pT334/pS335-FPR3 (phospho-Formylpeptide Receptor 3 Antibody)

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Agonist-induced Threonine334/Serine335 phosphorylation of FPR3 Receptor

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Order number: 7TM0224A
Content: 100 µl
Host: Rabbit

Threonine334/Serine335 (T334/S335) is a major phosphorylation site of the FPR3 receptor.... more

Threonine334/Serine335 (T334/S335) is a major phosphorylation site of the FPR3 receptor. The pT334/pS335-FPR3 antibody detects phosphorylation in response to high-efficacy agonists. T334/S335 phosphorylation is a key regulator of FPR3 desensitization, β-arrestin recruitment and internalization.

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Alternative Names FPRL2, FPRH1, Formyl-peptide Receptor-like 2,... more

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Alternative Names	FPRL2, FPRH1, Formyl-peptide Receptor-like 2, Formyl-peptide Receptor 3
IUPHAR Target ID	224
UniProt ID	P25089
Western Blot (WB)	1:1000
Immunocytochemistry (ICC)	-
Species Reactivity	Human
Host / Isotype	Rabbit / IgG
Class	Polyclonal
Immunogen	A synthetic phosphopeptide derived from human FPR3 around the phosphorylation site Thr334/Ser335.
Form	Liquid
Purification	Antigen affinity chromatography
Storage buffer	Dulbecco's PBS, pH 7.4, with 150 mM NaCl, 0.02% sodium azide
Storage conditions	short-term 4°C, long-term -20°C

Figure 1. Agonist-induced Threonine334/Serine335 phosphorylation of FPR3 Receptor. Upper... more

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Figure 1. Agonist-induced Threonine334/Serine335 phosphorylation of FPR3 Receptor. Upper panel, HEK293 cells stably expressing the FPR3-Receptor (FPR3) were either not exposed or exposed to 1 µM of specific FPR-Receptor agonist WKYMVm for 30 minutes. Cells were lysed and immunoblotted with the anti-pT334/pS335-FPR3 antibody (7TM0224A) at a dilution of 1:1000. Lower panel, blot was stripped and reprobed with the phosphorylation-independent anti-FPR3 antibody (7TM0224N) at a dilution of 1:1000 to confirm equal loading of the gel.

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