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pS323-P2Y12 (phospho-P2Y Purinoceptor 12 Antibody)

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Agonist-induced Serine323 phosphorylation of the P2Y Receptor 12.
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  • 7TM0328A
  • 100 µl
  • Rabbit
Serine323 (S323) is a major phosphorylation site of the P2Y12 receptor. The pS323-P2Y12... more

Serine323 (S323) is a major phosphorylation site of the P2Y12 receptor. The pS323-P2Y12 antibody detects phosphorylation in response to high- and low-efficacy agonists and after PKC activation. S323 phosphorylation is a key regulator of P2Y12 desensitization, β-arrestin recruitment and internalization.

  Alternative Names P2Y12, P2Y Purinoceptor 12, Purinergic Receptor P2Y12... more

 

Alternative Names P2Y12, P2Y Purinoceptor 12, Purinergic Receptor P2Y12
IUPHAR Target ID  328
UniProt ID  Q9H244
Western Blot (WB)  1:1000
Immunocytochemistry (ICC)  -
Species Reactivity   Human
Host / Isotype Rabbit / IgG
Class Polyclonal
Immunogen A synthetic phosphopeptide derived from human P2Y12 around the phosphorylation site of Ser323.
Form  Liquid
Purification Antigen affinity chromatography
Storage buffer Dulbecco's PBS, pH 7.4, with 150 mM NaCl, 0.02% sodium azide
Storage conditions short-term 4°C, long-term -20°C
Figure 1. Agonist-induced Serine323 phosphorylation of the P2Y Purinoceptor 12. Upper panel,... more

Figure 1. Agonist-induced Serine323 phosphorylation of the P2Y Purinoceptor 12. Upper panel, HEK293 cells stably expressing the P2Y Purinoceptor 12 (P2Y12) were either not exposed or exposed to 1 µM ATP (Adenosintriphosphate) for 30 minutes. Cells were lysed and immunoblotted with the anti-pS323-P2Y12 antibody (7TM00328A) at a dilution of 1:1000. Lower panel, blot was stripped and reprobed with an phosphorylation-independent anti-P2Y12 antibody to confirm equal loading of the gel.


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