CC Chemokine Receptor 5 Antibodies
The CC chemokine receptor 5 (CCR5) is a receptor for many chemokine including CCL4, CCL5, CCL8, CCL3, CCL2, CCL14, CCL11 and CCL16. CCR5 is also the most important co-receptor for HIV transmission and is the only one demonstrated to play an essential role in HIV/AIDS pathogenesis. The CCR5 receptor antagonist maraviroc has beeen approved as HIV entry blocker for all known CCR5-tropic HIV-1 strains. CCR5 desensitization, β-arrestin recruitment and internalization are regulated by phosphorylation of carboxyl-terminal serine336/serine337 (pS336/pS337-CCR5), threonine340 (pT340-CCR5) and serine342 (pS342-CCR5) residues. This nomenclature refers to the human CCR5. This phosphorylation motif is highly conserved across species and is also present in mice and rats. For more information on CCR5 pharmacology please refer to the IUPHAR database. For further reading refer to:
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