Immuno-Grade Dopamine Receptor 1 Antibodies
The dopamine D1 receptor belongs to the D1-like subfamily of dopamine receptors. It stimulates cAMP production by coupling to stimulatory G proteins. The classical view of dopamine receptor signaling implies that the D1 receptor stimulates the cAMP/PKA/DARPP-32 pathway. Moreover, D1 receptor-mediated PKA activation also results in the activation of the extracellular signal-regulated kinases 1/2 (Erk1/2) by two mechanisms: src-Shp2-dependent Erk1/2 phosphorylation and DARPP-32-mediated inhibition of protein phosphatase-1. It is believed that upregulation of these mechanisms, leading to aberrant Erk1/2 activation, are involved in the development of L-DOPA-induced dyskinesias in animal models of Parkinson’s disease.