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CC Chemokine Receptor 5 Antibodies

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Agonist-induced Serine342 phosphorylation of the Chemokine Receptor 5
pS342-CCR5 (phospho-Chemokine Receptor 5 Antibody)
Serine342 (S342) is a major phosphorylation site of the CCR5 receptor. The pS342-CCR5 antibody detects phosphorylation in response to high- and low-efficacy agonists and after PKC activation. S342 phosphorylation is a key regulator of...
$ 375.00 *
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NEW
Agonist-induced Serine336/Serine337 phosphorylation of the Chemokine Receptor 5
pS336/pS337-CCR5 (phospho-Chemokine Receptor 5...
Serine336/Serine337 (S336/S337) is a major phosphorylation site of the CCR5 receptor. The pS336/pS337-CCR5 antibody detects phosphorylation in response to high- and low-efficacy agonists and after PKC activation. S336/S337...
$ 375.00 *
Details
NEW
Agonist-induced Threonine340 phosphorylation of the Chemokine Receptor 5
pT340-CCR5 (phospho-Chemokine Receptor 5 Antibody)
Threonine340 (T340) is a major phosphorylation site of the CCR5 receptor. The pT340-CCR5 antibody detects phosphorylation in response to high- and low-efficacy agonists and after PKC activation. T340 phosphorylation is a key regulator of...
$ 375.00 *
Details

CCR5

The CC chemokine receptor 5 (CCR5) is a receptor for many chemokine including CCL4, CCL5, CCL8, CCL3, CCL2, CCL14, CCL11 and CCL16. CCR5 is also the most important co-receptor for HIV transmission and is the only one demonstrated to play an essential role in HIV/AIDS pathogenesis. The CCR5 receptor antagonist maraviroc has beeen approved as HIV entry blocker for all known CCR5-tropic HIV-1 strains. CCR5 desensitization, β-arrestin recruitment and internalization are regulated by phosphorylation of carboxyl-terminal serine336/serine337 (pS336/pS337-CCR5), threonine340 (pT340-CCR5) and serine342 (pS342-CCR5) residues. This nomenclature refers to the human CCR5. This phosphorylation motif is highly conserved across species and is also present in mice and rats. For more information on CCR5 pharmacology please refer to the IUPHAR database. For further reading refer to:

Isaikina P, Petrovic I, Jakob RP, Sarma P, Ranjan A, Baruah M, Panwalkar V, Maier T, Shukla AK, Grzesiek S. A key GPCR phosphorylation motif discovered in arrestin2⋅CCR5 phosphopeptide complexes. Mol Cell. 2023 Jun 15;83(12):2108-2121.e7. doi: 10.1016/j.molcel.2023.05.002. Epub 2023 May 26. PMID: 37244255.

Bachelerie F, Ben-Baruch A, Burkhardt AM, Combadiere C, Farber JM, Graham GJ, Horuk R, Sparre-Ulrich AH, Locati M, Luster AD, Mantovani A, Matsushima K, Murphy PM, Nibbs R, Nomiyama H, Power CA, Proudfoot AE, Rosenkilde MM, Rot A, Sozzani S, Thelen M, Yoshie O, Zlotnik A. International Union of Basic and Clinical Pharmacology. LXXXIX. Update on the extended family of chemokine receptors and introducing a new nomenclature for atypical chemokine receptors. Pharmacol Rev. 2013 Nov 11;66(1):1-79. doi: 10.1124/pr.113.007724. Print 2014. Review. Erratum in: Pharmacol Rev. 2014 Apr;66(2):467. PubMed PMID: 24218476; PubMed Central PMCID: PMC3880466.

The CC chemokine receptor 5 (CCR5) is a receptor for many chemokine including CCL4, CCL5, CCL8, CCL3, CCL2, CCL14, CCL11 and CCL16. CCR5 is also the most important co-receptor for HIV... read more »
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CC Chemokine Receptor 5 Antibodies

CCR5

The CC chemokine receptor 5 (CCR5) is a receptor for many chemokine including CCL4, CCL5, CCL8, CCL3, CCL2, CCL14, CCL11 and CCL16. CCR5 is also the most important co-receptor for HIV transmission and is the only one demonstrated to play an essential role in HIV/AIDS pathogenesis. The CCR5 receptor antagonist maraviroc has beeen approved as HIV entry blocker for all known CCR5-tropic HIV-1 strains. CCR5 desensitization, β-arrestin recruitment and internalization are regulated by phosphorylation of carboxyl-terminal serine336/serine337 (pS336/pS337-CCR5), threonine340 (pT340-CCR5) and serine342 (pS342-CCR5) residues. This nomenclature refers to the human CCR5. This phosphorylation motif is highly conserved across species and is also present in mice and rats. For more information on CCR5 pharmacology please refer to the IUPHAR database. For further reading refer to:

Isaikina P, Petrovic I, Jakob RP, Sarma P, Ranjan A, Baruah M, Panwalkar V, Maier T, Shukla AK, Grzesiek S. A key GPCR phosphorylation motif discovered in arrestin2⋅CCR5 phosphopeptide complexes. Mol Cell. 2023 Jun 15;83(12):2108-2121.e7. doi: 10.1016/j.molcel.2023.05.002. Epub 2023 May 26. PMID: 37244255.

Bachelerie F, Ben-Baruch A, Burkhardt AM, Combadiere C, Farber JM, Graham GJ, Horuk R, Sparre-Ulrich AH, Locati M, Luster AD, Mantovani A, Matsushima K, Murphy PM, Nibbs R, Nomiyama H, Power CA, Proudfoot AE, Rosenkilde MM, Rot A, Sozzani S, Thelen M, Yoshie O, Zlotnik A. International Union of Basic and Clinical Pharmacology. LXXXIX. Update on the extended family of chemokine receptors and introducing a new nomenclature for atypical chemokine receptors. Pharmacol Rev. 2013 Nov 11;66(1):1-79. doi: 10.1124/pr.113.007724. Print 2014. Review. Erratum in: Pharmacol Rev. 2014 Apr;66(2):467. PubMed PMID: 24218476; PubMed Central PMCID: PMC3880466.

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