: 29233848.

Marsango S, Ward RJ, Jenkins L, Butcher AJ, Al Mahmud Z, Dwomoh L, Nagel F, Schulz S, Tikhonova IG, Tobin AB, Milligan G. Selective phosphorylation of threonine residues defines GPR84-arrestin interactions of biased ligands. J Biol Chem. 2022 May;298(5):101932. doi: 10.1016/j.jbc.2022.101932. Epub 2022 Apr 12. PMID: 35427647; PMCID: PMC9118924.

G protein-coupled receptor 84 (GPR84), encoded by GPR84 , is a class A receptor that couples predominantly to Gi/o and inhibits adenylyl cyclase. Medium-chain fatty acids such as decanoic and... read more »
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GPR84 Receptor Antibodies

G protein-coupled receptor 84 (GPR84), encoded by GPR84, is a class A receptor that couples predominantly to Gi/o and inhibits adenylyl cyclase. Medium-chain fatty acids such as decanoic and undecanoic acid activate GPR84 in experimental systems, although their role as physiological agonists remains uncertain. GPR84 is expressed mainly in myeloid cells, including neutrophils, monocytes, macrophages, and microglia. Inflammatory stimuli such as bacterial lipopolysaccharide can markedly increase its expression in macrophages. In preclinical models, GPR84 activation can promote myeloid cell migration and amplify inflammatory responses. Agonists differ in their ability to recruit β-arrestins and induce receptor internalization, and the synthetic agonist 6-OAU is widely used to study these responses. The oral antagonist GLPG1205 was evaluated in phase 2 trials for ulcerative colitis and idiopathic pulmonary fibrosis, where it did not meet the primary efficacy endpoints. No GPR84-selective drug is currently approved for therapeutic use. GPR84 desensitization, β-arrestin recruitment and internalization are regulated by phosphorylation of 3rd intracellular loop threonine263/threonine264 (pT263/pT264-GPR84). This nomenclature refers to the human GPR84 receptor. For more information on GPR84 pharmacology please refer to the IUPHAR database. For further reading refer to:

Stoddart LA, Smith NJ, Milligan G. International Union of Pharmacology. LXXI. Free fatty acid receptors FFA1, -2, and -3: pharmacology and pathophysiological functions. Pharmacol Rev. 2008 Dec;60(4):405-17. doi: 10.1124/pr.108.00802. Epub 2008 Dec 1. PMID: 19047536.

Riddy DM, Delerive P, Summers RJ, Sexton PM, Langmead CJ. G Protein-Coupled Receptors Targeting Insulin Resistance, Obesity, and Type 2 Diabetes Mellitus. Pharmacol Rev. 2018 Jan;70(1):39-67. doi: 10.1124/pr.117.014373. PMID: 29233848.

Marsango S, Ward RJ, Jenkins L, Butcher AJ, Al Mahmud Z, Dwomoh L, Nagel F, Schulz S, Tikhonova IG, Tobin AB, Milligan G. Selective phosphorylation of threonine residues defines GPR84-arrestin interactions of biased ligands. J Biol Chem. 2022 May;298(5):101932. doi: 10.1016/j.jbc.2022.101932. Epub 2022 Apr 12. PMID: 35427647; PMCID: PMC9118924.

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