pS350/pS352-5-HT6 (phospho-5-HT Receptor 6 Antibody)

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Agonist-induced Serine350/Serine352 phosphorylation of the 5-Hydroxytryptamine Receptor 6

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Order number: 7TM0011A
Content: 100 µl
Host: Rabbit

Serine350/Serine352 is a major phosphorylation site of the 5-HT Receptor 6 (5-HT6).... more

Serine350/Serine352 is a major phosphorylation site of the 5-HT Receptor 6 (5-HT6). The pS350/pS352-5-HT6 antibody detects phosphorylation in response to high-efficacy agonists but not after PKC activation. S350/S352 phosphorylation is a key regulator of 5-HT6 desensitization, β-arrestin recruitment and internalization.

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Alternative Names 5-HT6, 5-Hydroxytryptamine Receptor 6, Serotonin Receptor... more

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Alternative Names	5-HT6, 5-Hydroxytryptamine Receptor 6, Serotonin Receptor 6
IUPHAR Target ID	11
UniProt ID	P50406
Western Blot (WB)	1:1000
Immunocytochemistry (ICC)	-
Species Reactivity	Human
Host / Isotype	Rabbit / IgG
Class	Polyclonal
Immunogen	A synthetic phosphopeptide derived from human 5-HT6 around the phosphorylation site of Ser350/Ser352.
Form	Liquid
Purification	Antigen affinity chromatography
Storage buffer	Dulbecco's PBS, pH 7.4, with 150 mM NaCl, 0.02% sodium azide
Storage conditions	short-term 4°C, long-term -20°C

Figure 1. Agonist-induced Serine350/Serine352 phosphorylation of the 5-Hydroxytryptamine... more

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Figure 1. Agonist-induced Serine350/Serine352 phosphorylation of the 5-Hydroxytryptamine Receptor 6. Upper panel, HEK293 cells stably expressing the 5-Hydroxytryptamine Receptor 6 (5-HT6) were either not exposed or exposed to 100 µM serotonin for 30 minutes. Cells were lysed and immunoblotted with the anti-pS350/pS352-5-HT6 antibody (7TM0011A) at a dilution of 1:1000. Lower panel, blot was stripped and reprobed with an phosphorylation-independent anti-5-HT6 antibody to confirm equal loading of the gel.

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