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Endothelin Receptor Antibodies

In mammals, the endothelin (ET) family comprises three endogenous isoforms, ET-1, ET-2 and ET-3, and the receptors that mediate their effects have been classified as the endothelin ETA and ETB receptors. Endothelin is able to activate a number of signal transduction processes including phospholipase PLA2, PLC and PLD. ETA receptors expressed in CHO cells couple to Gq and Gs. ETB receptors couple to Gq and Gi. Endothelin receptors are widely expressed, consistent with the physiological role of endothelins as ubiquitous endothelium-derived vasoactive peptides, contributing to the maintenance of vascular tone. Receptors are also localised to non-vascular structures such as epithelial cells as well as occurring in the central nervous system (CNS). In human vessels, ETA receptors are mainly located on vascular smooth muscle cells, with ETB receptors being present on endothelial cells lining the vessel wall. ETB receptors may play a role in the release of endothelium-derived relaxing factors such as nitric oxide (NO) and prostanoids from endothelial cells. ETA receptors present on smooth muscle cells are mainly responsible for contraction. A selective ETA receptor agonist has not been discovered to date. Sarafotoxin S6c is a selective ETB receptor agonist. Antagonists that block both ETA and ETB receptors include the peptide TAK044 and the non-peptide compounds bosentan and SB209670.

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Agonist-induced Serine435/Serine436 phosphorylation of the Endothelin Receptor B
pS435/pS436-ETB (phospho-Endothelin Receptor B...
Serine435/Serine436 (S435/S436) is major phosphorylation site of the Endothelin Receptor B (ETB). The pS435/pS436-ETB antibody detects phosphorylation in response to agonists. S435/S436 phosphorylation is likely to be involved in...
$ 350.00
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Validation of the Endothelin Receptor B in transfected HEK293 cells.
ETB (non-phospho-Endothelin Receptor B Antibody)
The non-phospho-ETB receptor antibody is directed against the distal part of the carboxyl-terminal tail of human Endothelin Receptor B (ETB). It can be used to detect total ETB receptors in Western blots independent of phosphorylation....
$ 250.00

For more information on endothelin receptor pharmacology please refer to the IUPHAR database. For further reading refer to:

Barton M, Yanagisawa M. Endothelin: 30 Years From Discovery to Therapy. Hypertension. 2019 Dec;74(6):1232-1265. doi: 10.1161/HYPERTENSIONAHA.119.12105.Epub 2019 Nov 4. PMID: 31679425.

Davenport AP, Hyndman KA, Dhaun N, Southan C, Kohan DE, Pollock JS, Pollock DM, Webb DJ, Maguire JJ. Endothelin. Pharmacol Rev. 2016 Apr;68(2):357-418. doi: 10.1124/pr.115.011833. PMID: 26956245; PMCID: PMC4815360.

Davenport AP, D'Orléans-Juste P, Godfraind T, Maguire JJ, Ohlstein EH, Ruffolo RR. Endothelin receptors (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database. IUPHAR/BPS Guide to Pharmacology CITE. 2019; 2019(4).

For more information on endothelin receptor pharmacology please refer to the  IUPHAR  database. For further reading refer to: Barton M, Yanagisawa M. Endothelin: 30 Years From... read more »
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Endothelin Receptor Antibodies

For more information on endothelin receptor pharmacology please refer to the IUPHAR database. For further reading refer to:

Barton M, Yanagisawa M. Endothelin: 30 Years From Discovery to Therapy. Hypertension. 2019 Dec;74(6):1232-1265. doi: 10.1161/HYPERTENSIONAHA.119.12105.Epub 2019 Nov 4. PMID: 31679425.

Davenport AP, Hyndman KA, Dhaun N, Southan C, Kohan DE, Pollock JS, Pollock DM, Webb DJ, Maguire JJ. Endothelin. Pharmacol Rev. 2016 Apr;68(2):357-418. doi: 10.1124/pr.115.011833. PMID: 26956245; PMCID: PMC4815360.

Davenport AP, D'Orléans-Juste P, Godfraind T, Maguire JJ, Ohlstein EH, Ruffolo RR. Endothelin receptors (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database. IUPHAR/BPS Guide to Pharmacology CITE. 2019; 2019(4).

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