P2Y12 Receptor Antibodies

P2Y12 is a receptor for ADP and primarily coupled to Gi/o proteins. P2Y12 is highly expressed in platelets where it plays a role in amplification of platelet activation and aggregation. The active metabolite of clopidogrel acts as potent P2Y12 antagonist and is an efficient antithrombotic drug. P2Y12 is regulated by by phosphorylation of carboxyl-terminal serine323 (pS323-P2Y12). This nomenclature refers to the human P2Y12. For more information on P2Y12 pharmacology please refer to the IUPHAR database. For further reading refer to:
Abbracchio MP, Burnstock G, Boeynaems JM, Barnard EA, Boyer JL, Kennedy C, Knight GE, Fumagalli M, Gachet C, Jacobson KA, Weisman GA. International Union of Pharmacology LVIII: update on the P2Y G protein-coupled nucleotide receptors: from molecular mechanisms and pathophysiology to therapy. Pharmacol Rev. 2006 Sep;58(3):281-341. doi: 10.1124/pr.58.3.3. PMID: 16968944; PMCID: PMC3471216.
Jacobson KA, Delicado EG, Gachet C, Kennedy C, von Kügelgen I, Li B, Miras-Portugal MT, Novak I, Schöneberg T, Perez-Sen R, Thor D, Wu B, Yang Z, Müller CE. Update of P2Y receptor pharmacology: IUPHAR Review 27. Br J Pharmacol. 2020 Jun;177(11):2413-2433. doi: 10.1111/bph.15005. Epub 2020 Apr 6. PMID: 32037507; PMCID: PMC7205808.
Jacobson KA, Paoletta S, Katritch V, Wu B, Gao ZG, Zhao Q, Stevens RC, Kiselev E. Nucleotides Acting at P2Y Receptors: Connecting Structure and Function. Mol Pharmacol. 2015 Aug;88(2):220-30. doi: 10.1124/mol.114.095711. Epub 2015 Apr 2. PMID: 25837834; PMCID: PMC4518082.