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5-HT Receptor Antibodies

5-Hydroxytryptamine (5-HT) receptors are, with the exception of the ionotropic 5-HT3 class, GPCRs where the endogenous agonist is 5-hydroxytryptamine (serotonin). 5-HT receptors are distributed amongst seven distinct families, with some families containing multiple receptors, classified primarily on their similar amino acid sequences and structural properties. Further 5-HT receptor heterogeneity is generated through alternative splicing (5-HT3, 5-HT4 and 5-HT7 receptors), RNA editing (5-HT2C receptors) and the putative formation of heterodimers.

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Agonist-induced Serine354/Threonine355 phosphorylation of the 5-Hydroxytryptamine Receptor 4
pS354/pT355-5-HT4 (phospho-5-HT Receptor 4...
Serine354/Threonine355 is a major phosphorylation site of the 5-HT4 receptor. The pS354/pT355-5-HT4 antibody detects phosphorylation in response to high-efficacy agonists but not after PKC activation. S354/T355 phosphorylation is a key...
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NEW
Agonist-induced Threonine343/Serine347/Threonine348 phosphorylation of the 5-Hydroxytryptamine Receptor 4
pT343/pS347/pT348-5-HT4 (phospho-5-HT Receptor...
Threonine343/Serine347/Threonine348 is a major phosphorylation site of the 5-HT4 receptor. The pT343/pS347/pT348-5-HT4 antibody detects phosphorylation in response to high-efficacy agonists but not after PKC activation. T343/S347/T348...
$ 350.00
Details

For more information on 5-HT receptor pharmacology please refer to the IUPHAR database. For further reading refer to:

Barnes NM, Ahern GP, Becamel C, Bockaert J, Camilleri M, Chaumont-Dubel S, Claeysen S, Cunningham KA, Fone KC, Gershon M, Di Giovanni G, Goodfellow NM, Halberstadt AL, Hartley RM, Hassaine G, Herrick-Davis K, Hovius R, Lacivita E, Lambe EK, Leopoldo M, Levy FO, Lummis SCR, Marin P, Maroteaux L, McCreary AC, Nelson DL, Neumaier JF, Newman-Tancredi A, Nury H, Roberts A, Roth BL, Roumier A, Sanger GJ, Teitler M, Sharp T, Villalón CM, Vogel H, Watts SW, Hoyer D. International Union of Basic and Clinical Pharmacology. CX. Classification of Receptors for 5-hydroxytryptamine; Pharmacology and Function. Pharmacol Rev. 2021 Jan;73(1):310-520. doi: 10.1124/pr.118.015552. PMID: 33370241; PMCID: PMC7770494.

Hoyer D, Clarke DE, Fozard JR, Hartig PR, Martin GR, Mylecharane EJ, Saxena PR, Humphrey PP. International Union of Pharmacology classification of receptors for 5-hydroxytryptamine (Serotonin). Pharmacol Rev. 1994 Jun;46(2):157-203. PMID: 7938165.

Hartig PR, Hoyer D, Humphrey PP, Martin GR. Alignment of receptor nomenclature with the human genome: classification of 5-HT1B and 5-HT1D receptor subtypes. Trends Pharmacol Sci. 1996 Mar;17(3):103-5. doi: 10.1016/0165-6147(96)30002-3. PMID: 8936345.

Fink KB, Göthert M. 5-HT receptor regulation of neurotransmitter release. Pharmacol Rev. 2007 Dec;59(4):360-417. doi: 10.1124/pr.107.07103. Erratum in: Pharmacol Rev. 2008 Mar;60(1):142. PMID: 18160701.

Bockaert J, Claeysen S, Compan V, Dumuis A. 5-HT(4) receptors, a place in the sun: act two. Curr Opin Pharmacol. 2011 Feb;11(1):87-93. doi: 10.1016/j.coph.2011.01.012. Epub 2011 Feb 20. PMID: 21342787.

For more information on 5-HT receptor pharmacology please refer to the IUPHAR database. For further reading refer to: Barnes NM, Ahern GP, Becamel C, Bockaert J, Camilleri M, Chaumont-Dubel... read more »
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5-HT Receptor Antibodies

For more information on 5-HT receptor pharmacology please refer to the IUPHAR database. For further reading refer to:

Barnes NM, Ahern GP, Becamel C, Bockaert J, Camilleri M, Chaumont-Dubel S, Claeysen S, Cunningham KA, Fone KC, Gershon M, Di Giovanni G, Goodfellow NM, Halberstadt AL, Hartley RM, Hassaine G, Herrick-Davis K, Hovius R, Lacivita E, Lambe EK, Leopoldo M, Levy FO, Lummis SCR, Marin P, Maroteaux L, McCreary AC, Nelson DL, Neumaier JF, Newman-Tancredi A, Nury H, Roberts A, Roth BL, Roumier A, Sanger GJ, Teitler M, Sharp T, Villalón CM, Vogel H, Watts SW, Hoyer D. International Union of Basic and Clinical Pharmacology. CX. Classification of Receptors for 5-hydroxytryptamine; Pharmacology and Function. Pharmacol Rev. 2021 Jan;73(1):310-520. doi: 10.1124/pr.118.015552. PMID: 33370241; PMCID: PMC7770494.

Hoyer D, Clarke DE, Fozard JR, Hartig PR, Martin GR, Mylecharane EJ, Saxena PR, Humphrey PP. International Union of Pharmacology classification of receptors for 5-hydroxytryptamine (Serotonin). Pharmacol Rev. 1994 Jun;46(2):157-203. PMID: 7938165.

Hartig PR, Hoyer D, Humphrey PP, Martin GR. Alignment of receptor nomenclature with the human genome: classification of 5-HT1B and 5-HT1D receptor subtypes. Trends Pharmacol Sci. 1996 Mar;17(3):103-5. doi: 10.1016/0165-6147(96)30002-3. PMID: 8936345.

Fink KB, Göthert M. 5-HT receptor regulation of neurotransmitter release. Pharmacol Rev. 2007 Dec;59(4):360-417. doi: 10.1124/pr.107.07103. Erratum in: Pharmacol Rev. 2008 Mar;60(1):142. PMID: 18160701.

Bockaert J, Claeysen S, Compan V, Dumuis A. 5-HT(4) receptors, a place in the sun: act two. Curr Opin Pharmacol. 2011 Feb;11(1):87-93. doi: 10.1016/j.coph.2011.01.012. Epub 2011 Feb 20. PMID: 21342787.

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