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pS345/pT346-NK2 (phospho-Tachykinin Receptor 2 Antibody)

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Agonist-induced Serine345/Threonine346 phosphorylation of NK2 Receptor.
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  • 7TM0361B
  • 100 µl
  • Rabbit
Serine345/Threonine346 (S345/T346) is a major phosphorylation site of the NK2 receptor.... more

Serine345/Threonine346 (S345/T346) is a major phosphorylation site of the NK2 receptor. The pS345/pT346-NK2 antibody detects phosphorylation in response to high-efficacy agonists. S345/T346 phosphorylation is a key regulator of NK2 desensitization, β-arrestin recruitment and internalization.

  Alternative Names NK2, SKR, TACR2, Neurokinin B Receptor, Substance K... more

 

Alternative Names NK2, SKR, TACR2, Neurokinin B Receptor, Substance K Receptor
IUPHAR Target ID  361
UniProt ID  P21452
Western Blot (WB)  1:1000
Immunocytochemistry (ICC)  -
Species Reactivity   Human
Host / Isotype Rabbit / IgG
Class Polyclonal
Immunogen A synthetic phosphopeptide derived from human NK2 around the phosphorylation site Ser345/Thr346.
Form  Liquid
Purification Antigen affinity chromatography
Storage buffer Dulbecco's PBS, pH 7.4, with 150 mM NaCl, 0.02% sodium azide
Storage conditions short-term 4°C, long-term -20°C
Figure 1. Agonist-induced Serine345/Threonine346 phosphorylation of NK2 Receptor. Upper... more

Figure 1. Agonist-induced Serine345/Threonine346 phosphorylation of NK2 Receptor. Upper panel, HEK293 cells stably expressing the NK2-Receptor (NK2) were either not exposed or exposed to 1 µM of specific NK2-Receptor agonist Neurokinin B for 30 minutes. Cells were lysed and immunoblotted with the anti-pS345/pT346-NK2 antibody (7TM0361B) at a dilution of 1:1000. Lower panel, blot was stripped and reprobed with an phosphorylation-independent anti-NK2 antibody to confirm equal loading of the gel.

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