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D5 Dopamine Receptor Antibodies

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Agonist-induced Threonine382/Threonine386 phosphorylation of the Dopamine Receptor 5
pT382/pT386-D5 (phospho-Dopamine Receptor 5...
Threonine382/Threonine386 (T382/T386) is a major phosphorylation site of the D5 receptor. The pT382/pT386-D5 antibody detects phosphorylation in response to high- and low-efficacy agonists but not after PKC activation. T382/T386...
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D5

The dopamine D5 receptor belongs to the D1-like subfamily of dopamine receptors. It stimulates cAMP production by coupling to stimulatory G proteins. The classical view of dopamine receptor signaling implies that the D5 receptor stimulates the cAMP/PKA/DARPP-32 pathway. D5 desensitization, trafficking and signaling are regulated by phosphorylation of carboxyl-terminal threonine382/threonine386 (pT382/pT386-D5). This nomenclature refers to the human D5. For more information on D5 receptor pharmacology please refer to the IUPHAR database. For further reading refer to:

Undieh AS. Pharmacology of signaling induced by dopamine D(1)-like receptor activation. Pharmacol Ther. 2010 Oct;128(1):37-60. doi: 10.1016/j.pharmthera.2010.05.003. Epub 2010 Jun 12. PMID: 20547182; PMCID: PMC2939266.

Beaulieu JM, Gainetdinov RR. The physiology, signaling, and pharmacology of dopamine receptors. Pharmacol Rev. 2011 Mar;63(1):182-217. doi: 10.1124/pr.110.002642. Epub 2011 Feb 8. PMID: 21303898.

Beaulieu JM, Espinoza S, Gainetdinov RR. Dopamine receptors - IUPHAR Review 13. Br J Pharmacol. 2015 Jan;172(1):1-23. doi: 10.1111/bph.12906. PMID: 25671228; PMCID: PMC4280963.

The dopamine D5 receptor belongs to the D1-like subfamily of dopamine receptors. It stimulates cAMP production by coupling to stimulatory G proteins. The classical view of dopamine receptor... read more »
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D5 Dopamine Receptor Antibodies

D5

The dopamine D5 receptor belongs to the D1-like subfamily of dopamine receptors. It stimulates cAMP production by coupling to stimulatory G proteins. The classical view of dopamine receptor signaling implies that the D5 receptor stimulates the cAMP/PKA/DARPP-32 pathway. D5 desensitization, trafficking and signaling are regulated by phosphorylation of carboxyl-terminal threonine382/threonine386 (pT382/pT386-D5). This nomenclature refers to the human D5. For more information on D5 receptor pharmacology please refer to the IUPHAR database. For further reading refer to:

Undieh AS. Pharmacology of signaling induced by dopamine D(1)-like receptor activation. Pharmacol Ther. 2010 Oct;128(1):37-60. doi: 10.1016/j.pharmthera.2010.05.003. Epub 2010 Jun 12. PMID: 20547182; PMCID: PMC2939266.

Beaulieu JM, Gainetdinov RR. The physiology, signaling, and pharmacology of dopamine receptors. Pharmacol Rev. 2011 Mar;63(1):182-217. doi: 10.1124/pr.110.002642. Epub 2011 Feb 8. PMID: 21303898.

Beaulieu JM, Espinoza S, Gainetdinov RR. Dopamine receptors - IUPHAR Review 13. Br J Pharmacol. 2015 Jan;172(1):1-23. doi: 10.1111/bph.12906. PMID: 25671228; PMCID: PMC4280963.

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