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VPAC1 Receptor Antibodies

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Agonist-induced Serine422/Serine425 phosphorylation of VPAC1 Receptor
pS422/pS425-VPAC1 (phospho-VIP Receptor 1...
Serine422/Serine425 (S422/S425) is a major phosphorylation site of the VPAC1 receptor. The pS422/pS425-VPAC1 antibody detects phosphorylation in response to high-efficacy agonists. S422/S425 phosphorylation is a key regulator of VPAC1...
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Agonist-induced Threonine429/Serine431/Threonine432 phosphorylation of VPAC1 Receptor
pT429/pS431/pT432-VPAC1 (phospho-VIP Receptor 1...
Threonine429/Serine431/Threonine432 (T429/S431/T432) is a major phosphorylation site of the VPAC1 receptor. The pT429/pS431/pT432-VPAC1 antibody detects phosphorylation in response to high-efficacy agonists. T429/S431/T432...
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Agonist-induced and Agonist-independent Serine435/Threonine438 phosphorylation of VAPC1 Receptor
pS435/pT438-VPAC1 (phospho-VIP Receptor 1...
Serine435/Threonine438 (S435/T438) is a major phosphorylation site of the VPAC1 receptor. The pS435/pT438-VPAC1 antibody detects phosphorylation in response to high-efficacy agonists. S422/S425 phosphorylation is a key regulator of VPAC1...
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Validation of the VIP receptor 1 in transfected HEK293 cells
VPAC1 (non-phospho), VIP Receptor 1 Antibody
The VPAC1 antibody is directed against the distal end of the carboxyl-terminal tail of human VIP Receptor 1. It can be used to detect total VPAC1 receptors in Western blots independent of phosphorylation. The VPAC1 antibody can also be...
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The VPAC1 receptor, which responds to VIP and PACAP with comparable affinity. This receptor is widely distributed in the CNS, most abundantly in the cerebral cortex and hippocampus, in peripheral tissues including liver, lung and intestine and in T lymphocytes. Selective VPAC1 receptor agonists and antagonists have been reported. VPAC1 receptor desensitization, β-arrestin recruitment and internalization are regulated by phosphorylation of carboxyl-terminal serine422/serine425 (pS422/pS425-VPAC1), threonine429/serine431/threonine432 (pT429/pS431/pT432-VPAC1) and serine435/serine438 (pS435/pT438-VPAC1). This nomenclature refers to the human VPAC1 receptor. This phosphorylation motif is highly conserved across species but corresponds to pS427-VPAC1, pT431/pS433/pT434-VPAC1 and pS437/pT440-VPAC1 in mice and rats. For more information on VPAC1 pharmacology please refer to the IUPHAR database. For further reading refer to:

Harmar AJ, Fahrenkrug J, Gozes I, Laburthe M, May V, Pisegna JR, Vaudry D, Vaudry H, Waschek JA, Said SI. Pharmacology and functions of receptors for vasoactive intestinal peptide and pituitary adenylate cyclase-activating polypeptide: IUPHAR review 1. Br J Pharmacol. 2012 May;166(1):4-17. doi: 10.1111/j.1476-5381.2012.01871.x. PMID: 22289055; PMCID: PMC3415633.

Laburthe M, Couvineau A, Marie JC. VPAC receptors for VIP and PACAP. Recept Channels. 2002;8(3-4):137-53. PMID: 12529932.

Fahrenkrug J, Goetzl EJ, Gozes I, Harmar A, Laburthe M, May V, Pisegna JR, Said SI, Vaudry H, Vaudry D, Waschek JA. VIP and PACAP receptors (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database. IUPHAR/BPS Guide to Pharmacology CITE. 2019; 2019(4).

The VPAC1 receptor, which responds to VIP and PACAP with comparable affinity. This receptor is widely distributed in the CNS, most abundantly in the cerebral cortex and hippocampus, in... read more »
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VPAC1 Receptor Antibodies

The VPAC1 receptor, which responds to VIP and PACAP with comparable affinity. This receptor is widely distributed in the CNS, most abundantly in the cerebral cortex and hippocampus, in peripheral tissues including liver, lung and intestine and in T lymphocytes. Selective VPAC1 receptor agonists and antagonists have been reported. VPAC1 receptor desensitization, β-arrestin recruitment and internalization are regulated by phosphorylation of carboxyl-terminal serine422/serine425 (pS422/pS425-VPAC1), threonine429/serine431/threonine432 (pT429/pS431/pT432-VPAC1) and serine435/serine438 (pS435/pT438-VPAC1). This nomenclature refers to the human VPAC1 receptor. This phosphorylation motif is highly conserved across species but corresponds to pS427-VPAC1, pT431/pS433/pT434-VPAC1 and pS437/pT440-VPAC1 in mice and rats. For more information on VPAC1 pharmacology please refer to the IUPHAR database. For further reading refer to:

Harmar AJ, Fahrenkrug J, Gozes I, Laburthe M, May V, Pisegna JR, Vaudry D, Vaudry H, Waschek JA, Said SI. Pharmacology and functions of receptors for vasoactive intestinal peptide and pituitary adenylate cyclase-activating polypeptide: IUPHAR review 1. Br J Pharmacol. 2012 May;166(1):4-17. doi: 10.1111/j.1476-5381.2012.01871.x. PMID: 22289055; PMCID: PMC3415633.

Laburthe M, Couvineau A, Marie JC. VPAC receptors for VIP and PACAP. Recept Channels. 2002;8(3-4):137-53. PMID: 12529932.

Fahrenkrug J, Goetzl EJ, Gozes I, Harmar A, Laburthe M, May V, Pisegna JR, Said SI, Vaudry H, Vaudry D, Waschek JA. VIP and PACAP receptors (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database. IUPHAR/BPS Guide to Pharmacology CITE. 2019; 2019(4).

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