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Dopamine Receptor Phosphorylation Assays

Dopamine is the predominant catecholamine transmitter in the central nervous system that controls locomotor activity, motivation, positive reinforcement and hormonal regulation by interacting with a family of five G protein-coupled receptors (GPCRs) designated D1-D5. Based on structural and functional differences dopamine receptors were divided into the D1-like and D2-like subfamilies. D1-like receptors include D1 and D5, which stimulate cAMP production by coupling to stimulatory G proteins. The D2-like receptors include D2, D3 and D4, which inhibit cAMP production by coupling to inhibitory G proteins. The D2 receptor is a pharmacological target for drugs widely used to treat symptoms for disorders associated with dopaminergic dysfunctions, including Parkinson’s disease and schizophrenia.

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OD signals in pT354-D1 Phosphorylation Assay
pT354-D1 Phosphorylation Assay Kit
The pT354-D1 Phosphorylation Assay Kit allows determination of D1 Phosphorylation in 96-well plates without the need for Western blot analysis.
$ 600.00 *
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OD signals in pS372/pS373-D1 Phosphorylation Assay
pS372/pS373-D1 Phosphorylation Assay Kit
The pS372/pS373-D1 Phosphorylation Assay Kit allows determination of D1 Phosphorylation in 96-well plates without the need for Western blot analysis.
$ 600.00 *

For more information on dopamine receptor pharmacology please refer to the IUPHAR database. For further reading refer to:

Beaulieu JM, Gainetdinov RR. The physiology, signaling, and pharmacology of dopamine receptors. Pharmacol Rev. 2011 Mar;63(1):182-217. doi:10.1124/pr.110.002642. Epub 2011 Feb 8. Review. PubMed PMID: 21303898.

Beaulieu JM, Espinoza S, Gainetdinov RR. Dopamine receptors - IUPHAR Review 13. Br J Pharmacol. 2015 Jan;172(1):1-23. Review. PubMed PMID: 25671228; PubMed Central PMCID: PMC4280963.

For more information on dopamine receptor pharmacology please refer to the IUPHAR database. For further reading refer to: Beaulieu JM, Gainetdinov RR. The physiology, signaling, and... read more »
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Dopamine Receptor Phosphorylation Assays

For more information on dopamine receptor pharmacology please refer to the IUPHAR database. For further reading refer to:

Beaulieu JM, Gainetdinov RR. The physiology, signaling, and pharmacology of dopamine receptors. Pharmacol Rev. 2011 Mar;63(1):182-217. doi:10.1124/pr.110.002642. Epub 2011 Feb 8. Review. PubMed PMID: 21303898.

Beaulieu JM, Espinoza S, Gainetdinov RR. Dopamine receptors - IUPHAR Review 13. Br J Pharmacol. 2015 Jan;172(1):1-23. Review. PubMed PMID: 25671228; PubMed Central PMCID: PMC4280963.

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