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pT344/pS347-NK1 (phospho-Tachykinin Receptor 1 Antibody)

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pT344/pS347-NK1 (phospho-Tachykinin Receptor 1 Antibody)
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  • 7TM0360A
  • 100 µl
  • Rabbit
Threonine344/Serine347 (T344/S347) is a major phosphorylation site of the NK1 receptor.... more

Threonine344/Serine347 (T344/S347) is a major phosphorylation site of the NK1 receptor. The pT344/pS347-NK1 antibody detects phosphorylation in response to high-efficacy agonists. T344/S347 phosphorylation is a key regulator of NK1 desensitization, β-arrestin recruitment and internalization.

  Alternative Names NK1, SPR, TACR1, Neurokinin Receptor 1, Substance P... more

 

Alternative Names NK1, SPR, TACR1, Neurokinin Receptor 1, Substance P Receptor
IUPHAR Target ID  360
UniProt ID  P25103
Western Blot (WB)  1:1000
Immunocytochemistry (ICC)  -
Species Reactivity   Human
Host / Isotype Rabbit / IgG
Class Polyclonal
Immunogen A synthetic phosphopeptide derived from human NK1 around the phosphorylation site Thr344/Ser347.
Form  Liquid
Purification Antigen affinity chromatography
Storage buffer Dulbecco's PBS, pH 7.4, with 150 mM NaCl, 0.02% sodium azide
Storage conditions short-term 4°C, long-term -20°C
Figure 1. Agonist-induced Threonine344/Serine347 phosphorylation of NK1 Receptor. Upper... more

Figure 1. Agonist-induced Threonine344/Serine347 phosphorylation of NK1 Receptor. Upper panel, HEK293 cells stably expressing the NK1-Receptor (NK1) were either not exposed or exposed to 1 µM of specific NK1-Receptor agonist Substance P for 30 minutes. Cells were lysed and immunoblotted with the anti-pT344/pS347-NK1 antibody (7TM0360A) at a dilution of 1:1000. Lower panel, blot was stripped and reprobed with the phosphorylation-independent anti-NK1 antibody (7TM0360N) at a dilution of 1:1000 to confirm equal loading of the gel.

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