Galanin Receptor Antibodies

Galanin receptors are activated by the endogenous peptides galanin (GAL) and galanin-like peptide (GALP).The three galanin receptors, GAL1, GAL2 and GAL3, share a number of characteristics as members of the 7TM/GPCR family, but their functional coupling and signal transduction pathways are substantially different. GAL1 is widely expressed in the CNS with high expression in olfactory structures, amygdala, thalamus, hypothalamus, pons, medulla and spinal cord. GAL2 is abundant in the spinal trigeminal tract and the dorsal vagal complex. GAL3 is abundant in peripheral tissues. Galanin and galanin receptors have been linked to the regulation of a range of functions including metabolic and osmotic homeostasis, reproduction, nociception, arousal/sleep and cognition.