pT362/pS363-NPY1 (phospho-Neuropeptide Y Receptor 1 Antibody)

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Agonist-induced Threonine362/Serine363 phosphorylation of the Neuropeptide Y receptor 1

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Order number: 7TM0305B
Content: 100 µl
Host: Rabbit

Threonine362/Serine363 (T362/S363) is a major phosphorylation site of the Neuropeptide Y... more

Threonine362/Serine363 (T362/S363) is a major phosphorylation site of the Neuropeptide Y Receptor 1. The pT362/pS363-NPY1 antibody detects phosphorylation in response to high- and low-efficacy agonists but not after PKC activation. T362/S363 phosphorylation is primarily mediated by GRKs and is a key regulator of NPY1 desensitization, β-arrestin recruitment and internalization.

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Alternative Names Y1, NPY 1 receptor, neuropeptide Y receptor type 1... more

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Alternative Names	Y1, NPY 1 receptor, neuropeptide Y receptor type 1
IUPHAR Target ID	305
UniProt ID	P25929
Western Blot (WB)	1:1000
Immunocytochemistry (ICC)	-
Species Reactivity	Human
Host / Isotype	Rabbit / IgG
Class	Polyclonal
Immunogen	A synthetic phosphopeptide derived from human NPY1 around the phosphorylation site of Thr362/Ser363.
Form	Liquid
Purification	Antigen affinity chromatography
Storage buffer	Dulbecco's PBS, pH 7.4, with 150 mM NaCl, 0.02% sodium azide
Storage conditions	short-term 4°C, long-term -20°C

Figure 1. Agonist-induced Threonine362/Serine363 phosphorylation of the Neuropeptide Y receptor... more

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Figure 1. Agonist-induced Threonine362/Serine363 phosphorylation of the Neuropeptide Y receptor 1. Upper panel, HEK293 cells stably expressing the NPY1-Receptor (NPY1) were either not exposed or exposed to 1 µM of NPY1 receptor agonist Neuropeptide Y for 30 minutes. Cells were lysed and immunoblotted with the anti-pT362/pS363-NPY1 antibody (7TM0305B) at a dilution of 1:1000. Lower panel, blot was stripped and reprobed with an phosphorylation-independent anti-NPY1 antibody to confirm equal loading of the gel.

Be the first to decipher the NPY1 phosphorylation barcode and let us know. more

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Be the first to decipher the NPY1 phosphorylation barcode and let us know.

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